Phenformin hydrochloride
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- ₹3399.05 - ₹11961.63
- Product name: Phenformin hydrochloride
- CAS: 834-28-6
- MF: C10H16ClN5
- MW: 241.72
- EINECS:212-637-3
- MDL Number:MFCD00035039
- Synonyms:1-(diaminomethylene)-2-phenethylguanidine hydrochloride;1-(diaminomethylene)-2-phenethyl-guanidine hydrochloride;1-(diaminomethylidene)-2-phenethylguanidine hydrochloride;1-(diaminomethylidene)-2-phenethyl-guanidine hydrochloride;1-Fenetilbiguanide cloridrato [Italian];1-Phen;meltrol ;n-(2-phenylethyl)-imidodicarbonimidicdiamidmonohydrochloride
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 500MG
- 1G
- 10G
- ManufacturerSigma-Aldrich(India)
- Product numberPHR1573
- Product descriptionPhenformin Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging500MG
- Price₹11961.63
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberP7045
- Product descriptionPhenformin hydrochloride analytical standard
- Packaging10G
- Price₹10608.5
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberP7045
- Product descriptionPhenformin hydrochloride analytical standard
- Packaging1G
- Price₹3399.05
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1573 | Phenformin Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 500MG | ₹11961.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P7045 | Phenformin hydrochloride analytical standard | 10G | ₹10608.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P7045 | Phenformin hydrochloride analytical standard | 1G | ₹3399.05 | 2022-06-14 | Buy |
Properties
Melting point :175-178°C
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :Methanol (Slightly), Water (Slightly)
form :Solid
color :White to Off-White
Water Solubility :>=10 g/100 mL at 21 ºC
CAS DataBase Reference :834-28-6(CAS DataBase Reference)
EPA Substance Registry System :Phenformin hydrochloride (834-28-6)
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :Methanol (Slightly), Water (Slightly)
form :Solid
color :White to Off-White
Water Solubility :>=10 g/100 mL at 21 ºC
CAS DataBase Reference :834-28-6(CAS DataBase Reference)
EPA Substance Registry System :Phenformin hydrochloride (834-28-6)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Phenformin is an orally administered biguanide derivative with potential to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus. In general, biguanides improve insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase (AMPK)-dependent signaling. Phenformin, however, has been withdrawn from clinical use because it also inhibits peripheral glucose oxidation and has an associated effect of inducing lactic acidosis when not metabolized sufficiently. Through AMPK activation, phenformin at 300 mg/kg exhibits anticancer activity by inhibiting the growth of MCF-7 and MDAMB231 breast cancer cell xenografts in mice.More related product prices
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