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Lecirelin

Lecirelin Structure
CAS No.
61012-19-9
Chemical Name:
Lecirelin
Synonyms
LEC;LECIRELIN;Supergestran;Lecirelin, BR;SUPERGESTRAN(TM);Lecirelin Acetate;(D-TLE6)-LEUPROLIDE;DalMarelin Acetate;LECIRELIN USP/EP/BP;(D-TLE6)-LEUPRORELIN
CBNumber:
CB3209815
Molecular Formula:
C59H84N16O12
Molecular Weight:
1209.42
MOL File:
61012-19-9.mol
Modify Date:
2024/10/23 13:36:13
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Lecirelin Properties

Density 1.44
storage temp. Store at -20°C
solubility DMSO : 12.1 mg/mL (10.00 mM)
form Solid
pka 9.82±0.15(Predicted)
color White to off-white
InChIKey XJWIEWPGHRSZJM-JUAATNMYNA-N

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H360

Lecirelin Chemical Properties,Uses,Production

Uses

Mammalian LHRHa containing Supergestran was used to stimulate the spermiation of tench males. Half dose of lecirelin was almost equally effective to induce the disappearance of the dominant follicle at Day 6 to 7 of the estrous cycle in three GnRH analogs of cattle.

Definition

Lecirelin, a synthetic gonadotropin-releasing hormone (GnRH) analog, acts as a GnRH agonist. Lecirelin is widely used for the research of bovine ovarian follicular cysts. lecithin and buserelin, two nonapeptides, are used as the acetate. Lecirelin differs by substitution of D-tertiary leucine for glycine at position 6 and the replacement of glycine by ethylamide at position 10. Buserelin has a D-serine at position 6 and ethylamide at position 10.

in vitro

Lecirelin (2.07 μM) significantly increases the tension and frequency of contractions in preovulatory follicles (PF), small follicular cysts (FC-S), and large follicular cysts (FC-L). Lecirelin increases the strips from preovulatory follicles contract significantly more than strips from cysts.

References

[1] Picard-Hagen N, et al. Effect of gonadorelin, lecirelin, and buserelin on LH surge, ovulation, and progesterone in cattle. Theriogenology, 2015; 84: 177-183.

Lecirelin Preparation Products And Raw materials

Raw materials

Preparation Products

Lecirelin Suppliers

Global( 133)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6739 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6754 58 Inquiry
qingdao future trading Co., Ltd +86-13335044410 +86-13335044410 China 110 58 Inquiry
Shanghai Getian Industrial Co., LTD +86-15373193816 +86-15373193816 China 269 58 Inquiry
Shandong Deshang Chemical Co., Ltd. +86-0531-8875-2665 +8613153039501 China 662 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29880 58 Inquiry
Shenzhen Nexconn Pharmatechs Ltd +86-755-89396905 +86-15013857715 China 10311 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39894 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
qingdao future trading Co., Ltd 58
Shanghai Getian Industrial Co., LTD 58
Shandong Deshang Chemical Co., Ltd. 58
career henan chemical co 58
Shenzhen Nexconn Pharmatechs Ltd 58
BOC Sciences 58
Chongqing Chemdad Co., Ltd 58

61012-19-9(Lecirelin)Related Search:

GRF (1-44) (HUMAN) ARG-LYS-GLU-VAL-TYR ACETATE SALT CRF(Ovine)Trifluoroacetate Endothelin-1 (human, porcine) Terlipressin acetate
Liraglutide Ornipressin Triptorelin Teriparatide acetate Amyloid β-Peptide (1-42) (human)
CRF (HUMAN, RAT) Vasopressin Abarelix FERTIRELIN Octreotide
Leuprorelin Lecirelin PYR-HIS-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-NHET
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SUPERGESTRAN(TM) PYR-HIS-TRP-SER-TYR-TBU-D-GLY-LEU-ARG-PRO-NHET Lecirelin(6-(3-methyl-D-valine)-9-(N-ethyl-L-prolynamide)-10-deglycinamide) (DES-GLY10,TBU-D-GLY6,PRO-NHET9)-LHRH (D-TLE6)-LEUPROLIDE (D-TLE6)-LEUPRORELIN [D-TLE6,PRO-NHET9]-LHRH GLP-HIS-TRP-SER-TYR-TLE-LEU-ARG-PRO-NHET LECIRELIN (Des-Gly10,tBu-D-Gly6,Pro-NHEt9)-LHRH (D-Tle6)-Leuprolide, (D-Tle6)-Leuprorelin, Lecirelin (D-Tle6)-Leuprolide, (D-Tle6)-Leuprorelin, Lecirelin 6-(3-Methyl-D-valine)-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing hormone-releasing factor (pig) Supergestran Lecirelin (Dalmarelin) Acetate LECIRELIN (DALMARELIN) ACETATE Lecirelin, (D-Tle6)-Leuprolide, (D-Tle6)-Leuprorelin, DalMarelin Lecirelin Acetate DalMarelin Acetate 1-9-LuteinizinghorMone-releasing factor (swine),6-(3-Methyl-D-valine)-9-(N-ethyl-L-prolinaMide)- Lecirelin, BR (Des-Gly10, tBu-D-Gly6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-tBu-D-Gly-Leu-Arg-Pro-NHEt acetate salt (Des-Gly10, tBu-D-Gly6,Pro-NHEt 9)-LHRH trifluoroacetate salt Pyr-His-Trp-Ser-Tyr-tBu-D-Gly-Leu-Arg-Pro-NHEt trifluoroacetate salt LECIRELIN USP/EP/BP Lecirelin acetate salt Lecirelin/Supergestran (Des-Gly??,tBu-D-Gly?,Pro-NHEt?)-LHRH trifluoroacetate salt LEC 61012-19-9 C59H84N16O12 C59H84N16O12xC2HF3O2 C59H84N16O12xC2H4O2 61012-19-9