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NIGERICIN SODIUM SALT

NIGERICIN SODIUM SALT Structure
CAS No.
28380-24-7
Chemical Name:
NIGERICIN SODIUM SALT
Synonyms
x-464;Helix c;HELIXIN C;NIGERICIN;Aids003767;Aids-003767;AZALOMYCIN M;NIGERICIN NA;POLYETHERIN A;Antibiotic M 2
CBNumber:
CB4331016
Molecular Formula:
C40H68O11
Molecular Weight:
724.96
MOL File:
28380-24-7.mol
Modify Date:
2023/5/18 11:31:15
Request For Quotation

NIGERICIN SODIUM SALT Properties

Melting point 183.5-185°
alpha D24 +36.2° (c = 0.842 in CHCl3)
Boiling point 779.9±60.0 °C(Predicted)
Density 1.19±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility chloroform: 10 mg/mL, clear, colorless
pka 4.39±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H319-H335-H301-H315
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes  T,Xi
Risk Statements  25-36/37/38
Safety Statements  26-36/37/39-45-36
RIDADR  UN 3462 6.1/PG 3
WGK Germany  3
RTECS  QT6840000
F  10
HazardClass  6.1(b)
PackingGroup  III
HS Code  29419090
Toxicity LD50 in mice (mg/kg): 10-15 i.p. (Shoji); also reported as 2.5 i.p. (Harned)

NIGERICIN SODIUM SALT Chemical Properties,Uses,Production

Uses

Nigericin is a polyether antibiotic produced by Streptomyces, notably S. hygroscopicus, isolated in the 1950s. Its complex structure was finally elucidated in 1968. Nigericin is an ionophore, possessing very high affinity for monovalent cations such as Na+ and K+. Nigericin disrupts membrane potential and Golgi apparatus in mitochondria. Although nigericin can be isolated as the free acid (under acidic conditions), like most ionophores it is extracted into organic solvents and is most conveniently isolated as a salt. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumour cell lines and some viruses, including HIV. Nigericin is the most common member of the polyether class which are common false positives in in vitro screening bioassays using crude microbial extracts. They are thus important standards for dereplication.

Definition

ChEBI: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.

NIGERICIN SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

NIGERICIN SODIUM SALT Suppliers

Global( 120)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21669 55 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29825 58 Inquiry
Fuxin Pharmaceutical +86-021-021-50872116 +8613122107989 China 10297 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
SIMAGCHEM CORP +86-13806087780 China 17367 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Baoji Guokang Healthchem co.,ltd +8615604608665 15604608665 CHINA 9427 58 Inquiry
Hebei Fengjia New Material Co., Ltd +86-0311-87836622 +86-17333973358 China 8086 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Henan Tianfu Chemical Co.,Ltd. 55
career henan chemical co 58
Fuxin Pharmaceutical 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 58
SIMAGCHEM CORP 58
TargetMol Chemicals Inc. 58
Baoji Guokang Healthchem co.,ltd 58
Hebei Fengjia New Material Co., Ltd 58
LEAP CHEM CO., LTD. 58

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(2R)-2-((3S)-6-{[2-((5S)-5-{(3S)-5-[(3S,5R,6R)-6-Hydroxy-6-(hydroxymethyl)-3,5-dimethylperhydro-2H-pyran-2-yl]-3-methyloxolan-2-yl}-5-methyloxolan-2-yl)(2S,4R,9R,10R)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methylperhydro-2H-pyran-2-yl)propanoic acid 28643-80-3 (Sodium salt) Aids003767 Aids-003767 Helix c AZALOMYCIN M HELIXIN C ANTIBIOTIC K178 ANTIBIOTIC K178 SODIUM SALT ANTIBIOTIC X-464 Polyetherin A, AzaloMycin M, Helixin C, K 178, X 464 Antibiotic M 2 x-464 NIGERICIN NIGERICIN NA NIGERICIN, NA SALT NIGERICIN, SODIUM SALT, STREPTOMYCES HYGROSCOPICUS POLYETHERIN A Nigericin from Streptomyces hygroscopicus Antibiotic K178 sodium salt, Azalomycin M nigericin sodium nigericin sodium from streptomyces*hygroscopicus nigericin sodium salt from streptomyces hygroscopicus NIGERICIN APPOX. 95% 28380-24-7 C40H68O11 BioChemical Antibiotics A to Z Antibiotics N-S Antibiotics antibiotic