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Amyloid β-Peptide (1-42) (human)

Amyloid β-Peptide (1-42) (human) Structure
CAS No.
107761-42-2
Chemical Name:
Amyloid β-Peptide (1-42) (human)
Synonyms
TB500;Soy Peptide Powder;DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA;DA-42;soy peptide;β-Amyloid-42;Soy Oligopeptides;Amyloid β Protein Fragment 1-42;Amyloid β-Peptide (1-42) (human);Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
CBNumber:
CB2139797
Molecular Formula:
C203H311N55O60S1
Molecular Weight:
4514.04
MOL File:
107761-42-2.mol
MSDS File:
SDS
Modify Date:
2025/1/27 9:38:02
Request For Quotation

Amyloid β-Peptide (1-42) (human) Properties

Melting point 205 °C
Density 0.23 g/cm3
storage temp. -20°C
solubility Soluble in ammonium hydroxide, pH >9. Also soluble in DMSO.
form Lyophilized
color Lyophilized White
Odor Odorless
Sequence H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
InChIKey XPESWQNHKICWDY-QYFPAAMGSA-N
CAS DataBase Reference 107761-42-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Safety Statements  24/25
WGK Germany  3
HS Code  29332900

Amyloid β-Peptide (1-42) (human) price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) A9810 Amyloid β Protein Fragment 1-42 107761-42-2 0.1MG ₹26174.85 2022-06-14 Buy
Sigma-Aldrich(India) 171596 β-Amyloid Peptide (1-42), Rat Predominant peptide found in the brain of patients with Alzheimer''s Disease and Down''s Syndrome. Promotes down-regulation of Bcl-2 and upregulation 107761-42-2 250μG ₹33320 2022-06-14 Buy
Product number Packaging Price Buy
A9810 0.1MG ₹26174.85 Buy
171596 250μG ₹33320 Buy

Amyloid β-Peptide (1-42) (human) Chemical Properties,Uses,Production

Chemical Properties

Lyophilized White solid, with no soy flavor, no protein denaturation, acidic non-precipitation, heating does not coagulate, easily soluble in water, good fluidity, and other good processing properties, is an excellent health food material.

Uses

Amyloid β-Peptide (1-42) (human)[107761-42-2], a major component of amyloid plaques, accumulates in neurons of Alzheimer's disease brains. Aβ(s) peptides, their peptide fragments and mutated fragments are used to study a wide range of metabolic and regulatory functions including activation of kinases, regulation of cholesterol transport, function as a transcription factor, and regulators of inflammation. Aβ(s) peptides and their peptide fragments are also used to study oxidative stress, metal binding and mechanisms of protein cross-linking in the context of diseases such as Alzheimer's disease and neurodegeneration.

Application

Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Beta-Amyloid (1-42) human is used as follows:
for the production of Aβ-1-42 oligomer;
in western blot analysis;
for interference testing of immunomagnetic reduction (IMR) plasma Aβ42 assay;
to study the effect of resveratrol on Aβ-1-42-induced impairment of spatial learning, memory, and synaptic plasticity;
to investigate the effect of Aβ in epithelial cell cultures.

General Description

Amyloid β Protein is produced from amyloid-β precursor protein (APP). It consists of two C terminal variants, such as a long tailed Aβ 1-42 and a short tailed Aβ 1-40. APP is located on human chromosome 21q21.3.

Biochem/physiol Actions

Amyloid β-Peptide (1-42) (human) is a human form of the predominant amyloid β-peptide found in the brains of patients with Alzheimer's disease. Amyloid β Protein Fragment 1-42 (Aβ 1-42) has antioxidant and neuroprotective properties. Accumulation of amyloid β Protein is associated with Alzheimer′s disease (AD) and Down Syndrome. Aβ 1-42 regulates cholesterol transport and may function as a transcription factor. It may possess anti-inflammatory and antimicrobial properties. Downregulates bcl-2 and increases the levels of bax. Neurotoxic.

References

[1] CHEN L M, CHAI K X. Matriptase cleaves the amyloid-beta peptide 1–42 at Arg-5, Lys-16, and Lys-28[J]. BMC Research Notes, 2019, 12. DOI:10.1186/s13104-018-4040-z.
[2] BROWN A M, BEVAN D R. Influence of sequence and lipid type on membrane perturbation by human and rat amyloid β-peptide (1-42).[J]. Archives of biochemistry and biophysics, 2015, 614: 1-13. DOI:10.1016/j.abb.2016.11.006.
[3] MENGTING YANG. Gel Phase Membrane Retards Amyloid β-Peptide (1–42) Fibrillation by Restricting Slaved Diffusion of Peptides on Lipid Bilayers[J]. Langmuir, 2018, 34 28: 8408-8414. DOI:10.1021/acs.langmuir.8b01315.
[4] LIANG SHEN Hong F J. Comparative study on the conformational stability of human and murine amyloid β peptide[J]. Computational and Theoretical Chemistry, 2011, 972 1: Pages 44-47. DOI:10.1016/j.comptc.2011.06.012.
[5] MOUCHARD A, BOUTONNET M C, MAZZOCCO C, et al. ApoE-fragment/Aβ heteromers in the brain of patients with Alzheimer’s disease[J]. Scientific Reports, 2019, 9. DOI:10.1038/s41598-019-40438-4.

