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Terlipressin acetate

CAS No.: 14636-12-5

Chemical Name:: Terlipressin acetate

Synonyms: TERLIPRESSIN;Terlipressin for NMR identification;H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2;Glypressin;Glycylpressin;Terilipressin;TerlipressinuM;Terlipressin CRS;Terlipressin(net);Terlipressin, >99%

CBNumber:: CB4266213

Molecular Formula:: C52H74N16O15S2

Molecular Weight:: 1227.37

MOL File:: 14636-12-5.mol

Modify Date:: 2024/4/16 18:29:06

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Terlipressin acetate Properties

Melting point	>170°C (dec.)
Boiling point	1824.0±65.0 °C(Predicted)
Density	1.46±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	9.90±0.15(Predicted)
color	White
Sequence	Gly-Gly-Gly-c[Cys-Tyr-Phe-Gln-Asn-Cys]-Pro-Lys-Gly-NH2，(Disulfide bridge: Cys-Cys)
InChIKey	BENFXAYNYRLAIU-ITQMCZIINA-N
CAS DataBase Reference	14636-12-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H332
Precautionary statements	P261-P271-P304+P340-P312
HS Code	3504009000

Terlipressin acetate Chemical Properties,Uses,Production

Description

Terlipressin acetate is a novel synthetic long-acting vasopressin preparation. It is a kind of prodrug, which is inactive by itself. After the action of aminopeptidase in the body, after removing the three glycyl residues at its N-terminus, it slowly "releases" the active lysine vasopressin. Therefore, terlipressin acts as a reservoir that releases lysine vasopressin at a steady rate.

Chemical Properties

N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin (Terlipressin acetate) is White Solid

Uses

Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It is used norepinephrine-resistant septic shock and hepatorenal syndrome. It is also used in the treatment of acute variceal bleeding. Terlipressin Acetate 1 mg solution for injection is used for the treatment of: bleeding from dilated (widening) veins in the food pipe leading to your stomach (called bleeding oesophageal varices).

Side effects

In clinical trials, the most common side effects of terlipressin administration were paleness, increased blood pressure, peripheral ischemia, abdominal pain, nausea, diarrhea, and headache.
Terlipressin related adverse events are common and most of terlipressin related adverse events were mild or moderate, which can be resolved spontaneously without any intervention. As terlipressin acts mainly on the splanchnic vessels, the incidence of severe ischemic complications is lower with terlipressin than with vasopressin. However, it may cause serious complications such as myocardial infarction, intestinal ischemia, peripheral cyanosis, and skin necrosis[1].

References

[1] Chiang C, et al. Terlipressin-Induced Peripheral Cyanosis in a Patient with Liver Cirrhosis and Hepatorenal Syndrome. American Journal of Case Reports, 2019.

Terlipressin acetate Preparation Products And Raw materials

Raw materials

Preparation Products

Terlipressin acetate Suppliers

Global( 390)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Piramal Pharma Solutions	+919892735994	Maharashtra, India	48	58	Inquiry
PROTECH TELELINKS	+91-8571891912 +91-9855060837	Himachal Pradesh, India	62	58	Inquiry
Manus Aktteva	+91 (79) 6512-3395	New Delhi, India	581	34	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Cellmano Biotech Limited	0551-65326643 18156095617	China	999	58	Inquiry
Apextide Co Ltd	+86-15300650552 +86-15300650552	China	71	58	Inquiry
Hebei Xinsheng New Material Technology Co., LTD.	+86-16632316109	China	1090	58	Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	China	10978	58	Inquiry

Supplier	Advantage
Piramal Pharma Solutions	58
PROTECH TELELINKS	58
Manus Aktteva	34
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Cellmano Biotech Limited	58
Apextide Co Ltd	58
Hebei Xinsheng New Material Technology Co., LTD.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58

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Vasopressin Terlipressin acetate Lypressin

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[N-α-Triglycyl-8-lysine]-vasopressin 130: PN: WO2010033207 SEQID: 171 claiMed protein 1-Triglycyl-8-lysine Vasopressin Nα-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin Nα-Glycyl-glycyl-glycyl-lysine-vasopressin Nα-Glycylglycylglycyl-vasopressin Nα-Gly-Gly-Gly-8-Lys-vasopressin Triglycyl-8-lysine-vasopressin TerlipressinuM Terlipressin acetate, >=98% Terlipressin Diacetate Salt Thymosin al Acetate TERLIPRESSIN ACETATE Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (disulfide bridge 4:9) (2S)-1-[(4S,7S,10S,13S,16S,19S)-19-[[2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]acetyl]amino]-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(1S)-5-amino-1-(carbamoylmethylcarbamoyl)pentyl]pyrrolidine-2-carboxamide N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin N-(GLYCYLGLYCYLGLYCYL)-8-L-LYSINE-VASOPRESSIN H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 acetate salt (Disulfide bond) Glypressin L-Cys(1)-L-Tyr-L-Phe-L-Gln-L-Asn-L-Cys(1)-L-Pro-L-Lys-Gly-N-(Gly-Gly-Gly-)-NH2 Glycylpressin Gly-Gly-Gly-[Lys8]vasopressin Gly-Gly-Gly-L-Cys(1)-L-Tyr-L-Phe-L-Gln-L-Asn-L-Cys(1)-L-Pro-L-Lys-Gly-NH2 Terilipressin Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 Terlipressin, Terlipressine, Terlipressina, Terlipressinum H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH(Disulfide bond) Terlipressin Acetate salt Terlipressin, >99% (2S)-N-[6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[[(4R,7S,10S,13S,16S,19R)-7-(2-amino-2-oxoethyl)-19-[[2-[[2-[(2-amino-1-oxoethyl)amino]-1-oxoethyl]amino]-1-oxoethyl]amino]-10-(3-amino Terlipressin CRS Vasopressin, N-(glycylglycylglycyl)-8-L-lysine- N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin USP/EP/BP TerlipressinuM Glycylpressin N-α-Triglycyl-8-lysine]-vasopressin Terlipressin-15N3-13C6 TerlipressinQ: What is Terlipressin Q: What is the CAS Number of Terlipressin Q: What is the storage condition of Terlipressin Q: What are the applications of Terlipressin Thymosin α1 Acetate 14636-12-5 Terlipressin(net) L-α-amino-n-Butyric acid H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 TERLIPRESSIN Terlipressin for NMR identification 14636-12-5 146363-12-5 156-1-3 C52H74N16O15S2 C52H74N16O15S2C2H4O2 hormones Peptide Amino Acid Derivatives 14636-12-5