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PENTAGASTRIN

PENTAGASTRIN Structure
CAS No.
5534-95-2
Chemical Name:
PENTAGASTRIN
Synonyms
GRP;ay6608;ici50123;petavlon;peptavlon;petogasrin;lanineamide;PENTAGASTRIN;Pehtagastrin;gastrodiagnost
CBNumber:
CB4412263
Molecular Formula:
C37H49N7O9S
Molecular Weight:
767.9
MOL File:
5534-95-2.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:09
Request For Quotation

PENTAGASTRIN Properties

Melting point 229-230° (dec)
alpha D22 -28.8 ±0.5° (DMF)
Boiling point 1196.6±65.0 °C(Predicted)
Density 1.303±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Practically insoluble in water; soluble in 5M ammonia and in dimethylformamide; slightly soluble in ethanol (96%).
form powder
pka 4.19±0.10(Predicted)
color White to off-white
Sequence N-t-Boc-β-Ala-Trp-Met-Asp-Phe-NH2
InChIKey NEYNJQRKHLUJRU-DZUOILHNSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332
Hazard Codes  T
Risk Statements  61-36/38-20/21
Safety Statements  53-45-36/37/39-22
WGK Germany  1
RTECS  AY2970000
NFPA 704
0
3 0

PENTAGASTRIN price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) B1636 Pentagastrin ≥95% (HPLC), powder 5534-95-2 25MG ₹20437.6 2022-06-14 Buy
Sigma-Aldrich(India) B1636 Pentagastrin ≥95% (HPLC), powder 5534-95-2 100MG ₹65144.85 2022-06-14 Buy
Product number Packaging Price Buy
B1636 25MG ₹20437.6 Buy
B1636 100MG ₹65144.85 Buy

PENTAGASTRIN Chemical Properties,Uses,Production

Description

Pentagastrin is a synthetic polypeptide and cholecystokinin-2 (CCK2) receptor agonist. It binds selectively to CCK2 receptors in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively). Pentagastrin increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively). It also increases histidine decarboxylase activity in mucous- and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM). Pentagastrin induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM). It increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively). Formulations containing pentagastrin have previously been used as a diagnostic aid to evaluate gastric acid secretory function.

Chemical Properties

A white or almost white powder.

Uses

Pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.

General Description

Pentagastrin (Peptavlon), a physiologicalgastric acid secretagogue, is the synthetic pentapeptide derivative:N-t-butyloxycarbonyl-β-alanyl-L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalanyl amide. It contains theCOOH-terminal tetrapeptide amide (H·Try·Met· Asp·Phe·NH2), which is considered to be the active center ofthe natural gastrins. Accordingly, pentagastrin appears tohave the physiological and pharmacological properties ofthe gastrins, including stimulation of gastric secretion,pepsin secretion, gastric motility, pancreatic secretion ofwater and bicarbonate, pancreatic enzyme secretion, biliaryflow and bicarbonate output, intrinsic factor secretion, andcontraction of the gallbladder.
Pentagastrin is indicated as a diagnostic agent to evaluategastric acid secretory function, and it is useful in testing foranacidity in patients with suspected pernicious anemia, atrophicgastritis or gastric carcinoma, hypersecretion in suspectedduodenal ulcer or postoperative stomal ulcers, andZollinger-Ellison tumor.

PENTAGASTRIN Preparation Products And Raw materials

Raw materials

β-Alanine N-[(tert-Butoxy)carbonyl]-D-tryptophan Protective agent Propionamide L-ASPARTIC ACID

Preparation Products

PENTAGASTRIN Suppliers

Global( 168)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd +86-0533-2185556 +8617865335152 China 10978 58 Inquiry
Shanghai Getian Industrial Co., LTD +86-15373193816 +86-15373193816 China 269 58 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9337 55 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29898 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. 0551-65418671 China 34571 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-029-89586680 +86-18192503167 China 9030 58 Inquiry
Wuhan Fortuna Chemical Co., Ltd +86-027-59207850 China 5992 58 Inquiry
Baoji Guokang Bio-Technology Co., Ltd. 0917-3909592 13892490616 China 9322 58 Inquiry
BOC Sciences 16314854226; +16314854226 United States 19743 58 Inquiry
Supplier Advantage
Zibo Hangyu Biotechnology Development Co., Ltd 58
Shanghai Getian Industrial Co., LTD 58
Hangzhou FandaChem Co.,Ltd. 55
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
Hefei TNJ Chemical Industry Co.,Ltd. 58
Shaanxi Dideu Medichem Co. Ltd 58
Wuhan Fortuna Chemical Co., Ltd 58
Baoji Guokang Bio-Technology Co., Ltd. 58
BOC Sciences 58

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T-BOC-BETA-ALA-TRP-MET-ASP-PHE-NH2 aspartyl]-l-phenylalaninamide ay6608 boc-beta-ala-try-met-asp-phe(nh2) gastrodiagnost ici50123 lanineamide l-methionyl-l-alpha-aspartyl- l-n-tert-butyleste n-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-l-tryptophyl-l-phenylalaninamid petogasrin -tert-butylester ylpropionamido]-4-(methylthio)butyramido]succinamicacidn-tert-butylester n-t-boc-β-ala-trp-met-asp-phe amide N-T-boc-B-ala-trp-met-asp-phe amide PENTAGASTRIN (ICI 50123) SYNTHETIC >99% BOC-β-Ala-Trp-Met-Asp-Phe-NH2 N-(1,1-Dimethylethoxy)carbonyl-βAla-L-Trp-L-Met-L-Asp-L-Phe-NH2 N-Boc-βAla-L-Trp-L-Met-L-Asp-L-Phe-NH2 AY 6608, ICI 50123, NSC 367746, Boc-(b-Ala13)-Gastrin (13-17), Boc-b-Ala-CCK-4 Boc-b-Ala-Trp-Met-Asp-Phe-NH2 n-(alpha-carbamoylphenethyl)-3-[2-[2-[3-(carboxyamino)propionamido]-3-indol-3- n-[n-[n-[n-(n-tert-butoxycarbonyl-beta-alanyl)-l-tryptophanyl]-l-methionyl]-l- n-carboxy-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartylphenyl-alaninamid n-carboxy-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartylphenyl-l-alaninamiden n-t-butyloxycarbonyl-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartyl-l-phenyla peptavlon petavlon Boc-(β-Ala13)-Gastrin (13-17) GRP GASTRIN RELEASING PEPTIDE BOC-BETA-ALA-TRP-MET-ASP-PHE-NH2 PENTAGASTRIN N-T-BOC-BETA-ALA-TRP-MET-ASP-PHE AMIDE Acetyl-L-glutamic acid &gamma Z-N-methyl-L-glutamic acid &gamma N-(Benzyloxycarbonyl)-L-glutamic Acid &alpha Fmoc-L-alpha-aminoadipic acid &delta Fmoc-N-methyl-L-glutamic acid &gamma Methotrexate &alpha 3-7-Cholecystokinin-7(swine), 3-[N-[(1,1-dimethylethoxy)carbonyl]-b-alanine]- (9CI) L-Glutamic Acid &alpha DL-Glutamic acid &gamma N-tert-Butyloxycarbonyl-L-aspartic Acid &beta Pentagastrin, ≥95%(HPLC) Z-L-beta-Glutamic acid &gamma Fmoc-L-aspartic Acid &beta Pehtagastrin L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl- PENTAGASTRIN USP/EP/BP Boc-(β-Ala13)-Gastrin (13-17) 5534-95-2 C37H49N7O9S C37H50N7O9S Gastrointestinal Products Cholecystokinins Peptides Amino Acids and Peptides