METHAPYRILENE manufacturers and suppliers in india

METHAPYRILENE

CAS:: 91-80-5

MF:: C14H19N3S

MW:: 261.38576

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Properties

Melting point:: 25°C

Boiling point:: bp0.45 125-135°; bp3 173-175°

Density: 1.1388 (rough estimate)

refractive index: nD25 1.5842 (also reported as 1.5835)

storage temp.: Refrigerator, under inert atmosphere

solubility: DMSO (Sparingly), Methanol (Slightly)

form: Oil

pka: pKa 3.02 ± 0.05;8.24± 0.11(H2O,t undefined,I=0.30(NaCl)) (Uncertain)

color: Colourless to Light Yellow

Water Solubility: 601.2mg/L(30 ºC)

Stability:: Stable. Incompatible with strong oxidizing agents.

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301

Precautionary statements: P264-P270-P301+P310-P321-P330-P405-P501

RIDADR: 1851

HazardClass: 6.1(b)

PackingGroup: III

Toxicity: LD50 in mice, guinea pigs (mg/kg): 182.2 ±12.8, 374.9 ±34.5 orally; in mice (mg/kg): 19.85 ±0.69 i.v. (Lee)

Use

Methapyrilene, an antihistamine with moderate sedative activity, was introduced in 1947 for the treatment of various allergic conditions and was subsequently incorporated in many over-the-counter sleeping aids. In the early 1970s it was identified as a carcinogen in rats and, although there was no direct evidence that it constitutes a health hazard to man, it was withdrawn in many countries. (Reference: (WHODI) WHO Drug Information, 2, 4, 1979)