ALPHA-HCH
- CAS No.
- 319-84-6
- Chemical Name:
- ALPHA-HCH
- Synonyms
- A-BHC;ALPHA-BHC;ALPHA-HEXACHLOROCYCLOHEXANE;Hexachlorcyclohexan;α-Hexachlorocyclohexane;r-1,c-2,t-3,c-4,t-5,t-6-hexachlorocyclohexane;a-HCH;ent9,232;ALPHA-HCH;ENT 9,232
- CBNumber:
- CB4345259
- Molecular Formula:
- C6H6Cl6
- Molecular Weight:
- 290.81
- MOL File:
- 319-84-6.mol
- Modify Date:
- 2024/3/14 15:18:26
| Melting point | 156-161 °C(lit.) |
|---|---|
| Boiling point | 373.64°C (rough estimate) |
| Density | 1.9 g/cm3 |
| vapor pressure | 173 at 25 °C (subcooled liquid vapor pressure calculated from GC retention time data, Hinckley etal., 1990) |
| refractive index | 1.60-1.626 (589.3 nm 20℃) |
| Flash point | 11 °C |
| storage temp. | APPROX 4°C |
| solubility | Soluble in ethanol, benzene, chloroform (Weast, 1986), cod liver oil, and octanol (Montgomery, 1993) |
| form | Solid |
| color | White |
| Water Solubility | 2mg/L(25 ºC) |
| BRN | 7073451 |
| Henry's Law Constant | 0.888 at 5 °C, 1.58 at 15 °C, 2.27 at 20 °C, 2.96 at 25 °C, 6.02 at 35 °C:in 3% NaCl solution: 1.48 at 5 °C, 2.76 at 15 °C, 5.23 at 25 °C, 7.20 at 35 °C (gas stripping-GC, Cetin et al., 2006) |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| EPA Substance Registry System | .alpha.-Hexachlorocyclohexane (319-84-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H312-H351-H410 |
| Precautionary statements | P202-P264-P273-P280-P301+P310-P302+P352+P312 |
| Hazard Codes | T,N,F |
| Risk Statements | 21-25-40-50/53-39/23/24/25-23/24/25-11-52/53 |
| Safety Statements | 22-36/37-45-60-61-16-7 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | GV3500000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LC50 (96-hour) for guppies >1.4 mg/L (Verschueren, 1983); acute oral LD50 for rats 177 mg/kg (RTECS, 1985). |
ALPHA-HCH Chemical Properties,Uses,Production
Chemical Properties
BHC is a white-to-brownish crystalline solid with a musty, phosgene-like odor.
Physical properties
Brownish to white monoclinic prisms, crystalline solid or powder with a phosgene-like odor (technical grade). An odor threshold concentration of 88 μg/kg was reported by Sigworth (1964).
Uses
α-1,2,3,4,5,6-Hexachlorocyclohexane is an organochloride which is one of the isomers of hexachlorocyclohexane and is an byproduct of insecticide Lindane (L465990).
General Description
White crystalline powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Halogenated aliphatic compounds, such as ALPHA-HCH, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.
Health Hazard
ACUTE/CHRONIC HAZARDS: Carcinogen. Toxic. Irritant. Hazardous decomposition product.
Fire Hazard
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Safety Profile
ConfEmed carcinogen with experimental carcinogenic, tumorigenic, and neoplastigenic data. Poison by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-. See also BENZENE HEXACHLORIDE and other benzenehexachloride entries.
Potential Exposure
The major commercial usage of BHC is based upon its insecticidal properties. α-BCH is used as an Agricultural chemical, pesticide, pharmaceutical, and veterinary drug. The 7-isomer has the highest acute toxic ity, but the other isomers are not without activity. It is gen erally advantageous to purify the 7-isomer from the less active isomers. The γ-isomer acts on the nervous system of insects, principally at the level of the nerve ganglia. As a result, lindane has been used against insects in a wide range of applications including treatment of animals, buildings, humans for ectoparasites, clothes; water for mosquitoes; living plants; seeds and soils. Some applications have been abandoned due to excessive residues, e.g., stored food stuffs. By voluntary action, the principal domestic producer of technical grade BHC requested cancellation of its BHC registrations on September 1, 1976. As of July 21, 1978, all registrants of pesticide products containing BHC voluntar ily canceled their registrations or switched their former BHC products to lindane formulations.
Environmental Fate
Biological. Clostridium sphenoides degraded α-BHC to δ-3,4,5,6-tetrachloro-1-cyclo hexane (Heritage and MacRae, 1977a). In four successive 7-day incubation periods, α-
BHC (5 and 10 mg/L) was recalcitrant to degradation in a settled domestic wastewater
inoculum (Tabak et al., 1981).
Soil. Under aerobic conditions, indigenous microbes in contaminated soil produced
pentachlorocyclohexane. However, under methanogenic conditions, α-BHC was converted
to chlorobenzene, 3,5-dichlorophenol and the tentatively identified compound 2,4
Photolytic. When an aqueous solution containing α-BHC was photooxidized by UV
light at 90–95°C, 25, 50 and 75% degraded to carbon dioxide after 4.2, 24.2 and 40.0
hours, respectively (Knoevenagel and Himmelreich, 1976). In basic, aqueous solution
Chemical/Physical. Emits very toxic chloride fumes when heated to decomposition
(Lewis, 1990). α-BHC will hydrolyze via trans-dehydrochlorination of the axial chlorines
resulting in the formation of hydrochloric acid and the intermediate 1,3,4,5,6-pentachlo rocyclo-hexene. The intermediate will undergo further hydrolysis resulting in the formation
of 1,2,3-trichlorobenzene, 1,2,4-trichlorobenzene and hydrochloric acid (Kollig, 1993).
Shipping
UN2761 Organochlorine pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods
Crystallise it from EtOH. Purify it also by zone melting. Possible CANCER AGENT, TOXIC. [: Beilstein 1 H 23, : Beilstein 5 I 8, many isomers : Beilstein 5 III 41, 5 IV 55.]
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Decomposes on contact with powdered iron, aluminum, zinc, and on contact with strong bases producing trichlorobenzene.
Waste Disposal
A process has been developed for the destructive pyrolysis of benzene hexachloride @ 400 500℃ with a catalyst mixture which contains 5 10% of either cupric chloride, ferric chloride; zinc chloride; or aluminum chloride on activated carbon.
ALPHA-HCH Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Inventichem | +918790275459 | Telangana, India | 155 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | China | 9003 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| LGC Standards | +44 (0)20 8943 8480 | United Kingdom | 6495 | 0 | Inquiry |
| Nanjing Shizhou Biology Technology Co.,Ltd | 18351873721 | China | 8298 | 58 | Inquiry |