15-28-Somatostatin-28
- CAS No.
- 38916-34-6
- Chemical Name:
- 15-28-Somatostatin-28
- Synonyms
- SRIF;SS-14;SRIF-A;GH-RIF;Aminopan;Stilamin;Somatofalk;Modustatina;Somatostatina;Somatostatine
- CBNumber:
- CB6417646
- Molecular Formula:
- C76H104N18O19S2
- Molecular Weight:
- 1637.88
- MOL File:
- 38916-34-6.mol
- Modify Date:
- 2024/5/11 20:10:50
| Melting point | >211°C (dec.) |
|---|---|
| Boiling point | 1970.9±65.0 °C(Predicted) |
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | H2O: 1 mg/mL |
| form | powder |
| pka | 2.94±0.70(Predicted) |
| color | White to Off-White |
| Water Solubility | Soluble in water(25,00°C 1,00 g/L), Methanol. |
| Merck | 13,8788 |
| BRN | 6436064 |
| Sequence | Ala-Gly-c[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys]-OH,(Disulfide bridge: Cys-Cys) |
| InChIKey | NHXLMOGPVYXJNR-ATOGVRKGSA-N |
15-28-Somatostatin-28 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S9129 | Somatostatin ≥97% (HPLC), powder | 38916-34-6 | 0.5MG | ₹7415.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S9129 | Somatostatin ≥97% (HPLC), powder | 38916-34-6 | 1MG | ₹10381.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S9129 | Somatostatin ≥97% (HPLC), powder | 38916-34-6 | 5MG | ₹43808.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S9129 | Somatostatin ≥97% (HPLC), powder | 38916-34-6 | 10MG | ₹77117.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S1763 | Somatostatin powder, BioReagent, suitable for cell culture | 38916-34-6 | 0.1MG | ₹5109.4 | 2022-06-14 | Buy |
15-28-Somatostatin-28 Chemical Properties,Uses,Production
Chemical Properties
White Powder
Definition
ChEBI: A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14.
Biological Functions
Somatostatin is a cyclic 14-peptide that was first isolated by Guillemin in 1973 and is probably the most thoroughly investigated and most important of the inhibitory factors produced by the hypothalamus. The principal activity of somatostatin, which is of hypothalamic origin, is inhibition of the release of growth hormone (GH) from the anterior pituitary. Too much GH, as in pituitary tumors, causes acromegaly, a form of giantism. On the other hand, too little GH leads to dwarfism. Somatostatin also has been found in the pancreas and the GI tract, where it inhibits the secretion of both insulin and glucagon from the pancreas as well as the secretion of a variety of intestinal peptides (e.g., gastrin, secretin, pepsin, and renin). The short half-life of somatostatin, which is less than 3 minutes, has precluded its use as a therapeutic agent. Many derivatives of somatostatin have been prepared to increase its duration of action and/or to enhance its selectivity of action. The culmination of these structure–activity studies was the development of octreotide acetate.
General Description
Somatostatin (SST) is a peptide.
Purification Methods
Somatostatin is a tetradecapeptide which is purified by gel filtration on Sephadex G-25, eluting with 2N AcOH, and then by liquid partition chromatography on Sephadex G-25 using n-BuOH/AcOH/H2O (4:1:5) and has RF = 0.4. It is a brain growth hormone releasing-inhibiting factor which has also been synthesised. [Burgus et al. Proc Natl Acad Sci USA 70 684 1973, Sorantakis & McKinley Biochem Biophys Res Commun 54 234 1973, Hartridt et al. Pharmazie 37 403 1982.]
15-28-Somatostatin-28 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| HEMMO PHARMACEUTICALS PVT. LTD. | +91-22-69026200 | New Delhi, India | 6 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | China | 999 | 58 | Inquiry |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | China | 10978 | 58 | Inquiry |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | China | 616 | 58 | Inquiry |