PYRILAMINE MALEATE

PYRILAMINE MALEATE Properties

Melting point	101-103°C
storage temp.	2-8°C
solubility	Very soluble in water, freely soluble in ethanol (96 per cent).
form	Solid
color	White
Water Solubility	Soluble in water at 100mg/ml
λmax	310nm(EtOH)(lit.)
Merck	14,7984
Stability	Stability Combustible. Incompatible with strong oxidizing agents.
LogP	2.751 (est)
CAS DataBase Reference	59-33-6(CAS DataBase Reference)
EPA Substance Registry System	Pyrilamine maleate (59-33-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

Hazard Codes

Xn

Risk Statements

22-36/37/38

Safety Statements

26-36/37

WGK Germany

3

RTECS

UT1225000

TSCA

Yes

HS Code

2933399090

Toxicity

LD50 orally in mice: 338 mg/kg (Hunziker)

NFPA 704

	0
2		0

PYRILAMINE MALEATE price More Price(6)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	P5514	Pyrilamine maleate salt	59-33-6	5G	₹7209.45	2022-06-14	Buy
Sigma-Aldrich(India)	PHR1340	Pyrilamine maleate Pharmaceutical Secondary Standard; Certified Reference Material	59-33-6	500MG	₹8919.8	2022-06-14	Buy
Sigma-Aldrich(India)	P5514	Pyrilamine maleate salt	59-33-6	25G	₹10792.53	2022-06-14	Buy
Sigma-Aldrich(India)	P5514	Pyrilamine maleate salt	59-33-6	100G	₹28762.03	2022-06-14	Buy
TCI Chemicals (India)	P2369	Pyrilamine Maleate	59-33-6	5G	₹2300	2022-05-26	Buy

Product number	Packaging	Price	Buy
P5514	5G	₹7209.45	Buy
PHR1340	500MG	₹8919.8	Buy
P5514	25G	₹10792.53	Buy
P5514	100G	₹28762.03	Buy
P2369	5G	₹2300	Buy

PYRILAMINE MALEATE Chemical Properties,Uses,Production

Description

Mepyramine is a first generation antihistamine that acts as an inverse agonist at the histamine H₁ receptor. It is reported to bind with high affinity to a G_q/11 protein-coupled form of the receptor and to promote a G protein-coupled inactive state of the H₁ receptor that interferes with the G_q/11-mediated signaling of the endogenously expressed receptor, as well as to reduce G protein availability for other non-related receptors associated with this signaling pathway. Mepyramine has been shown to inhibit histamine-induced inositol phosphate production with a log EC₅₀ value of -7.94.

Chemical Properties

solid

Uses

Pyrilamine maleate Selective inverse agonist for the H-1 histamine receptor. Pyrilamine Maleate is commonly utilized as a radioligand ([3H]Mepyramine) binding assay for the H1 receptor. And also used to exhibit blocking ability of KCNQ/M channels which is potentially related to an adverse effect seen in excess intake of antihistamines.

General Description

White crystals or powder. Melting point 100-101°C. Bitter saline taste. An antihistaminic medicine.

Air & Water Reactions

Water soluble.

Reactivity Profile

PYRILAMINE MALEATE is an acidic salt of an amine. Usually does not react as either oxidizing agents or reducing agents but such behavior is not impossible. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

SYMPTOMS: Symptoms of exposure to PYRILAMINE MALEATE may include drowsiness, potentiation of the sedative effect of barbituates, fatigues, vertigo, incoordination, tremor, muscle weakness, dryness of the mouth and throat, tinnitus, pupillary dilation, blurred vision, urinary retention, impotence, epigastric and intestinal pain, anorexia, nausea, vomiting, diarrhea, excitation, euphoria, insomnia, nervousness, palpitation, tachycardia, hypotension, hypersensitivity reactions, respiratory depression, coma and delirium.

Fire Hazard

Flash point data for PYRILAMINE MALEATE are not available, however PYRILAMINE MALEATE is probably combustible.

Biological Activity

Selective inverse agonist for the H 1 receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC50 = -7.94) and intracellular calcium mobilization. Sequesters G q/11 protein, reducing its availability for other receptors associated with the same signaling pathway.

Safety Profile

A human poison by ingestion. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. An antihistamine. When heated to decomposition it emits toxic fumes of NOx.

PYRILAMINE MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

PYRILAMINE MALEATE Suppliers

Global( 195)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Malladi Drugs AND Pharmaceuticals Limited	+91-9004653310 +91-9003056437	Tamil Nadu, India	69	58	Inquiry
Venkatasai Life Sciences	+91-9908134868 +91-8008303069	Hyderabad, India	186	58	Inquiry
Supriya Lifescience Ltd	+91-9820804279 +91-9821266261	Maharashtra, India	27	58	Inquiry
Ralington Pharma	+91-7948911722 +91-9687771722	Gujarat, India	1350	58	Inquiry
Keshava Organics Pvt Ltd	91-22-29271436	Maharashtra, India	7	58	Inquiry
Heer Pharma Pvt Ltd	+91-9820051881 +91-9820051881	Maharashtra, India	102	58	Inquiry
OCEAN TRADING CORPORATION	+91(22) 24921669	New Delhi, India	6211	58	Inquiry
Medilink Pharmachem	+91 (79) 3007-0133	New Delhi, India	424	50	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry

