xav-939
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- ₹9006.4 - ₹35062.18
- Product name: xav-939
- CAS: 284028-89-3
- MF: C14H11F3N2OS
- MW: 312.31
- EINECS:687-302-1
- MDL Number:MFCD00106866
- Synonyms:2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-3H-thiopyrano[4,3-d]pyrimidin-4(5H)-one;XAV-939;XAV 939;xav-939;3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one;XAV 939/NVP-XAV939;XAV 939, >=98%;SteMolecule;1,5,7,8-Tetrahydro-2-[4-(trifluoroMethyl)phenyl]-4H-thiopyrano[4,3-d]pyriMidin-4-one
3 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- 100MG
- ManufacturerTCI Chemicals (India)
- Product numberX0077
- Product descriptionXAV 939
- Packaging100MG
- Price₹27300
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberX3004
- Product descriptionXAV939 ≥98% (HPLC)
- Packaging25MG
- Price₹35062.18
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberX3004
- Product descriptionXAV939 ≥98% (HPLC)
- Packaging5MG
- Price₹9006.4
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | X0077 | XAV 939 | 100MG | ₹27300 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | X3004 | XAV939 ≥98% (HPLC) | 25MG | ₹35062.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | X3004 | XAV939 ≥98% (HPLC) | 5MG | ₹9006.4 | 2022-06-14 | Buy |
Properties
Boiling point :429.3±55.0 °C(Predicted)
Density :1.5
Flash point :213.4℃
storage temp. :room temp
solubility :DMSO: soluble5mg/mL, clear
form :powder
pka :0.23±0.20(Predicted)
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Density :1.5
Flash point :213.4℃
storage temp. :room temp
solubility :DMSO: soluble5mg/mL, clear
form :powder
pka :0.23±0.20(Predicted)
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
The Wnt signaling pathway is integral to normal biological processes and inappropriately active in many cancers. It is regulated through degradation of the downstream effector β-catenin via a complex consisting of the tumor suppressor APC, axin, and glycogen synthase kinase 3 (GSK3). Axin is the concentration-limiting factor for this degradation complex. Initially indentified as telomere-associated proteins, tankyrases promote axin ubiquitination, possibly through poly-ADP-ribosylation (PARsylation). XAV939 is a potent, small molecule inhibitor of tankyrase (TNKS) 1 and 2 with IC50 values of 11 and 4 nM, respectively. By inhibiting TNKS activity, XAV939 increases the protein levels of the axin-GSK3β complex and promotes the degradation of β-catenin in SW480 cells. At concentrations as low as 0.33 μM, XAV939 inhibits colony formation of APC-deficient colorectal cancer cells.More related product prices
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