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Bivalirudin

Bivalirudin Structure
CAS No.
128270-60-0
Chemical Name:
Bivalirudin
Synonyms
BIVALIRUDIN TRIFLUOROACETATE;Bivalirudin Acetate;H-D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH trifluoroacetate salt;BG-8967;Hirulog-1;Bivarudine;BIVALIRUDIN;Bivalirudinum;BITTERMELONP.E;Bivalirudin API
CBNumber:
CB9471951
Molecular Formula:
C98H138N24O33
Molecular Weight:
2180.29
MOL File:
128270-60-0.mol
MSDS File:
SDS
Modify Date:
2024/4/16 14:59:45
Request For Quotation

Bivalirudin Properties

Density 1.52±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility ≥54.5 mg/mL in DMSO with gentle warming; ≥10.18 mg/mL in EtOH with gentle warming and ultrasonic; ≥43.5 mg/mL in H2O with gentle warming
form powder
color white to off-white
Sequence D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH
InChIKey OIRCOABEOLEUMC-GEJPAHFPSA-N

SAFETY

Risk and Safety Statements

Precautionary statements  P271-P261-P280
WGK Germany  3
HS Code  3504009000

Bivalirudin price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML1051 Bivalirudin trifluoroacetate salt ≥97% (HPLC) 128270-60-0 10MG ₹10078.08 2022-06-14 Buy
Sigma-Aldrich(India) SML1051 Bivalirudin trifluoroacetate salt ≥97% (HPLC) 128270-60-0 50MG ₹40269 2022-06-14 Buy
Product number Packaging Price Buy
SML1051 10MG ₹10078.08 Buy
SML1051 50MG ₹40269 Buy

Bivalirudin Chemical Properties,Uses,Production

Description

Bivalirudin was launched in New Zealand as an anticoagulant for i.v. treatment of patients with unstable angina undergoing percutaneous transluminal coronary angioplasty. Bivalirubin is a synthetic 20 amino acid peptide rationally modeled on hirudin (residues 53- 64), the most potent and specific naturally-occuring known inhibitor of thrombin, the enzyme that plays a key role in hemostasis and blood clot formation. This peptide is a direct thrombin inhibitor that maintains the unique bivalent binding properties of hirudin to the catalytic site and to the fibrin-recognition exosite of the enzyme, so acting directly on thrombin with high affinity and specificity. In vitro studies demonstrated that alpha- and zeta-thrombins, both with the higher fibrinogen-procoagulant activities, were inhibited. In rats receiving high doses of bivalirudin, the platelet deposition in carotide was reduced by 63% compared to controls. The results of clinical studies, conducted only in patients receiving concomitant aspirin, suggested that the use of bivalirudin was more efficacious and more predictable than unfractionated heparin, with fewer bleeding complications. Despite some unresolved developmental issues, the attractive properties of this novel agent could make it a useful alternative to heparin in a variety of coagulation disorders.

Uses

Anticoagulant; antithrombotic.

Definition

ChEBI: A synthetic peptide of 20 amino acids, comprising D-Phe, Pro, Arg, Pro, Gly, Gly, Gly, Gly, Asn, Gly, Asp, Phe, Glu, Glu, Ile, Pro, Glu, Glu, Tyr, and Leu in sequence. A congener of hirudin (a naturally occurring drug found in the saliva o the medicinal leech), it a specific and reversible inhibitor of thrombin, and is used as an anticoagulant.

Mechanism of action

Bivalirudin is a rapid-onset, short-acting DTI that binds to both the active site and the exosite-1 of thrombin. Unlike lepirudin, bivalirudin is a reversible inhibitor of both free thrombin and thrombin bound to fibrin. This reversibility is possible because the bound bivalirudin undergoes cleavage at the second N-terminal proline to release the portion of the drug bound to the active site. The carboxyl-terminal portion of bivalirudin dissociates from thrombin to regenerate thrombin. Bivalirudin does not bind to plasma protein.

Pharmacokinetics

Bivalirudin is administered via intravenous bolus injection, followed by continuous infusion (Table 31.4). The drug exhibits a rapid onset and a short duration of action. Bivalirudin is eliminated by renal excretion. It has been suggested that dosage adjustments be made in patients with severe renal impairment and in patients undergoing dialysis. Approximately 30% is eliminated unchanged along with proteolytic cleavage products. Because of the reversible nature of bivalirudin the drug exhibits less risk of bleeding than other antithrombotics, and there have been no reported cases of antibody formation to bivalirudin.

