ChemicalBook > Product Catalog >API >Antineoplastic agents >Antibiotics anticancer drugs >Epirubicin hydrochloride
Epirubicin hydrochloride
- CAS No.
- 56390-09-1
- Chemical Name:
- Epirubicin hydrochloride
- Synonyms
- Ebewe;Adrial;Ellence;CS-1396;Epirubin HCI;Farmorubicin-RTU;Epirubicin Ebewe;EpirubicinHc,LEp5,;Epirubicin HCl API;(8s-cis)-rochlorid
- CBNumber:
- CB3501568
- Molecular Formula:
- C27H30ClNO11
- Molecular Weight:
- 579.9802
- MOL File:
- 56390-09-1.mol
- Modify Date:
- 2024/3/22 14:56:24
| Melting point | 185°C dec. |
|---|---|
| alpha | D20 +274° (c = 0.01 in methanol) |
| RTECS | QI9295750 |
| Flash point | 443.8℃ |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Soluble in DMSO to 100mM, or in ethanol to 10mM |
| form | powder |
| color | red to deep red |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. |
| InChIKey | MWWSFMDVAYGXBV-UAOJCOQHSA-N |
| SMILES | C12=C(O)C3=C(C(=O)C4=C(C3=O)C=CC=C4OC)C(O)=C1[C@@]([H])(O[C@H]1O[C@@H](C)[C@H](O)[C@@H](N)C1)C[C@](O)(C(=O)CO)C2.Cl |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H340-H350-H360 | |||||||||
| Precautionary statements | P201-P301+P312+P330-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-63-62-46-40 | |||||||||
| Safety Statements | 36/37/38-45-46 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29419090 | |||||||||
| NFPA 704 |
|
Epirubicin hydrochloride price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | E9406 | Epirubicin hydrochloride ≥90% (HPLC) | 56390-09-1 | 5MG | ₹11990 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E9406 | Epirubicin hydrochloride ≥90% (HPLC) | 56390-09-1 | 10MG | ₹32300 | 2022-06-14 | Buy |
| SRL | 97857 | Epirubicin Hydrochloride (EPR.HCl), 97% | 56390-09-1 | 10mg | ₹5340 | 2022-05-26 | Buy |
| SRL | 97857 | Epirubicin Hydrochloride (EPR.HCl), 97% | 56390-09-1 | 25mg | ₹10680 | 2022-05-26 | Buy |
Epirubicin hydrochloride Chemical Properties,Uses,Production
Description
Epirubicin hydrochloride is an antitumor antibiotic which is epimeric with doxorubicin a t the 4’-position of the amino sugar moiety. It has shown utility in the treatment of mammary, gastric, colorectal, pulmonary and ovarian carcinomas, as well as malignant lymphoma and melanoma and soft tissue sarcoma. It is reported to be less sardiotoxic than doxorubicin.
Chemical Properties
Orange-Red Crystalline Solid
Uses
Used as an antineoplastic
Biological Functions
This stereoisomer of doxorubicin has the 4′-hydroxy group of the daunosamine sugar oriented in the β-position . Epirubicin will be slowly reduced to the active C13 alcohol (epirubicinol), giving it a 30- to 38-hour half life, which is similar to that of doxorubicin. Unlike doxorubicinol, however, which was equally active with doxorubicin, epirubicinol has only one-tenth the activity of its parent drug and is not believed to contribute significantly to the therapeutic action of this agent.
Biological Activity
Antibiotic antitumor agent. Inhibits the synthesis and function of DNA (IC 50 = 62.7 μ M in rat glioblastoma cell lines) and inhibits the relaxing property of topoisomerase II.
Clinical Use
Epirubicin is indicated for use in breast cancer, and the starting dose is 100 to 120 mg/m2 (compared to a starting dose of 60–75 mg/m2 for doxorubicin).
Side effects
The side effects and precautions are as outlined previously for doxorubicin, although there is a lower risk of serious myocardial toxicity or myelotoxicity.
Metabolism
Cleavage of the epimerized sugar will occur before excretion, generating an aglycone that is indistinguishable from that generated by doxorubicin. Although excretion is primarily biliary, dosage reduction in severe renal impairment, as well as in hepatic dysfunction, is warranted.
Epirubicin hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 423)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BDR Pharmaceuticals International Pvt Ltd | +91-2240560560 +91-7718884418 | Maharashtra, India | 206 | 58 | Inquiry |
| Sakar Healthcare | +91-8976292690 +91-9967572302 | Gujarat, India | 47 | 58 | Inquiry |
| Euroasia Trans Continental | +91 22 56349035-36 | New Delhi, India | 519 | 47 | Inquiry |
| Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group) | 91-22-42361111 | Maharashtra, India | 147 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Shreesurya Pharma Private Limited | 08048371511Ext 263 | Mumbai, India | 4 | 58 | Inquiry |
| Meridian Medicine Pharma | 08046039854 | Nagpur, India | 1 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
56390-09-1(Epirubicin hydrochloride)Related Search:
chevron_left
1of4
chevron_right
4’-epi-adriamycinhydrochloride
5,12-naphthacenedione,10-((3-amino-2,3,6-trideoxy-alpha-l-arabino-hexopyranosy
8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-l)oxy)-hyd
EPIRUBICIN HYDROCHLORIDE EP STANDARD
EpirubicinHc,LEp5,
Adrial
(8S,10S)-10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione, hydrochloride (1:1)
5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
(8S,10S)-10-(((2S,4S,5R,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-tri
Ellence, Farmorubicin, Pharmorubicin
5,12-Naphthacenedione, 10-(3-amino-2,3,6-trideoxy-.alpha.-L-arabino-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
Epidoxorubicin hydrochloride
(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
Epirubicin hydrochloride
Farmorubicin-RTU
Epirubicin hydrochloride(4'-Epidoxorubicin)
Ellence
Epirubicin, Hydrochloride Salt
Epirubicin Hydrochloride (200 mg)
(8S-cis)-4'-Epidoxorubicin Hydrochloride
Epirubicin HCl API
(8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedionehydrochloride
Epirubin HCI
Epirubicin hydrochloride, >=99%
Epirubicin HCl
Epirubicin hydrochloride
(8s-cis)-rochlorid
Epirubicin hydrochloride CRS
(8S,10S)-10-(((2R,4S,5R,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride
Epirubicin hydrochloride USP/EP/BP
cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid
Epirubicin hydrochloride / Epirubicin hcl
(8R,10S)-10-{[(2R,4S,5R,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-7-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione
Epirubicin HydrochlorideQ: What is
Epirubicin Hydrochloride Q: What is the CAS Number of
Epirubicin Hydrochloride Q: What is the storage condition of
Epirubicin Hydrochloride Q: What are the applications of
Epirubicin Hydrochloride
5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
Epirubicin Hydrochloride (EPR.HCl), 97%
Epirubicin Hydrochloride (1237382)
CS-1396
Epirubicin hydrochloride, ≥90% (HPLC)
Epirubicin Hydrochloride - CAS 56390-09-1 - Calbiochem
epi-Doxorubicin HCl
Epirubicin HCl (4'-epidoxorubicin)
ELLENCE; PHARMORUBICIN; EPIRUBICIN EBEWE
Epirubicin Ebewe
(8S,10S)-10-(((2R,4S,5R,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride (Doxorubicin Impurity)
Ebewe
Epirubicin (IMI 28) HCl
(8R,10S)-10-{[(2R,4S,5R,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-7-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,1
56390-09-1
C27H28NO11xHCl
C27H34ClNO11
C27H33NO11
57998
Anti-cancer&immunity
API
Antineoplastic
Intermediates & Fine Chemicals