Benzhexol hydrochloride
- CAS No.
- 52-49-3
- Chemical Name:
- Benzhexol hydrochloride
- Synonyms
- tremin;win511;Trihexy;Sedrina;Broflex;peragit;pipanol;Aparkane;Antitrem;Parkidyl
- CBNumber:
- CB4447818
- Molecular Formula:
- C20H31NO.ClH
- Molecular Weight:
- 337.93
- MOL File:
- 52-49-3.mol
- Modify Date:
- 2023/12/13 11:21:46
| Melting point | Free base, mp 114.3-115.0° |
|---|---|
| Density | 0.9801 (rough estimate) |
| refractive index | 1.5790 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: soluble |
| form | solid |
| color | white |
| Water Solubility | 670.9ug/L(22.5 ºC) |
| Merck | 14,9695 |
| Stability | Stable at RT, Stable At Rt |
| InChI | InChI=1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H |
| InChIKey | QDWJJTJNXAKQKD-UHFFFAOYSA-N |
| SMILES | C(O)(CCN1CCCCC1)(C1CCCCC1)C1C=CC=CC=1.Cl |
| CAS DataBase Reference | 52-49-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 36 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TN2625000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933399090 | |||||||||
| Toxicity | TDLo orl-wmn: 800 mg/kg:BAH BJPYAJ 145,300,84 | |||||||||
| NFPA 704 |
|
Benzhexol hydrochloride Chemical Properties,Uses,Production
Description
Trihexyphenidyl is an antagonist of M1 muscarinic acetylcholine receptors. It binds to rat M1 receptors in cerebral cortex selectively over rat M2 receptors in heart tissue (IC50s = 3.7 and 31 nM, respectively). Trihexyphenidyl inhibits contractions induced by acetylcholine in guinea pig ileum (IC50 = 22 nM). It also inhibits oxotremorine-induced tremors and physostigmine-induced mortality in mice (ED50s = 2 and 3.6 mg/kg, respectively). Trihexyphenidyl (20 mg/kg) improves abnormal movement in a mouse model of L-3,4-dihydroxyphenylalanine (L-DOPA) responsive dystonia (DRD) that expresses mutant tyrosine hydroxylase (TH). Formulations containing trihexyphenidyl have been used in the symptomatic treatment of Parkinson''s disease.
Chemical Properties
Benzhexol hydrochloride is White Solid
Uses
Benzhexol hydrochloride is an anticholinergic tertiary amine that can gain access to the CNS. It is used to treat parkinsonism and the extrapyramidal side effects of anti-psychotic drugs. The drug is a muscarinic anta gonist that qualitatively resembles the belladonna alkaloids in its pharmacological actions and side effects.
General Description
Trihexyphenidylhydrochloride, α-cyclohexyl-α-phenyl-1-piperidinepropanolhydrochloride (Artane, Tremin, Pipanol), introduced in1949, is approximately half as active as atropine as an antispasmodicbut is claimed to have milder side effects, such asmydriasis, drying of secretions, and cardioacceleration. It hasa good margin of safety, although it is about as toxic as atropine.It has found a place in the treatment of parkinsonismand is claimed to provide some measure of relief from themental depression often associated with this condition. It does, however, exhibit some of the side effects typical of theparasympatholytic-type preparation, although adjusting thedose carefully may often eliminate these.
Side effects
Common side effects of Benzhexol hydrochloride include drowsiness, dizziness, constipation, flushing, nausea, nervousness, blurred vision or dry mouth. Severe may include: decreased sexual performance, severe stomach/abdominal pain, difficulty/pain in swallowing, difficulty in urinating, chest pain, severe dizziness/fainting, high fever, fast/irregular/slow heartbeat, mental/mood changes (e.g., blurred consciousness, hallucinations, memory problems), pain/swelling/reddening of the eyes, changes in vision (e.g., seeing rainbows around lights at night). Symptoms of very severe allergic reactions in some patients include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, and difficulty breathing. In addition, studies have shown that Benzhexol hydrochloride has minimal side effects in the treatment of salivation in children with cerebral palsy.
Safety Profile
Poison by ingestion,intraperitoneal, intravenous, and subcutaneous routes. Ananticholinergic agent which causes human psychotropiceffects. Human systemic effects by ingestion: distortedperceptions, eye effects, hallucinations, toxic psychosis.When he
Benzhexol hydrochloride Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| Anugraha Chemicals | +91-8041685494 +91-9845939733 | Karnataka, India | 22 | 58 | Inquiry |
| Vachichem | +91-9886704423 +91-9880599557 | Karnataka, India | 72 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Besil Chem LLP | +91-7760252666 +91-9880731835 | Bangalore, India | 163 | 58 | Inquiry |
| Dy - Mach Pharma | +91-2265018321 +91-2226833227 | Maharashtra, India | 18 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| R L Fine Chem Pvt. Ltd | +91-8042488999 +91-8042488999 | Karnataka, India | 74 | 58 | Inquiry |
| Sibram Pharmaceutical | +91-8655777550 +91-8655777550 | Maharashtra, India | 244 | 58 | Inquiry |
| Harika Drugs Pvt Ltd | +91-4023814863 +91-4023814863 | Telangana, India | 19 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Jigs Chemical ltd | 58 |
| Anugraha Chemicals | 58 |
| Vachichem | 58 |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | 58 |
| Besil Chem LLP | 58 |
| Dy - Mach Pharma | 58 |
| Ralington Pharma | 58 |
| R L Fine Chem Pvt. Ltd | 58 |
| Sibram Pharmaceutical | 58 |
| Harika Drugs Pvt Ltd | 58 |