Clinical Use

Bivalirudin, a 20-amino-acid peptide, has been approved for use in patients with unstable angina undergoing percutaneous coronary intervention.

Bivalirudin Preparation Products And Raw materials

Raw materials

ethyl methyl sulfate hydrogen fluoride BOC-Glycine p-Cresol Trifluoroacetic acid
N-(tert-Butoxycarbonyl)-L-phenylalanine BOC-L-Isoleucine Di-tert-butyl dicarbonate BOC-ARG-OH BOC-L-Asparagine
BOC-L-Proline libaotao Hydrogen fluoride L-Tyrosine
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Preparation Products

Bivalirudin Suppliers

Global( 412)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
USV Pvt Ltd +91-2267861111 +91-2225564048 Maharashtra, India 36 58 Inquiry
Sun Pharmaceutical Industries Ltd +91-2242244224 +91-2243244324 Maharashtra, India 108 58 Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
BDR Pharmaceuticals International Pvt Ltd +91-2240560560 +91-7718884418 Maharashtra, India 206 58 Inquiry
Sun Pharmaceutical Industries Ltd. 91-22-43244324 Maharashtra, India 99 58 Inquiry
Manus Aktteva +91 (79) 6512-3395 New Delhi, India 581 34 Inquiry
SUN PHARMACEUTICAL INDUSTRIES LTD (+91 22) 4324 4324 New Delhi, India 175 58 Inquiry
DR REDDYS LABORATORIES LTD +91-40-49002900 New Delhi, India 201 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Supplier Advantage
USV Pvt Ltd 58
Sun Pharmaceutical Industries Ltd 58
Ralington Pharma 58
BDR Pharmaceuticals International Pvt Ltd 58
Sun Pharmaceutical Industries Ltd. 58
Manus Aktteva 34
SUN PHARMACEUTICAL INDUSTRIES LTD 58
DR REDDYS LABORATORIES LTD 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58

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Bivalirudin Spectrum

Bivalirudin(128270-60-0)MS

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Bivalirudin, TFA BIVALIRUDIN BITTERMELONP.E Human Bivalirudin DPHE-PRO-ARG-PRO-GLY-GLY-GLY-GLY-ASN-GLY-ASP-PHE-GLU-GLU-LLE-PRO-GLU-GLU-TYR-LEU Bivalirudin BG 8967, Hirulog, Hirulog I BG 8967, Hirulog, Hirulog I H-D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH Bivalirudin trifluoroacetate salt D-Phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-aspariginylglycyl-L-α-aspartyl-L-phenylalanyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tyrosyl-L-leucine trifluoroacetate Hirulog trifluoroacetate salt Bivalirudin Trifluoacetate Bivalirudinum Bivalirudin Trifluoroacetate, >99% Bivalirudin(Bivalirudin Trifluoroacetate) BG-8967 Hirulog-1 L-Leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-α-aspartyl-L-phenylalanyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tyrosyl- Trifluoroacetate Elcatonin Bivalirudin USP/EP/BP Bivalirudin Thrombin Inhibitor [3-20] bivalirudinQ: What is [3-20] bivalirudin Q: What is the CAS Number of [3-20] bivalirudin BivalirudinQ: What is Bivalirudin Q: What is the CAS Number of Bivalirudin Q: What is the storage condition of Bivalirudin Q: What are the applications of Bivalirudin Bivalirudin API 4'-Trihydroxyisoflavone Than cutting Lu Ding Bivalirudin TFA Salt BIVALIRUDIN TRIFLUOROACETATE Bivalirudin Acetate H-D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH trifluoroacetate salt L-Leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-α-aspartyl-L-phenylalanyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tyrosyl- Bivarudine (S)-4-((S)-2-((S)-2-(2-((S)-2-(2-(2-(2-(2-((S)-1-(D-Phenylalanyl-L-prolyl-L-arginyl)pyrrolidine-2-carboxamido)acetamido)acetamido)acetamido)acetamido)-4-amino-4-oxobutanamido)acetamido)-3-carboxypropanamido)-3-phenylpropanamido)-5-(((S)-4-carboxy-1-(((2S,3S)-1-((S)-2-(((S)-4-carboxy-1-(((S)-4-carboxy-1-(((S)-1-(((S)-1-carboxy-3-methylbutyl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)amino)-1-oxobutan-2-yl)carbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxopentan-2-yl)amino)-1-oxobut Bivalirudin (5 mg) (INTERNATIONAL COLD CHAIN SHIPMENT REQUIRED) 128270-60-0 C98H138N24O33 API proteins Peptide 128270-60-0