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ChemicalBook > Product Catalogue >API >Nervous system drugs >Antiparkinson Drugs >Benzhexol hydrochloride

Benzhexol hydrochloride

Benzhexol hydrochloride Structure
  • ₹0
  • Product name: Benzhexol hydrochloride
  • CAS: 52-49-3
  • MF: C20H31NO.ClH
  • MW: 337.93
  • EINECS:200-142-5
  • MDL Number:MFCD00058212
  • Synonyms:Antitrem;Aparkane;Broflex;Parkidyl;Parkinane;Parkisan;Partigan;Sedrina
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :Free base, mp 114.3-115.0°
Density :0.9801 (rough estimate)
refractive index :1.5790 (estimate)
storage temp. :Inert atmosphere,Room Temperature
solubility :H2O: soluble
form :solid
color :white
Water Solubility :670.9ug/L(22.5 ºC)
Merck :14,9695
Stability :Stable at RT, Stable At Rt
InChI :InChI=1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H
InChIKey :QDWJJTJNXAKQKD-UHFFFAOYSA-N
SMILES :C(O)(CCN1CCCCC1)(C1CCCCC1)C1C=CC=CC=1.Cl
CAS DataBase Reference :52-49-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501 Dispose of contents/container to..…

Description

Trihexyphenidyl is an antagonist of M1 muscarinic acetylcholine receptors. It binds to rat M1 receptors in cerebral cortex selectively over rat M2 receptors in heart tissue (IC50s = 3.7 and 31 nM, respectively). Trihexyphenidyl inhibits contractions induced by acetylcholine in guinea pig ileum (IC50 = 22 nM). It also inhibits oxotremorine-induced tremors and physostigmine-induced mortality in mice (ED50s = 2 and 3.6 mg/kg, respectively). Trihexyphenidyl (20 mg/kg) improves abnormal movement in a mouse model of L-3,4-dihydroxyphenylalanine (L-DOPA) responsive dystonia (DRD) that expresses mutant tyrosine hydroxylase (TH). Formulations containing trihexyphenidyl have been used in the symptomatic treatment of Parkinson''s disease.

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Suppliers and manufacturers

Jigs Chemical ltd Anugraha Chemicals Vachichem Rivashaa Agrotech Biopharma Pvt. Ltd. Besil Chem LLP Dy - Mach Pharma Ralington Pharma R L Fine Chem Pvt. Ltd Sibram Pharmaceutical Harika Drugs Pvt Ltd