METHAPYRILENE | 91-80-5

METHAPYRILENE Properties

Melting point	25°C
Boiling point	bp0.45 125-135°; bp3 173-175°
Density	1.1388 (rough estimate)
refractive index	nD25 1.5842 (also reported as 1.5835)
storage temp.	Refrigerator, under inert atmosphere
solubility	DMSO (Sparingly), Methanol (Slightly)
form	Oil
pka	pKa 3.02 ± 0.05;8.24± 0.11(H2O,t undefined,I=0.30(NaCl)) (Uncertain)
color	Colourless to Light Yellow
Water Solubility	601.2mg/L(30 ºC)
Stability	Stable. Incompatible with strong oxidizing agents.
EPA Substance Registry System	Methapyrilene (91-80-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P264-P270-P301+P310-P321-P330-P405-P501
RIDADR	1851
HazardClass	6.1(b)
PackingGroup	III
Toxicity	LD50 in mice, guinea pigs (mg/kg): 182.2 ±12.8, 374.9 ±34.5 orally; in mice (mg/kg): 19.85 ±0.69 i.v. (Lee)

METHAPYRILENE Chemical Properties,Uses,Production

Chemical Properties

colourless liquid

Uses

Methapyrilene is an intermediate in the synthesis of Methapyrilene Hydrochloride (M259970). Methapyrilene is used as antihistaminic agent.

Definition

ChEBI: A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group.

World Health Organization (WHO)

Methapyrilene, an antihistamine with moderate sedative activity, was introduced in 1947 for the treatment of various allergic conditions and was subsequently incorporated in many over-the-counter sleeping aids. In the early 1970s it was identified as a carcinogen in rats and, although there was no direct evidence that it constitutes a health hazard to man, it was withdrawn in many countries. (Reference: (WHODI) WHO Drug Information, 2, 4, 1979)

General Description

Clear colorless liquid.

Reactivity Profile

An amine, organosulfide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

ACUTE/CHRONIC HAZARDS: METHAPYRILENE is highly toxic by ingestion.

Fire Hazard

Flash point data for METHAPYRILENE are not available, but METHAPYRILENE is probably combustible.

Metabolic pathway

When methaphenilene is incubated with rat liver microsomes, it is metabolized via N-oxide formation and N-dealkylation which includes removal of the dimethylamino moiety, the thiophenylmethyl moiety of methaphenilene, and the benzyl moiety of pyribenzamine.

METHAPYRILENE Preparation Products And Raw materials

Raw materials

Hydrochloric acid Sodium amide 2-Aminopyridine N-(2-thienylmethyl)pyridin-2-amine 2-Bromopyridine

2-(Chloromethyl)thiophene 2-Chloroethyldimethylamine

chevron_left

1of2

chevron_right

Preparation Products

2-(2-pyridylamino)ethyldimethylamine

METHAPYRILENE Suppliers

Global( 17)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	China	9003	58	Inquiry
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd	15229059051	China	9971	58	Inquiry
ShangHai Anpel Co, Ltd.	18501792038; 18501792038	China	9614	58	Inquiry
Shanghai Aitixi Biotechnology Co., Ltd	18721763493 18721763493	China	970	58	Inquiry
Guangzhou Younan Technology Co., Ltd	020-020-82000279 18988968278	China	2493	58	Inquiry
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	China	18018	56	Inquiry
TCI (Shanghai) Chemical Trading Co., Ltd.	021-021-61109150	China	31163	58	Inquiry
TargetMol Chemicals Inc.	4008200310	China	24017	58	Inquiry

Supplier	Advantage
Pharmaffiliates Analytics and Synthetics P. Ltd	58
TargetMol Chemicals Inc.	58
Shaanxi Didu New Materials Co. Ltd	58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd	58
ShangHai Anpel Co, Ltd.	58
Shanghai Aitixi Biotechnology Co., Ltd	58
Guangzhou Younan Technology Co., Ltd	58
ChemStrong Scientific Co.,Ltd	56
TCI (Shanghai) Chemical Trading Co., Ltd.	58
TargetMol Chemicals Inc.	58

91-80-5(METHAPYRILENE)Related Search:

NORTRIPTYLINE HYDROCHLORIDE Tripelennamine METHAPYRILENE METHAPYRILENE FUMARATE METHAPYRILENE HYDROCHLORIDE

Chloropyrilene PYRIDINES MIXTURE

chevron_left

1of2

chevron_right

N-(2-Pyridyl)-N-(2-thienylmethyl)-N',N'-dimethylethylenediamine 2-dimethylaminoethyl-(2-pyridyl)-(2-thienylmethyl)amine N',N'-dimethyl-N-pyridin-2-yl-N-(thiophen-2-ylmethyl)ethane-1,2-diamine 1,2-Ethanediamine, N,N-dimethyl-N'-2-pyridinyl-N'-(2-thienylmethyl)- 2-((2-(dimethylamino)ethyl)-2-thenylamino)-pyridin 2-((2-(dimethylamino)ethyl)-2-thenylamino)pyridine 2-((2-(dimethylamino)ethyl)-2-thienylamino)pyridine 2-[(2-dimethyl-aminoethyl)-2-thenylamino]pyridine 2-[[2-(Dimethylamino)ethyl]-2-thenylamino]pyridine A 3322 a3322 AH-42 Histadyl histadylbase histase Lulamin Lullamin Metapyrilene Methaphenilene methapyrilene methapyrilene,(base) Methapyriline methylpyrilene N-(alpha-Pyridyl)-N-(alpha-thenyl)-N',N'-dimethylethylenediamine n-(alpha-pyridyl)-n-(alpha-thenyl)-n’,n’-dimethylethylenediamine n,n-dimethyl-n’-2-pyridinyl-n’-(2-thienylmethyl)-1,2-ethanediamide n,n-dimethyl-n’-2-pyridinyl-n’-(2-thienylmethyl)-1,2-ethanediamine n,n-dimethyl-n’-2-pyridinyl-n’-(2-thienylmethyl)-2-ethanediamine n,n-dimethyl-n’-pyrid-2-yl-n’-2-thenylethylenediamine N,N-Dimethyl-N'-2-pyridinyl-N'-(2-thienylmethyl)-1,2-ethanediamine N,N-Dimethyl-N'-pyrid-2-yl-N'-2-thenylethylenediamine nci-c09018 NCI-C55550 Paradormalene pyrahistine Pyrathyn Pyridine, 2-[[2-(dimethylamino)ethyl]-2-thenylamino]- Pyrinistab Pyrinistol Rcra waste number U155 rcrawastenumberu155 Rest-On Restryl Semikon Sleepwell Tenalin tenalinbase Thenylene thenylenebase Thenylpyramine Thionylan N,N-dimethyl-N-2-pyridyl-N-2-thenylethylenediamine Methapyrilene@100 μg/mL in Dichloromethane Methapyrilene@1000 μg/mL in Dichloromethane 1,2-Ethanediamine, N1,N1-dimethyl-N2-2-pyridinyl-N2-(2-thienylmethyl)- Pyrahistidin 91-80-5 EDARBI