Amyloid β-Peptide (1-42) (human) Preparation Products And Raw materials

Raw materials

Bacillus subtilis SOYBEAN MEAL Complex enzyme EC 3.4.21.14 PROTEASE

Preparation Products

Amyloid β-Peptide (1-42) (human) Suppliers

Global( 322)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
Shrushti Enterprises 08048372303Ext 823 Maharashtra, India 18 58 Inquiry
Shanghai Longyu Biotechnology Co., Ltd. +8619521488211 China 2555 58 Inquiry
Hebei Xunou new energy Technology Co., LTD +86-17531957005; +undefined17531957005 China 36 58 Inquiry
Wuhan Cell Pharmaceutical Co., Ltd +86-13129979210 +86-13129979210 China 376 58 Inquiry
Anko Intermational Trade Limited +86-18073326374 +86-18073326374 China 58 58 Inquiry
Shanghai Getian Industrial Co., LTD +86-15373193816 +86-15373193816 China 269 58 Inquiry
Strong peptide cross-border e-commerce Co. LTD +undefined13930052870 China 84 58 Inquiry
Huaian Banting Trading Co., Ltd. +8618875735705 China 57 58 Inquiry
Hebei Chuanghai Biotechnology Co., Ltd +8615531157085 China 8808 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Shrushti Enterprises 58
Shanghai Longyu Biotechnology Co., Ltd. 58
Hebei Xunou new energy Technology Co., LTD 58
Wuhan Cell Pharmaceutical Co., Ltd 58
Anko Intermational Trade Limited 58
Shanghai Getian Industrial Co., LTD 58
Strong peptide cross-border e-commerce Co. LTD 58
Huaian Banting Trading Co., Ltd. 58
Hebei Chuanghai Biotechnology Co., Ltd 58

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Bate-Amyloid（1-42）human (1-42) (human) AB42, betaamyloid peptide Amyloid &beta H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH REF DUPL: H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH Beta-Amyloid (1-42), sodium salt Β-AMYLOID PEPTIDE (1-42), RAT AMyloid (1-42) huMan peptide HuMan β-aMyloid peptide-(1-42) AMyloid b-Protein (1-42) β-AMyloid Peptide (1-42),rat,β-AMyloid Peptide (1-42),rat Beta-AMyloid(1-42)TB500 L-alpha-Aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-serylglycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-L-valyl-L-isoleucyl-L-alanine M.W. 4514.08 C203H311N55O60S Amyloid beta Protein fragment 1-42 HCl Salt Human beta-amyloid peptide (1-42) Amyloid β-Protein (1-42) hydrochloride salt Bate-Amyloid(1-42) BETA-AMYLOID PEPTIDE (1-42), HUMAN AMYLOID BETA-PEPTIDE (1-42) (HUMAN) AMYLOID B-PROTEIN FRAGMENT 1-42 Amyloidb-Peptide(1-42)(human) H-Asp-Ala-Glu-Phe-Arg-His-Asp--Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-OH SS-AMYLOID PEPTIDE (1-42), RAT H-asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Gly-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Ile-Ala-OH beta-Amyloid (1-42) human Amyloid beta-Protein (1-42) hydrochloride salt H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH hydrochloride salt Amyloid beta-Protein (1-42) sodium salt Amyloid beta-Protein (1-42) trifluoroacetate salt H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH trifluoroacetate salt Amyloid β-Peptide (1-42) (human) TFA β-Amyloid: 1-42,human Amyloid β-Peptide (12-28) (human) Amyloid β-Peptide (1-42) beta-Amyloid (1-42) human USP/EP/BP β-Amyloid (1-42), human TFA Amyloid β-Protein (1-42) β–Amyloid (1-42), human, Amyloid β-Protein (Human, 1-42) Amyloid-β (1-42) Peptide Amyloid|A-Peptide (1-42) (human) Amyloid β Protein Fragment 1-42, ≥95% (HPLC) Amyloid β-Protein (1-42) (HFIP-treated) Amyloid β-Protein (1-42) sodium salt β–Amyloid (1-42), Amyloid β-Protein (Human, 1-42) 2-Amyloid(1-42) Human 1-42 Amyloid β Protein Fragment 1-42,human Amyloid β-Peptide (1-42) (human) TB500 DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA Amyloid β Protein Fragment 1-42 DA-42 Soy Peptide Powder Soy Oligopeptides soy peptide Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala β-Amyloid-42 beta-Amyloid (1-42) human/TB500 beta-Amyloid (1-42) humanbeta-Amyloid