Tetracosactide acetate
- CAS No.
- 16960-16-0
- Chemical Name:
- Tetracosactide acetate
- Synonyms
- TETRACOSACTIDE;synacthen;cortrosyn;tetracosactrin;Tetracosactide CRS;Tetracosactide acetate;SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO;acth-z;C06926;ba30920
- CBNumber:
- CB1325409
- Molecular Formula:
- C136H210N40O31S
- Molecular Weight:
- 2933.44
- MOL File:
- 16960-16-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:00
| Density | 1.47±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | −20°C |
| solubility | Sparingly soluble in water. |
| form | Solid |
| color | White to off-white |
| Water Solubility | Soluble in water |
| Sequence | H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH |
| Stability | Hygroscopic |
| InChIKey | ZOEFCCMDUURGSE-SQKVDDBVSA-N |
| CAS DataBase Reference | 16960-16-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H332-H317-H334 |
| Precautionary statements | P261-P271-P304+P340-P312-P261-P285-P304+P341-P342+P311-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
| WGK Germany | 3 |
| RTECS | GM7915000 |
| HS Code | 2937220000 |
Tetracosactide acetate price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A0298 | Adrenocorticotropic Hormone Fragment 1-24 human, rat ≥97% (HPLC) | 16960-16-0 | 250μG | ₹9601.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A0298 | Adrenocorticotropic Hormone Fragment 1-24 human, rat ≥97% (HPLC) | 16960-16-0 | 1MG | ₹26542.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A0298 | Adrenocorticotropic Hormone Fragment 1-24 human, rat ≥97% (HPLC) | 16960-16-0 | 5MG | ₹103032.35 | 2022-06-14 | Buy |
Tetracosactide acetate Chemical Properties,Uses,Production
Description
Cosyntropin (Tetracosactide acetate) is a synthetic polypeptide that consists of amino acid residues 1 through 24 of human ACTH, but that has the full biological activity of its parent. Because it is of synthetic origin, it is less allergenic than ACTH of natural origin. Cosyntropin is used as a diagnostic agent in the screening of patients suspected of having adrenocortical insufficiency. Normally, parenteral administration of cosyntropin acts rapidly on the adrenal cortex to effect release of plasma hydrocortisone; when performing the test, the hydrocortisone levels are compared to a control blood sample taken earlier.
Chemical Properties
White or yellow, amorphous powder.
Indications
Cosyntropin (Cortrosyn) is a polypeptide that consists solely of the first 24 amino acids of corticotropin. It appears to offer an advantage over the naturally occurring hormone in that it has a longer duration of action and lacks the antigenic portion of corticotropin. Although the short cosyntropin test is recognized as a valid screening test to assess adrenocortical insufficiency, the overnight metyrapone test or insulin hypoglycemia test may prove more sensitive.
Definition
ChEBI: A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of adrenocorticotropic hormone (corticotropin). A segment similar in all species, it contains the biological activity that stimulates production of cort costeroids in the adrenal cortex. It is used diagnostically to investigate adrenocortical insufficiency.
General Description
Cosyntropin (Cortrosyn) is a syntheticpeptide containing the first 24 amino acids of natural corticotropin.Cosyntropin is used as a diagnostic agent to testfor adrenal cortical deficiency. Plasma hydrocortisone concentrationis determined before and 30 minutes after theadministration of 250 g of cosyntropin. Most normal responses result in an approximate doubling of the basalhydrocortisone concentration in 30 to 60 minutes. If the responseis not normal, adrenal insufficiency is indicated.Such adrenal insufficiency could be a result of either adrenalor pituitary malfunction, and further testing is requiredto distinguish between the two. Cosyntropin (250 μg infusedwithin 4–8 hours) or corticotropin (80–120 U/day for3–4 days) is administered. Patients with functional adrenaltissue should respond to this dosage. Patients who respondaccordingly are suspected of hypopituitarism, and the diagnosiscan be confirmed by other tests for pituitary function.Patients who have Addison disease, however, show little orno response.
Biological Activity
Tetracosactide Acetate (SR-TA) stimulates the release of corticosteroids such as cortisol from the adrenal gland. It is absorbed into a zinc phosphate complex, which ensures the sustained release of the active substance from the intramuscular injection site. SR-TA is currently used to manage ulcerative colitis, Crohn's disease, juvenile/adult rheumatoid arthritis, and osteoarthrosis[1].
Side effects
Common side effects of Tetracosactide acetate may include: an allergic reaction (hives; difficult breathing; swelling of your face, lips, tongue, or throat); fast or slow heartbeats; increased blood pressure; rash; swelling in your hands or feet.
References
[1] F. Iuliano, M. Rossi, Eleonora Iuliano. “Adding Slow Release Tetracosactide Acetate to Eltrombopag Improves Haematological Response in ITP Patients with Platelet-Count Fluctuation.” Blood (2018).
Tetracosactide acetate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Piramal Pharma Solutions | +919892735994 | Maharashtra, India | 48 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Trichem Healthcare Pvt., Ltd. | 91-22-66083333 | Maharashtra, India | 11 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Global Chem Asia Pacific | 91-9849161572 | Hyderabad, India | 255 | 58 | Inquiry |
| Congruent Pharmachem Pvt., Ltd. | 91-9987911266 | Maharashtra, India | 35 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Hemmo Pharmaceuticals Pvt., Ltd. | 91-22-43546200 | Maharashtra, India | 3 | 58 | Inquiry |
| Ralington Pharma | 91-79-48911722 | Gujarat, India | 312 | 58 | Inquiry |
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