Ko 143
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- ₹12697.73 - ₹50379.55
- Product name: Ko 143
- CAS: 461054-93-3
- MF: C26H35N3O5
- MW: 469.57
- EINECS:
- MDL Number:MFCD11042273
- Synonyms:Pyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid, 1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxo-, 1,1-dimethylethyl ester, (3S,6S,12aS)-(Ko143);Ko 143;(3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester;12a-octahydro-9-Methoxy-6-(2-Methylpropyl)-1;12aS)-;4-b]indole-3-propanoicacid;4-dioxo-;6]pyrido[3
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberK2144
- Product descriptionKo143 hydrate ≥98% (HPLC)
- Packaging1MG
- Price₹12697.73
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberK2144
- Product descriptionKo143 hydrate ≥98% (HPLC)
- Packaging5MG
- Price₹50379.55
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | K2144 | Ko143 hydrate ≥98% (HPLC) | 1MG | ₹12697.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | K2144 | Ko143 hydrate ≥98% (HPLC) | 5MG | ₹50379.55 | 2022-06-14 | Buy |
Properties
Melting point :147 ºC
Boiling point :689.8±55.0 °C(Predicted)
Density :1.24
storage temp. :Desiccate at -20°C
solubility :DMSO: >10mg/mL
form :powder
pka :13.31±0.60(Predicted)
color :white to off-white
Stability :Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Boiling point :689.8±55.0 °C(Predicted)
Density :1.24
storage temp. :Desiccate at -20°C
solubility :DMSO: >10mg/mL
form :powder
pka :13.31±0.60(Predicted)
color :white to off-white
Stability :Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Breast cancer resistance protein (BCRP) is an ATP-binding cassette protein known also as ABCG2. While it normally functions as a high-capacity urate exporter in the renal system, it also acts as a xenobiotic transporter and contributes to multidrug resistance (e.g., to mitoxantrone) in certain types of cancer. BCRP is abundant at the intestinal epithelium and blood-brain barrier, potentially restricting the distribution of certain drugs. Ko 143 is a potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell lines (EC50s = 23 and 26 nM, respectively). It is much less effective at the transporters P-glycoprotein and multidrug resistance-associated protein 1, MRP1. Ko 143 is effective in vivo in mice.Related product price
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