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Phenformin hydrochloride

Phenformin hydrochloride Structure
CAS No.
834-28-6
Chemical Name:
Phenformin hydrochloride
Synonyms
1-Phen;dbi-td;Insora;meltrol;usafvi-6;Glucopostin;PHENFORMIN HCL;Phenformine HCL;PhenforMin HCl API;phenforminhclno.9113
CBNumber:
CB2280910
Molecular Formula:
C10H16ClN5
Molecular Weight:
241.72
MOL File:
834-28-6.mol
Modify Date:
2024/7/2 8:55:03

Phenformin hydrochloride Properties

Melting point 175-178°C
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Methanol (Slightly), Water (Slightly)
form Solid
color White to Off-White
Water Solubility >=10 g/100 mL at 21 ºC
CAS DataBase Reference 834-28-6(CAS DataBase Reference)
EPA Substance Registry System Phenformin hydrochloride (834-28-6)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
WGK Germany  3
RTECS  DU2200000
HS Code  29252900
Toxicity LD50 in mice (mg/kg): 19 i.v., 450 orally; in rats: 1050 orally; in guinea pigs: 47 orally, 19 s.c. (Proske)
NFPA 704
0
2 0

Phenformin hydrochloride price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) P7045 Phenformin hydrochloride analytical standard 834-28-6 1G ₹3399.05 2022-06-14 Buy
Sigma-Aldrich(India) PHR1573 Phenformin Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 834-28-6 500MG ₹11961.63 2022-06-14 Buy
Sigma-Aldrich(India) P7045 Phenformin hydrochloride analytical standard 834-28-6 10G ₹10608.5 2022-06-14 Buy
Product number Packaging Price Buy
P7045 1G ₹3399.05 Buy
PHR1573 500MG ₹11961.63 Buy
P7045 10G ₹10608.5 Buy

Phenformin hydrochloride Chemical Properties,Uses,Production

Description

Phenformin is an orally administered biguanide derivative with potential to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus. In general, biguanides improve insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase (AMPK)-dependent signaling. Phenformin, however, has been withdrawn from clinical use because it also inhibits peripheral glucose oxidation and has an associated effect of inducing lactic acidosis when not metabolized sufficiently. Through AMPK activation, phenformin at 300 mg/kg exhibits anticancer activity by inhibiting the growth of MCF-7 and MDAMB231 breast cancer cell xenografts in mice.

Chemical Properties

White Crystalline Solid

General Description

White solid or powder. Formerly used as an anti-diabetic drug. Toxic (causes lactic acidosis.

Air & Water Reactions

Water soluble.

Reactivity Profile

Phenformin hydrochloride gives weakly acidic aqueous solutions. May react with strong oxidizing agents.

Fire Hazard

Flash point data for Phenformin hydrochloride are not available; however, Phenformin hydrochloride is probably combustible.

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Phenformin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 234)Suppliers
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A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21670 55 Inquiry
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Hebei Guanlang Biotechnology Co., Ltd. +86-19930503282 China 8826 58 Inquiry
Xiamen AmoyChem Co., Ltd +86-592-6051114 +8618959220845 China 6387 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
SIMAGCHEM CORP +86-13806087780 China 17367 58 Inquiry
1-(diaminomethylene)-2-phenethylguanidine hydrochloride 1-(diaminomethylene)-2-phenethyl-guanidine hydrochloride 1-(diaminomethylidene)-2-phenethylguanidine hydrochloride 1-(diaminomethylidene)-2-phenethyl-guanidine hydrochloride 1-Fenetilbiguanide cloridrato [Italian] 1-Phen meltrol n-(2-phenylethyl)-imidodicarbonimidicdiamidmonohydrochloride n(sup1)-beta-phenethylbiguanidehydrochloride n’-beta-phenethylbiguanidehydrochloride n-beta-phenylethylbiguanidehydrochloride phenforminhclno.9113 phenoforminehydrochloride 1-phenethylbiguanide hydrochloride 1-fenetilbiguanidecloridrato 1-phenethyl-biguanidhydrochloride 1-phenethyl-biguanidmonohydrochloride 1-phenylaethylbiguanidhydrochlorid dbi-td usafvi-6 Phenformine HCL PHENFORMINI HYDROCHLORIDE Insora N-(2-Phenylethyl)imidodicarbonimidic Diamide Hydrochloride BIGUANIDE,1-PHENETHYL-,MONOHYDROCHLORIDE PHENFORMIN HCL PHENFORMIN HYDROCHLORIDE PHENETHYLBIGUANIDE HYDROCHLORIDE Phenformin Hydrochloride (200 mg) 1-(2-Phenylethyl)biguanide hydrochloride Glucopostin Imidodicarbonimidic diamide, N-(2-phenylethyl)-, monohydrochloride PhenforMin HCl API N-(2-phenylethyl)-imidodicarbonimidic diamide, hydrochloride (1:1) N-(2-Phenylethyl)imidodicarbonimidic diamide monohydrochloride Phenformin hydrochlorid 1-(diaminomethylidene)-2-(2-phenylethyl)guanidine chloride Phenformin hydrochloride salt Phenformin hydrochloride solution in Methanol,1000ug/ml 1-Carbamimidamido-N-(2-phenylethyl)methanimidamide Hydrochloride PHENFORMIN HYDROCHLORIDE/834-28-6 Phenformin hydrochloride USP/EP/BP Phenformin HydrochlorideQ: What is Phenformin Hydrochloride Q: What is the CAS Number of Phenformin Hydrochloride Q: What is the storage condition of Phenformin Hydrochloride Q: What are the applications of Phenformin Hydrochloride 1-Carbamimidamido-N-(2-phenylethyl)methanimidamide Hydrochloride[Phenethylbiguanide Hydrochloride 1-phenethylbiguanide hcl Amphetamine Impurity 4 (Amphetamine EP Impurity D) Phenformin (NSC-756501) HCl 834-28-6 C10H15N5HClC10H16ClN5 C10H16ClN5 C10H15N5HCl 24172 AMINE Alphabetic PEM - POLA Analytical Chromatography Product Catalog Analytical Standards Inhibitors