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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Natural sources of antineoplastic >Vinblastine sulfate

Vinblastine sulfate

Vinblastine sulfate Structure
  • ₹4135.15 - ₹70676.43
  • Product name: Vinblastine sulfate
  • CAS: 143-67-9
  • MF: C46H60N4O13S
  • MW: 909.05
  • EINECS:205-606-0
  • MDL Number:MFCD00082457
  • Synonyms:29060le ;nsc49842 ;rozevinsulfate ;velbe ;vincaleukoblastine,sulfate(1:1)(salt) ;Vinblastine, sulphate salt;VLB, Vincaleukoblastine sulphate salt;Vinblastine Sulphate USP
Price6 Properties Safety Information Description
6 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • 10MG
  • 25MG
  • 50MG
  • 100MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberV1377
  • Product descriptionVinblastine sulfate salt ≥97% (HPLC)
  • Packaging1MG
  • Price₹4135.15
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberV1377
  • Product descriptionVinblastine sulfate salt ≥97% (HPLC)
  • Packaging5MG
  • Price₹12784.33
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberV1377
  • Product descriptionVinblastine sulfate salt ≥97% (HPLC)
  • Packaging10MG
  • Price₹20740.7
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR2698
  • Product descriptionVinblastine Sulfate certified reference material, pharmaceutical secondary standard
  • Packaging100MG
  • Price₹33568.33
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberV1377
  • Product descriptionVinblastine sulfate salt ≥97% (HPLC)
  • Packaging25MG
  • Price₹46515.03
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberV1377
  • Product descriptionVinblastine sulfate salt ≥97% (HPLC)
  • Packaging50MG
  • Price₹70676.43
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) V1377 Vinblastine sulfate salt ≥97% (HPLC) 1MG ₹4135.15 2022-06-14 Buy
Sigma-Aldrich(India) V1377 Vinblastine sulfate salt ≥97% (HPLC) 5MG ₹12784.33 2022-06-14 Buy
Sigma-Aldrich(India) V1377 Vinblastine sulfate salt ≥97% (HPLC) 10MG ₹20740.7 2022-06-14 Buy
Sigma-Aldrich(India) PHR2698 Vinblastine Sulfate certified reference material, pharmaceutical secondary standard 100MG ₹33568.33 2022-06-14 Buy
Sigma-Aldrich(India) V1377 Vinblastine sulfate salt ≥97% (HPLC) 25MG ₹46515.03 2022-06-14 Buy
Sigma-Aldrich(India) V1377 Vinblastine sulfate salt ≥97% (HPLC) 50MG ₹70676.43 2022-06-14 Buy

Properties

Melting point :267 °C (dec.)(lit.)
alpha :-21.7 º (c=2, CH3OH 21 ºC)
storage temp. :2-8°C
solubility :H2O: 10 mg/mL
form :powder
color :white
PH :3.5～5.0 (1g/l, 25℃)
Water Solubility :>=1 g/100 mL at 24.5 ºC
Merck :13,10044
BRN :3659812
InChIKey :KDQAABAKXDWYSZ-PNYVAJAMSA-N
CAS DataBase Reference :143-67-9(CAS DataBase Reference)
IARC :3 (Vol. 26, Sup 7) 1987
EPA Substance Registry System :Vinblastine sulfate (143-67-9)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Vinblastine, derived from C. roseus, also known as V. rosea, a Madagascar periwinkle, is an antimicrotubule drug used to treat certain cancers, including Hodgkin’s lymphoma, non-small cell lung, breast, head and neck, and testicular cancer. Like its chemical analog vincristine, vinblastine binds tubulin, inhibiting the assembly of microtubules and causing M phase-specific cell cycle arrest by disrupting microtubule assembly and proper formation of the mitotic spindle. It has been shown to inhibit steady-state tubulin addition to microtubules with a Ki value of 0.18 μM, inhibit B16 melanoma cell proliferation with an IC50 value of 1 nM, and produce complete inhibition of L-cell proliferation at 40 nM. Vinblastine is reported to be an effective component of certain chemotherapy regimens, particularly when used with bleomycin and methotrexate in vinblastine, bleomycin, and methotrexate combination chemotherapy for Stage IA or IIA Hodgkin lymphomas.

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Suppliers and manufacturers

Cipla Ltd BDR Pharmaceuticals International Pvt Ltd Zyphars Biopharmaceuticals Pvt. Ltd OCEAN TRADING CORPORATION VINKEM LABS LTD Manus Aktteva CIPLA LIMITED Pharmaffiliates Analytics and Synthetics P. Ltd SynZeal Research Pvt Ltd Rhyme Organics And Chemicals Limited