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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Natural sources of antineoplastic >Indirubin

Indirubin

Indirubin Structure
  • ₹10600
  • Product name: Indirubin
  • CAS: 479-41-4
  • MF: C16H10N2O2
  • MW: 262.26
  • EINECS:610-392-0
  • MDL Number:MFCD00221745
  • Synonyms:[2,3'-Biindolinylidene]-2',3-dione;Indirubin (Synthetic), >=98%;Indirubin/Folium Isatidis Extract;Nsc105327;INDIRUBIN (RG);(E)-3-(3-oxoindolin-2-ylidene)indolin-2-one;Isoindogotin;(delta(sup2,3’)-biindoline)-2’,3-dione
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Brand

  • TCI Chemicals (India)

Package

  • 25MG
  • ManufacturerTCI Chemicals (India)
  • Product numberI0868
  • Product descriptionIndirubin
  • Packaging25MG
  • Price₹10600
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) I0868 Indirubin 25MG ₹10600 2022-05-26 Buy

Properties

Melting point :350°C(lit.)
Boiling point :496.6±45.0 °C(Predicted)
Density :1.417±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO (Slightly), Methanol (Very Slightly, Heated)
pka :9.13±0.20(Predicted)
form :Purple powder.
color :Very Dark Red
λmax :540nm(DMSO)(lit.)
InChI :InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)
InChIKey :CRDNMYFJWFXOCH-UHFFFAOYSA-N
SMILES :N1C2=C(C=CC=C2)C(=C2C(=O)C3=C(N2)C=CC=C3)C1=O
CAS DataBase Reference :479-41-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

Indirubin is the active ingredient of Danggui Longhui Wan, a traditional Chinese medicine containing plants such as Indigofera tinctoria L. and Isatis tinctoria L, which are used in traditional Chinese medicine to treat chronic diseases. Indirubin and its analogues are reported as potent inhibitors of cyclin-dependent kinases (CDKs). This could attribute to the positive effect of indirubin on counteracting proliferative diseases, such as chronic myelocytic leukemia (CML), a slowly progressive disease characterized by the overproduction of granulocytes.

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