Amlodipine
- ₹0
- Product name: Amlodipine
- CAS: 88150-42-9
- MF: C20H25ClN2O5
- MW: 408.88
- EINECS:1308068-626-2
- MDL Number:MFCD00864687
- Synonyms:AMLODIPINE MM(CRM STANDARD);Amlodipine∬AmlodipineBesylate/Maleate;3,5-Pyridinedicarboxylic acid, 2-(2-aminoethoxy)methyl-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester;ethyl methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate;Pelmec;Racemic Amlodipine;3,5-pyridinedicarboxylic acid, 1,4-dihydro-2-((2-aminoethoxy)methyl)-4-(2-chlor 3-ethyl 5-methyl ester
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|
Properties
Melting point :178-179°C
Boiling point :527.2±50.0 °C(Predicted)
Density :1.227±0.06 g/cm3(Predicted)
RTECS :US7968329
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to 25 mg/ml), in DMF (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
pka :pKa 8.6 (Uncertain)
form :Almost white crystal powder
color :White
Water Solubility :75.3 mg/L
BCS Class :1
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference :88150-42-9(CAS DataBase Reference)
EPA Substance Registry System :3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester (88150-42-9)
Boiling point :527.2±50.0 °C(Predicted)
Density :1.227±0.06 g/cm3(Predicted)
RTECS :US7968329
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to 25 mg/ml), in DMF (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
pka :pKa 8.6 (Uncertain)
form :Almost white crystal powder
color :White
Water Solubility :75.3 mg/L
BCS Class :1
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference :88150-42-9(CAS DataBase Reference)
EPA Substance Registry System :3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester (88150-42-9)
Safety Information
Symbol(GHS): | |||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Warning | ||||||||||||||||||||||||||||||||||||||||||
Hazard statements: |
|
||||||||||||||||||||||||||||||||||||||||||
Precautionary statements: |
|
Description
Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle. Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC50 value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues. When used in combination with the angiotensin receptor blocker olmesartan, amlopidine has been shown to potentiate antihypertensive activity. Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition.More related product prices
2,6-Dimethyl-7-octen-2-ol Triethyl orthoformate Diethyl azodicarboxylate Methyl acetate Picolinic acid Urethane Methylparaben Acetonitrile Diethyl phthalate Paraquat dichloride Kresoxim-methyl Chromium picolinate Ethyl formate Methyl acrylate Methanol Levetiracetam Ethyl chloroformateRelated product price
- Triethyl orthoformate
₹1312-25777 - Diethyl azodicarboxylate
₹2591-22509 - Methyl acetate
₹567-42314.93