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Tripelennamine

CAS No.: 91-81-6

Chemical Name:: Tripelennamine

Synonyms: Tonaril;Benzoxale;Resistamine;Tripelenamine;PYRIBENZAMINE;Tripelennamine;Tripelennamine USP/EP/BP;N'-benzyl-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine;1,2-Ethanediamine, N,N-dimethyl-N-(phenylmethyl)-N-2-pyridinyl-;N,N-Dimethyl-N'-(phenylmethyl)-N'-(2-pyridinyl)-1,2-ethanediamine

CBNumber:: CB5875795

Molecular Formula:: C16H21N3

Molecular Weight:: 255.36

MOL File:: 91-81-6.mol

MSDS File:: SDS

Modify Date:: 2023/5/4 17:34:43

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Tripelennamine Properties

Melting point	25°C
Boiling point	bp0.1 138-142°; bp1.7 185-190°; bp20 193-205°
Density	1.0683 (rough estimate)
refractive index	nD25 1.5759-1.5765
pka	pKa 3.90±0.08(H2O t undefined I = 0.30 (NaCl)) (Uncertain);8.68±0.06(H2O t undefined I = 0.30 (NaCl)) (Uncertain)
Water Solubility	587.3mg/L(30 ºC)
Stability	Stable. Incompatible with strong oxidizing agents.
EPA Substance Registry System	Tripelennamine (91-81-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08,GHS09,GHS05,GHS06
Signal word	Danger
Hazard statements	H411-H373-H331-H302-H318-H361
Precautionary statements	P280-P305+P351+P338-P310-P260-P314-P501-P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501
Toxicity	LD50 oral in mouse: 152mg/kg

Tripelennamine Chemical Properties,Uses,Production

Chemical Properties

White, bitter, crystalline powder. Solutions are acid to litmus.Soluble in water and alcohol; very slightly soluble in ether; practically insoluble in chloroform and benzene; 1% solution in water has a pH of 4.3.

Uses

This drug lessens the allergic response of the organism caused by histamine. Tripelennamine is used for allergic symptoms, rhinitis, conjunctivitis, and for allergic and anaphylactic reactions. Synonyms of this drug are pelanin and pyribenzamine.

Reactivity Profile

Tripelennamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

SYMPTOMS: Symptoms of exposure to Tripelennamine may include euphoria, aplastic anemia, excitement, hallucinations, ataxia, incoordination, athetosis, convulsions, postictal depression, dry mouth, fixed dilated pupils, flushing of the face, fever, central nervous system depression, drowsiness and coma.

Fire Hazard

Flash point data for Tripelennamine are not available. Tripelennamine is probably combustible.

Safety Profile

Poison by ingestion and intraperitoneal routes. Human mutation data reported. Has been implicated in aplastic anemia. Used as an antdustasnine. Addicts have added it to paregoric to make "blue velvet," whtch can cause euphoria by injection. When heated to decomposition it emits toxic fumes of NOx.

Metabolic pathway

When pyribenzamine is incubated with rat liver microsomes, it is metabolized via N-oxide formation and N-dealkylation which includes removal of the dimethylamino moiety, the thiophenylmethyl moiety of methaphenilene, and the benzyl moiety of pyribenzamine.

Tripelennamine Preparation Products And Raw materials

Raw materials

Sodium amide Benzaldehyde

Preparation Products

Tripelennamine Suppliers

Global( 18)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-15319487004	China	2132	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	China	7726	58	Inquiry
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	China	52861	58	Inquiry
Nanjing Xinmeihe Pharmaceutical Co., Ltd.	025-57672321 13739186949	China	236	58	Inquiry
ShangHai Anpel Co, Ltd.	18501792038; 18501792038	China	9614	58	Inquiry
SHANGHAI ZZBIO CO., LTD.	15102117276 19921389125	China	12064	58	Inquiry
TargetMol Chemicals Inc.	4008200310	China	24647	58	Inquiry
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd	15229059051	China	9978	58	Inquiry
Shenzhen Yaoyuan R&D Center Co., Ltd	13421666688 13421666688	China	411	58	Inquiry

Supplier	Advantage
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Nanjing Xinmeihe Pharmaceutical Co., Ltd.	58
ShangHai Anpel Co, Ltd.	58
SHANGHAI ZZBIO CO., LTD.	58
TargetMol Chemicals Inc.	58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd	58
Shenzhen Yaoyuan R&D Center Co., Ltd	58

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1,2-Ethanediamine, N,N-dimethyl-N-(phenylmethyl)-N-2-pyridinyl- PYRIBENZAMINE Benzoxale N,N-Dimethyl-N'-(phenylmethyl)-N'-(2-pyridinyl)-1,2-ethanediamine Resistamine Tonaril Tripelenamine N'-benzyl-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine Tripelennamine 1,2-Ethanediamine, N1,N1-dimethyl-N2-(phenylmethyl)-N2-2-pyridinyl- Tripelennamine USP/EP/BP Tripelennamine N'-benzyl-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine 91-81-6