Supplier	Advantage
Malladi Drugs AND Pharmaceuticals Limited	58
Venkatasai Life Sciences	58
Supriya Lifescience Ltd	58
Ralington Pharma	58
Keshava Organics Pvt Ltd	58
Heer Pharma Pvt Ltd	58
OCEAN TRADING CORPORATION	58
Medilink Pharmachem	50
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58

PYRILAMINE MALEATE Spectrum

PYRILAMINE MALEATE(59-33-6)¹HNMR

59-33-6(PYRILAMINE MALEATE)Related Search:

FORMANILIDE 4-Aminodiphenylamine 2-Benzylaminopyridine 2-(4-Methoxybenzylamino)pyridine PYRILAMINE

2-DIETHYLAMINOPYRIDINE Tripelennamine N,N'-Dimethyl-1,2-ethanediamine (METHOXYMETHYL)DIPHENYLPHOSPHINE OXIDE N,N-Dimethylethylenediamine

PYRILAMINE MALEATE Ammonium hydrogen maleate N-METHYL-N-PYRIDIN-2-YLETHANE-1,2-DIAMINE N-2-Pyridinyl-1,2-ethanediamine N'-(5-AMINOPENTYL)-N-(4-METHOXYBENZYL)-N'-METHYL-N-2-PYRIDINYL-1,2-ETHANEDIAMINE, DIMALEATE SALT

2-(ETHYLMETHYLAMINO)PYRIDINE N-(4-Methoxybenzyl)-N-2-pyridinyl-1,2-ethanediamine [[(2-aminoethyl)amino]methyl]phenol

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MEPYRAMINE MALEATE MEPYRAMINE MALEATE SALT n-dimethylaminoethyl-n-p-methoxy-alpha-aminopyridinemaleate neo-anterganmeleate n-p-methoxybenzyl-n’-n’-dimethyl-n-alpha-pyridylethylenediaminemaleate paramal paraminylmaleate pymafed pyramaleate pyranilaminemaleate pyraninyl pyrilaminemaleatecrystalline renstamin stangenmaleate statominmaleate thylogenmaleate PYRILAMINE MALEATE METHANOL SOLUTION 2-((2-Dimethylaminoethyl)-(p-methoxybenzyl)amino)p(mepyraminemaleate) 2-[(2-DIMETHYLAMINOETHYL)(P-METHOXYBENZYL)AMINO]PYRIDINE MALEATE PYRILAMINE MALEATE PYRILAMINE MALEATE SALT PYRANISAMINE MALEATE N-(P-METHOXYBENZYL)-N',N'-DIMETHYL-N-2-PYRIDYLETHYLENEDIAMINE MALEATE N-[4-METHOXY-PHENYL]METHYL-N',N'-DIMETHYL-N[2-PYRIDINYL]-1,2-ETHANEDIAMINE MALEATE SALT antihist diaminidemaleate minihist n-((4-methoxyphenyl)methyl)-n,n’-dimethyl-n-2-pyridinyl-2-ethanediamine n,n-dimethyl-n’-(4-methoxybenzyl)-n’-(2-pyridyl)ethylenediaminemaleate (z)-2-butenedioat 1,2-Ethanediamine,N-[(4-methoxyphenyl)methyl]-N’,N’-dimethyl-N-2-pyridinyl-,(Z)-2-butenedioate(1:1) 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)pyridinebimaleate 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridinmaleate(1:1) 2786r.p.maleate 2-ethanediamine,n-[(4-methoxyphenyl)methyl]-n’,n’-dimethyl-n-2-pyridinyl-( anisopyradamine anthisanmaleate 1,2-Ethanediamine, N-(4-methoxyphenyl)methyl-N,N-dimethyl-N-2-pyridinyl-, (2Z)-2-butenedioate (1:1) PYRILAMINEMALEATE,USP Histatex Pyrilaminmaleat 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridin maleate 2-[(2-DIMETHYLAMINOETHYL)(P-METHOXYBENZYL)AMINO]PYRIDINE MALEATE USP PYRILAMINE MALEATE USP/NF Mepyramine maleate salt, N-(4-Methoxyphenyl)methyl-Nμ,Nμ-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt Pyrilamine Maleate (200 mg) BiMaleate N-[(4-Methoxyphenyl)Methyl]-N',N'-diMethyl-N-2-pyridinyl- 1,2-ethanediaMine (2Z)-2-Butenedioate N1-[(4-Methoxyphenyl)Methyl]-N2,N2-diMethyl-N1-2-pyridinyl-1,2-ethanediaMine (2Z)-2-Butenedioate N1-(4-Methoxybenzyl)-N2,N2-diMethyl-N1-(pyridin-2-yl)ethane-1,2-diaMine fuMarate Mepyramine maleate CRS N-(4-Methoxybenzyl)-N′,N′-dimethyl-N-(pyridin-2- yl)ethane-1,2-diamine (Z)-butenedioate N1-(4-Methoxybenzyl)-N2,N2-dimethyl-N1-(pyridin-2-yl)ethane-1,2-diamine maleate PyrilamineMaleateSal N-(4-Methoxyphenyl)methyl-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine Maleate PYRILAMINE MALEATE USP/EP/BP Mepyramine maleateQ: What is Mepyramine maleate Q: What is the CAS Number of Mepyramine maleate Q: What is the storage condition of Mepyramine maleate Q: What are the applications of Mepyramine maleate Pyrilamine Maleate (1588004)