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METHAPYRILENE HYDROCHLORIDE

CAS No.: 135-23-9

Chemical Name:: METHAPYRILENE HYDROCHLORIDE

Synonyms: dozar;barhist;coryzol;blueline;capathyn;histafed;methacon;Cohistine;somnicaps;methoxylene

CBNumber:: CB4405690

Molecular Formula:: C14H20ClN3S

Molecular Weight:: 297.85

MOL File:: 135-23-9.mol

Modify Date:: 2024/7/2 8:55:09

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METHAPYRILENE HYDROCHLORIDE Properties

Melting point	162°
storage temp.	room temp
solubility	DMF: 15 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
form	Solid
color	Off-white to yellow
Stability	Hygroscopic
EPA Substance Registry System	Methapyrilene hydrochloride (135-23-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301

Precautionary statements

P301+P310

Hazard Codes

Risk Statements

Safety Statements

22-36-45

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

UT1750000

HazardClass

6.1(b)

PackingGroup

III

Toxicity

LD50 oral in rat: 200mg/kg

NFPA 704

	0
2		0

METHAPYRILENE HYDROCHLORIDE Chemical Properties,Uses,Production

Uses

Methapyrilene is used as antihistaminic agent.

Definition

ChEBI: A hydrochloride that is the monohydrochloride salt of methapyrilene.

General Description

Methapyrilene hydrochloride,2-[[2-(dimethylamino)-ethyl]-2-thienylarnino]pyridine monohydrochloride (Histadyl) is available as the bitter-tasting, white crystalline powder that is soluble in water(1:0.5), in alcohol (1:5), and in chloroform (1:3). Its solutionshave a pH of about 5.5. It differs structurally from tripelennaminein having a 2-thiophene—methylene group in placeof the benzyl group. The thiophene ring is considered isostericwith the benzene ring, and the isosteres exhibit similaractivity. A study of the solid-state conformation of methapyrilenehydrochloride showed that the trans-conformation is preferredfor the two ethylenediamine nitrogen atoms. The Foodand Drug Administration declared methapyrilene a potentialcarcinogen in 1979, and all products containing it have beenrecalled.

Air & Water Reactions

Water soluble.

Reactivity Profile

METHAPYRILENE HYDROCHLORIDE is light sensitive. Solutions of METHAPYRILENE HYDROCHLORIDE in water, DMSO, 95% ethanol or acetone should be stable for 24 hours under normal lab conditions. . Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas.

Fire Hazard

Flash point data for METHAPYRILENE HYDROCHLORIDE are not available; however, METHAPYRILENE HYDROCHLORIDE is probably combustible.

METHAPYRILENE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Sodium amide 2-Aminopyridine Hydrochloric acid

Preparation Products

METHAPYRILENE HYDROCHLORIDE Suppliers

Global( 34)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Alfa Chemistry	+1-5166625404	United States	21317	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry
ShangHai Anpel Co, Ltd.	18501792038; 18501792038	China	9614	58	Inquiry
TargetMol Chemicals Inc.	15002134094	China	28118	58	Inquiry
Shanghai UCHEM Inc.	18939844854	China	5026	58	Inquiry
Guangzhou Younan Technology Co., Ltd	020-020-82000279 18988968278	China	2493	58	Inquiry
Cayman Chemical Company	(800) 364-9897	United States	6618	81	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Alfa Chemistry	58
TargetMol Chemicals Inc.	58
LEAPCHEM CO., LTD.	58
ShangHai Anpel Co, Ltd.	58
TargetMol Chemicals Inc.	58
Shanghai UCHEM Inc.	58
Guangzhou Younan Technology Co., Ltd	58
Cayman Chemical Company	81

135-23-9(METHAPYRILENE HYDROCHLORIDE)Related Search:

METHAPYRILENE HYDROCHLORIDE SOLUTION 100UG/ML IN METHANOL 5ML METHAPYRILENE HYDROCHLORIDE SOLUTION 100UG/ML IN METHANOL 1ML METHAPYRILENE HYDROCHLORIDE SOLUTION 100UG/ML IN METHANOL 5X1ML 2-Aminopyridinehydrochloride N-2-Pyridinyl-1,2-ethanediamine

N-Ethyl-2-thienylamine N-METHYL-N-PYRIDIN-2-YLETHANE-1,2-DIAMINE METHAPYRILENE HYDROCHLORIDE Chloropyrilene 2-Thiophenemethylamine

2-(ETHYLMETHYLAMINO)PYRIDINE N-Methyl-(2-thienylmethyl)amine 2-DIETHYLAMINOPYRIDINE 2-(DIMETHYLAMINOMETHYL)THIOPHENE 2-Dimethylaminopyridine

METHAPYRILENE

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N,N-DIMETHYL-N'-[2-PYRIDINYL]-N'-[2-THIENYLMETHYL]-1,2-ETHANEDIAMINE HYDROCHLORIDE 2-((2-(dimethylamino)ethyl)-2-thenyl-amino)pyridinehydrochloride 2-((2-(dimethylamino)ethyl)-2-thenylamino)-pyridinmonohydrochloride METHAPYRILENE HCL METHAPYRILENE HYDROCHLORIDE LABOTEST-BB LT00772145 2-dimethylaminoethyl-(2-pyridyl)-(2-thenyl)amine hydrochloride N',N'-dimethyl-N-pyridin-2-yl-N-(thiophen-2-ylmethyl)ethane-1,2-diamine hydrochloride Cohistine N,N-DiMethyl-N'-2-pyridinyl-N'-(2-thienylMethyl)-1,2-ethanediaMine MonoHydrochloride N1,N1-DiMethyl-N2-2-pyridinyl-N2-(2-thienylMethyl)-1,2-ethanediaMine Hydrochloride 2-ethanediamine,n,n-dimethyl-n’-2-pyridinyl-n’-(2-thienylmethyl)-monohyd 2-ethanediamine,n,n-dimethyl-n’-2-pyridinyl-n’-(2-thienylmethyl)-monohydro barhist blueline capathyn compound01013 coryzol dozar histafed methacon methoxylene n,n-dimethyl-n’-(2-pyridyl)-n’-(2-thenyl)ethylenediaminehydrochloride n,n-dimethyl-n’-(2-pyridyl)-n’-(2-thenyl)-ethylenediaminhydrochloride n,n-dimethyl-n’-(2-thenyl)-n’-(2-pyridyl-ethylene-diaminehydrochloride) semikonhydrochloride somnicaps tem-histine thenylenehydrochloride thenylpyraminehydrochloride w-53hydrochloride METHAPYRILENE HCL, 1000MG,NEAT Zavegepant Impurity 10 135-23-9 C14H19N3SHCl C14H19N3SClH Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds Alpha Sort M MAlphabetic META - METH Volatiles/ Semivolatiles