Vinblastine sulfate
- CAS No.
- 143-67-9
- Chemical Name:
- Vinblastine sulfate
- Synonyms
- VLB;exal;velban;VINCALEUKOBLASTINE;VINBLASTINE SULFATE SALT;velbe;Velsar;29060le;nsc49842;Periblastine
- CBNumber:
- CB7407655
- Molecular Formula:
- C46H60N4O13S
- Molecular Weight:
- 909.05
- MOL File:
- 143-67-9.mol
- Modify Date:
- 2024/8/1 17:24:36
| Melting point | 267 °C (dec.)(lit.) |
|---|---|
| alpha | -21.7 º (c=2, CH3OH 21 ºC) |
| storage temp. | 2-8°C |
| solubility | H2O: 10 mg/mL |
| form | powder |
| color | white |
| PH | 3.5～5.0 (1g/l, 25℃) |
| Water Solubility | >=1 g/100 mL at 24.5 ºC |
| Merck | 13,10044 |
| BRN | 3659812 |
| InChIKey | KDQAABAKXDWYSZ-PNYVAJAMSA-N |
| CAS DataBase Reference | 143-67-9(CAS DataBase Reference) |
| IARC | 3 (Vol. 26, Sup 7) 1987 |
| EPA Substance Registry System | Vinblastine sulfate (143-67-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H341-H361fd | |||||||||
| Precautionary statements | P202-P264-P270-P280-P301+P312-P308+P313 | |||||||||
| Hazard Codes | Xn,T | |||||||||
| Risk Statements | 22-37/38-41-61-36/37/38-63-23/24/25 | |||||||||
| Safety Statements | 26-36/39-53-45-37/39-36/37/39 | |||||||||
| RIDADR | 1544 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YY8400000 | |||||||||
| F | 8-10 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29399990 | |||||||||
| Toxicity | LD50 i.v. in mice: 9.5 mg/kg (Lu, Meistrich) | |||||||||
| NFPA 704 |
|
Vinblastine sulfate price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | V1377 | Vinblastine sulfate salt ≥97% (HPLC) | 143-67-9 | 1MG | ₹4135.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V1377 | Vinblastine sulfate salt ≥97% (HPLC) | 143-67-9 | 5MG | ₹12784.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V1377 | Vinblastine sulfate salt ≥97% (HPLC) | 143-67-9 | 10MG | ₹20740.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V1377 | Vinblastine sulfate salt ≥97% (HPLC) | 143-67-9 | 25MG | ₹46515.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V1377 | Vinblastine sulfate salt ≥97% (HPLC) | 143-67-9 | 50MG | ₹70676.43 | 2022-06-14 | Buy |
Vinblastine sulfate Chemical Properties,Uses,Production
Description
Vinblastine sulfate is the salt of an alkaloid extracted from Vinca rosea Linn., a common flowering herb known as the periwinkle (more properly known as Catharanthus roseus G. Don). Previously, the generic name was vincaleukoblastine, abbreviated VLB. It is a stathmokinetic oncolytic agent. When treated in vitro with this preparation, growing cells are arrested in metaphase. Chemical and physical evidence indicate that vinblastine sulfate is a dimeric alkaloid containing both indole and dihydroindole moieties.
Chemical Properties
Vinblastine sulfate is a white to off-white crystalline powder that is freely soluble in water, soluble in methane, and slightly soluble in ethanol. Its empiric formula is C46H58N4O9.H2SO4 , and it has a molecular weight of 909.07.
Uses
Anticancer agent; microtubule disrupter; Induces apoptosis.Vinblastine sulfate is therapeutically used as an antineoplastic. It is also used in the treatment of Hodgkin disease, choriocarcinoma, acute and chronic leukemias.
General Description
Vinblastine Sulfate is the sulfate salt of vinblastine, a natural alkaloid isolated from the plant Catharanthus roseus (Madagascar periwinkle) with antineoplastic properties. Vinblastine disrupts microtubule formation and function during mitosis and interferes with glutamic acid metabolism. (NCI04)
Air & Water Reactions
Water soluble..Rapidly hydrolyzes.
Reactivity Profile
Vinblastine sulfate is sensitive to light, hydrolysis, oxidation, and heat. Vinblastine sulfate is very hygroscopic. .
Health Hazard
SYMPTOMS: Symptoms of exposure to Vinblastine sulfate include temporary mental depression, paresthesias, loss of deep-tendon reflexes, headache, convulsions, psychoses; dysfunction of the autonomic nervous system, with marked constipation, paralytic ileus, urinary retention, bilateral pain and tenderness of the parotid glands associated with dryness of the mouth, sinus tachycardia; nausea, vomiting, anorexia, diarrhea; loss of hair, vesicular mucositis of the mouth, and dermatitis.
Biological Activity
Anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells.
Safety Profile
Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Human systemic effects by intravenous route: blood leukopenia and hair changes. Experimental reproductive effects. Questionable carcinogen. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also VINCALEUKOBLASTINE and SULFATES.
Purification Methods
Crystallise the sulfate from MeOH or EtOH and dry it in vacuo over conc H2SO4. The free base crystallises from EtOH or MeOH m 211-216o (+ 2MeOH .1 H2O) and forms a stable etherate from Et2O with m 201-211o, and [] D +42o (CHCl3), and UV max at 214 and 259nm (log 4.73 and 4.21). The dihydrochloride has m 244-246o(dec)(MeOH). It is a monoamine oxidase B inhibitor and induces microtubule aggregation. It is an antineoplastic drug for Hodgkin’s lymphoma. [Neuss et al. J Am Chem Soc 81 4754 1959, Jong-KeunSon et al. J Med Chem 33 1845 1990, Warfield & Bouck Science 186 1219 1974, Beilstein 26 III/IV 3167.]
Vinblastine sulfate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| BDR Pharmaceuticals International Pvt Ltd | +91-2240560560 +91-7718884418 | Maharashtra, India | 206 | 58 | Inquiry |
| Zyphars Biopharmaceuticals Pvt. Ltd | +91-8007587007 +91-8007587007 | Mumbai, India | 14 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| VINKEM LABS LTD | +91 44 27661003 | New Delhi, India | 3 | 30 | Inquiry |
| Manus Aktteva | +91 (79) 6512-3395 | New Delhi, India | 581 | 34 | Inquiry |
| CIPLA LIMITED | +91 22 24826000 | New Delhi, India | 72 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Rhyme Organics And Chemicals Limited | 08048372046Ext 929 | Hyderabad, India | 102 | 58 | Inquiry |
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