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ml390

ml390 Structure
CAS No.
2029049-79-2
Chemical Name:
ml390
Synonyms
ml390;(R)-N-(3-Oxo-3-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)propyl)-4-(trifluoromethoxy)benzamide;Benzamide, N-[3-oxo-3-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]propyl]-4-(trifluoromethoxy)-;ER-HoxA9,Dihydroorotate Dehydrogenase,inhibit,AML,ML 390,differentiatio,U937,DHODH,ML390,myeloid,ML-390,Inhibitor,THP1
CBNumber:
CB43145908
Molecular Formula:
C21H21F3N2O3
Molecular Weight:
406.4
MOL File:
2029049-79-2.mol
Modify Date:
2024/7/2 8:55:08
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ml390 Properties

Boiling point 599.7±50.0 °C(Predicted)
Density 1.31±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≥40.6 mg/mL in DMSO; insoluble in H2O; ≥17.47 mg/mL in EtOH
form solid
pka 13.65±0.46(Predicted)
color White to off-white

ml390 Chemical Properties,Uses,Production

Description

ML-390 is an inhibitor of dihydroorotate dehydrogenase (DHODH), the enzyme that converts dihydroorotate to orotate during de novo pyrimidine synthesis. In acute myeloid leukemia, leukemic myeloblast development is halted at an immature stage leading to perpetual self-renewal rather than differentiation. ML-390 induces differentiation in the acute myeloid leukemia cell lines U937 (murine) and THP-1 (human) cell lines with an EC50 value of approximately 2 μM.

ml390 Preparation Products And Raw materials

Raw materials

Preparation Products

ml390 Suppliers

Global( 37)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Shanghai Aladdin Biochemical Technology Co.,Ltd. +86-18521732826 China 48467 58 Inquiry
Chunchuang (Wuhan) Technology Co., Ltd 15342225168 China 10005 58 Inquiry
Bide Pharmatech Ltd. 400-1647117 15221909166 China 63720 58 Inquiry
InvivoChem 13549236410 China 6747 58 Inquiry
Shanghai Dongyang Biotechnology Co., Ltd. 0512-0512-13601744364 13601744364 China 896 58 Inquiry
BOC Sciences USA 0 65 Inquiry
Supplier Advantage
BOC Sciences 58
TargetMol Chemicals Inc. 58
InvivoChem 58
Aladdin Scientific 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 58
Chunchuang (Wuhan) Technology Co., Ltd 58
Bide Pharmatech Ltd. 58
InvivoChem 58
Shanghai Dongyang Biotechnology Co., Ltd. 58
BOC Sciences 65

ml390 Spectrum

ml390(2029049-79-2)1HNMR

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ml390 Benzamide, N-[3-oxo-3-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]propyl]-4-(trifluoromethoxy)- ER-HoxA9,Dihydroorotate Dehydrogenase,inhibit,AML,ML 390,differentiatio,U937,DHODH,ML390,myeloid,ML-390,Inhibitor,THP1 (R)-N-(3-Oxo-3-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)propyl)-4-(trifluoromethoxy)benzamide 2029049-79-2