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N-(tert-Butoxycarbonyl)-L-phenylalanine

N-(tert-Butoxycarbonyl)-L-phenylalanine Structure
CAS No.
13734-34-4
Chemical Name:
N-(tert-Butoxycarbonyl)-L-phenylalanine
Synonyms
BOC-PHE-OH;BOC-PHE;BOC-L-PHE-OH;BOC-L-PHE;BOC-L-PHENYLALANINE;N-BOC-L-PHENYLALANINE;BOC-PHENYLALANINE;L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-;BOC-ph-OH;BOC Phenly Alanine
CBNumber:
CB4781305
Molecular Formula:
C14H19NO4
Molecular Weight:
265.3
MOL File:
13734-34-4.mol
MSDS File:
SDS
Modify Date:
2024/7/26 17:49:17

N-(tert-Butoxycarbonyl)-L-phenylalanine Properties

Melting point 85-87 °C(lit.)
Boiling point 408.52°C (rough estimate)
Density 1.1356 (rough estimate)
refractive index 24.5 ° (C=1, EtOH)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in methanol, dichloromethane, dimethylformamide and N-methyl-2-pyrrolidone.
form Fine Crystalline Powder
pka 3.88±0.10(Predicted)
color White
optical activity [α]20/D +25±1°, c = 1% in ethanol
BRN 2219729
CAS DataBase Reference 13734-34-4(CAS DataBase Reference)
EPA Substance Registry System L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- (13734-34-4)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280-P271
Hazard Codes  Xn,Xi
Risk Statements  36-22-36/37/38-20/21/22
Safety Statements  39-26-36-24/25
WGK Germany  3
TSCA  Yes
HS Code  29242990
NFPA 704
1
0

N-(tert-Butoxycarbonyl)-L-phenylalanine price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 8.53006 Boc-Phe-OH Novabiochem? 13734-34-4 25G ₹3080.01 2022-06-14 Buy
Sigma-Aldrich(India) 8.53006 Boc-Phe-OH Novabiochem? 13734-34-4 100G ₹6280 2022-06-14 Buy
Sigma-Aldrich(India) 8.53006 Boc-Phe-OH Novabiochem? 13734-34-4 8530061000 ₹84990 2022-06-14 Buy
Sigma-Aldrich(India) 15480 Boc-Phe-OH ≥99.0% (T) 13734-34-4 5G ₹2543.88 2022-06-14 Buy
Sigma-Aldrich(India) 15480 Boc-Phe-OH ≥99.0% (T) 13734-34-4 25G ₹6516.65 2022-06-14 Buy
Product number Packaging Price Buy
8.53006 25G ₹3080.01 Buy
8.53006 100G ₹6280 Buy
8.53006 8530061000 ₹84990 Buy
15480 5G ₹2543.88 Buy
15480 25G ₹6516.65 Buy

N-(tert-Butoxycarbonyl)-L-phenylalanine Chemical Properties,Uses,Production

Chemical Properties

N-(tert-Butoxycarbonyl)-L-phenylalanine is white fine crystalline powder

Uses

N-(tert-Butoxycarbonyl)-L-phenylalanine is used in enantioselective hydrolysis of amino acid esters. Acts as an inhibitor of gastric acid secretion.

Preparation

Sodium hydroxide (4.4 g, 0.11 mol) was placed in a flask, and dissolved in water (110 mL). Phenylalanine (16.5 g, 0.1 mol) was added, the suspension was stirred until a solution was obtained, and then tert-butanol (75 mL) was added. Boc2O (22.3 g, 0.12 mol) was then added with stirring over a period of 1 h, keeping the mixture near 0 ℃. A white precipitate was produced, and at the end of the addition the pH had dropped to 7.5–8.5. The mixture was then carefully acidified by the slow, continuous addition of saturated citric acid to give the product N-tert-butoxycarbonyl-L-phenylalanine (21.5 g, 81%); mp 85℃; [a]21D = t25:5 (c = 1, ethanol).

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n-[(1,1-dimethylethoxy)carbonyl]-l-phenylalanin N-(tert-Butoxycarbonyl)-L-phenylalanine ,98.5% Boc-L-phenylalanine ,98% (2S)-2-(tert-Butoxycarbonylamino)-3-phenylpropionic acid (S)-2-(tert-Butoxycarbonylamino)-3-phenylpropanoic acid N-(tert-Butyloxycarbonyl)-L-phenylalanine N-(tert-butoxycarbonyl)-L-phenylalaninal Boc-L-phenylalanine ,98.5% 2-BOC-AMINO-3-PHENYL-PROPIONIC ACID Boc-L-phenylalanine,N-(tert-Butoxycarbonyl)-L-phenylalanine L-PHENYLALANINE-N-T-BOC (S)-N-(tert-Butoxycarbonyl)phenylalanine tert-Butoxycarbonyl-L-phenylalanine N-Boc-L-phenylalanine Boc-Phe-OH (2S)-2-{[(tert-butoxy)carbonyl]aMino}-3-phenylpropanoic acid Boc-Phe-OH >=99.0% (T) N-(tert-Butoxycarbonyl)-L-phenylalanine SynonyMs N-[(1,1-DiMethylethoxy)carbonyl]-L-phenylalanine Boc-L-phenylalanine≥ 99% (HPLC) BOC-L-Phenylalanine, 99+% BOC-L-Phenylalanine(Boc-Phe-OH) N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANINE(BOC-L-PHE-OH) 2-TERT-BUTOXYCARBONYLAMINO-3-PHENYL-PROPIONIC ACID N-Butoxycarbonyl-L-phenylalanine N-T-BOC-L-PHENYLALANINE FREE ACID N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANINE, 99+% BOC-L-PHENYLALANINE-OH Boc-Phe-OH (Boc-L-Phenylalanine) N-ALPHA-T-BUTYLOXYCARBONYL-L-PHENYLALANINE (2R)-3-phenyl-2-(tert-butoxycarbonylamino)propanoic acid BOC Phenly Alanine BOC-L-PHENYLALANINE extrapure N-(tert-Butoxycarbonyl)-L-phenylalanine, Boc-L-phenylalanine N-TERT-BUTYLOXYCARBONYL-DL-PHENYLALANINE N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANINE N-T-BOC-L-PHENYLALANINE N-T-BUTOXYCARBONYL-L-PHENYLALANINE N-[(1,1-Dimethylethoxy)carbonyl]-L-phenylalanine N-ALPHA-TERT-BUTYLOXYCARBONYL-L-PHENYLALANINE N-ALPHA-T-BUTOXYCARBONYL-L-PHENYLALANINE N-ALPHA-T-BOC-L-PHENYLALANINE T-BUTYLOXYCARBONYL-L-PHENYLALANINE TBOC-L-PHENYLALANINE (S)-2-TERT-BUTOXYCARBONYLAMINO-3-PHENYL-PROPIONIC ACID RARECHEM AL BE 0755 N-Boc-L-phenylalanine,99%e.e. Tert-Butoxycarbonyl L-Phenylalanine (BOC-L Phenylalanine) (Tert-Butoxy)Carbonyl Phe-OH (2S-2-[(2-MethylpropaN-2-Yloxycarbonylamino]-3-Phenylpropanoic Acid N-(tert-Butoxycarbonyl)-L-phenylalanine > BOC-ph-OH N-(tert-Butoxycarbonyl)-L-phenylalanine USP/EP/BP BOC-L-Phenylalanine (Bortezomib Impurity) N-(tert-Butoxycarbonyl)-L-phenylalanine,13734-34-4 L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- BOC-PHE-OH BOC-PHENYLALANINE BOC-PHE BOC-L-PHE