2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE
![2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE Structure](/CAS/GIF/182004-65-5.gif)
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- ₹7000 - ₹12500
- Product name: 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE
- CAS: 182004-65-5
- MF: C17H21N3O6S2
- MW: 427.49
- EINECS:
- MDL Number:MFCD00952138
- Synonyms:Carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester methanesulfonate;Carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester monomethanesulfonate;KB-R7943;KB-R7943 MESYLATE;2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE;2-(2-(4-(4-NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA, METHANE SULFONATE;S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate;4-((4-Nitrobenzyl)oxy)phenethyl carbaMiMidothioate Methanesulfonate
2 prices
Selected condition：
Brand
- TCI Chemicals (India)
Package
- 10MG
- 50MG
- ManufacturerTCI Chemicals (India)
- Product numberN0966
- Product descriptionKB-R 7943
- Packaging10MG
- Price₹7000
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberN0966
- Product descriptionKB-R 7943
- Packaging50MG
- Price₹12500
- Updated2022-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | N0966 | KB-R 7943 | 10MG | ₹7000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | N0966 | KB-R 7943 | 50MG | ₹12500 | 2022-05-26 | Buy |
Properties
Melting point :>214°C (dec.)
storage temp. :Inert atmosphere,2-8°C
solubility :Soluble in DMSO (up to 50 mg/ml).
form :White crystalline solid
color :Tan
Water Solubility :water: 4mg/mL
DMSO: 40mg/mL Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
storage temp. :Inert atmosphere,2-8°C
solubility :Soluble in DMSO (up to 50 mg/ml).
form :White crystalline solid
color :Tan
Water Solubility :water: 4mg/mL
DMSO: 40mg/mL Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
The Na+/Ca2+ exchanger (NCX) is a major regulator of intracellular calcium concentration that is largely expressed in cardiac sarcolemma (NCX1) but also in brain and skeletal muscle (NCX2). KB-R7943 is an isothiourea derivative that selectively inhibits the reverse mode of NCX1 (IC50 = 1.2-2.4 μM), preventing intracellular sodium-dependent calcium uptake in whole cells. It is much less potent at preventing extracellular sodium-dependent calcium efflux from intact cells (IC50 > 30 μM). In cultured hippocampal neurons, KB-R7943 exhibits neuroprotection from glutamate-induced excitotoxicity by blocking NMDA receptor-mediated activity (IC50 = 13.4 μM) and inhibiting complex I in the mitochondrial respiratory chain (IC50 = 11.4 μM). KB-R7943 has also been shown to block transient receptor potential canonical channels, which are important mediators of calcium-dependent signal transduction.Related product price
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![2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE](https://img.chemicalbook.com/ProductImageEN/2020-1/small/7ef85ae9-c56c-418c-a202-ae81fb168270.jpg){kind=small}
