Amyloid β-Peptide (1-42) (human)

Amyloid β-Peptide (1-42) (human) C화학적 특성, 용도, 생산

화학적 성질

Lyophilized White solid, with no soy flavor, no protein denaturation, acidic non-precipitation, heating does not coagulate, easily soluble in water, good fluidity, and other good processing properties, is an excellent health food material.

용도

Amyloid β-Peptide (1-42) (human)[107761-42-2], a major component of amyloid plaques, accumulates in neurons of Alzheimer's disease brains. Aβ(s) peptides, their peptide fragments and mutated fragments are used to study a wide range of metabolic and regulatory functions including activation of kinases, regulation of cholesterol transport, function as a transcription factor, and regulators of inflammation. Aβ(s) peptides and their peptide fragments are also used to study oxidative stress, metal binding and mechanisms of protein cross-linking in the context of diseases such as Alzheimer's disease and neurodegeneration.

주요 응용

Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Beta-Amyloid (1-42) human is used as follows:
for the production of Aβ-1-42 oligomer;
in western blot analysis;
for interference testing of immunomagnetic reduction (IMR) plasma Aβ42 assay;
to study the effect of resveratrol on Aβ-1-42-induced impairment of spatial learning, memory, and synaptic plasticity;
to investigate the effect of Aβ in epithelial cell cultures.

일반 설명

Amyloid β Protein is produced from amyloid-β precursor protein (APP). It consists of two C terminal variants, such as a long tailed Aβ 1-42 and a short tailed Aβ 1-40. APP is located on human chromosome 21q21.3.

Biochem/physiol Actions

Amyloid β-Peptide (1-42) (human) is a human form of the predominant amyloid β-peptide found in the brains of patients with Alzheimer's disease. Amyloid β Protein Fragment 1-42 (Aβ 1-42) has antioxidant and neuroprotective properties. Accumulation of amyloid β Protein is associated with Alzheimer′s disease (AD) and Down Syndrome. Aβ 1-42 regulates cholesterol transport and may function as a transcription factor. It may possess anti-inflammatory and antimicrobial properties. Downregulates bcl-2 and increases the levels of bax. Neurotoxic.

참고 문헌

[1] CHEN L M, CHAI K X. Matriptase cleaves the amyloid-beta peptide 1–42 at Arg-5, Lys-16, and Lys-28[J]. BMC Research Notes, 2019, 12. DOI:10.1186/s13104-018-4040-z.
[2] BROWN A M, BEVAN D R. Influence of sequence and lipid type on membrane perturbation by human and rat amyloid β-peptide (1-42).[J]. Archives of biochemistry and biophysics, 2015, 614: 1-13. DOI:10.1016/j.abb.2016.11.006.
[3] MENGTING YANG. Gel Phase Membrane Retards Amyloid β-Peptide (1–42) Fibrillation by Restricting Slaved Diffusion of Peptides on Lipid Bilayers[J]. Langmuir, 2018, 34 28: 8408-8414. DOI:10.1021/acs.langmuir.8b01315.
[4] LIANG SHEN Hong F J. Comparative study on the conformational stability of human and murine amyloid β peptide[J]. Computational and Theoretical Chemistry, 2011, 972 1: Pages 44-47. DOI:10.1016/j.comptc.2011.06.012.
[5] MOUCHARD A, BOUTONNET M C, MAZZOCCO C, et al. ApoE-fragment/Aβ heteromers in the brain of patients with Alzheimer’s disease[J]. Scientific Reports, 2019, 9. DOI:10.1038/s41598-019-40438-4.

Amyloid β-Peptide (1-42) (human) 준비 용품 및 원자재

원자재

준비 용품

Amyloid β-Peptide (1-42) (human) 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai Longyu Biotechnology Co., Ltd.	+8613917842738	info@longyupharma.com	China	2534	58
Sigma Audley	+86-18336680971 +86-18126314766	nova@sh-teruiop.com	China	515	58
Wuhan Cell Pharmaceutical Co., Ltd	+86-13129979210 +86-13129979210	sales@cellwh.com	China	376	58
Zhuzhou New Peptides Tech Co.,Ltd.	+86-18073326374 +86-18073326374	sales@goodpeptides.com	China	145	58
Hebei Xunou new energy Technology Co., LTD	+undefined17531957005	xunou8@hbxunou.com	China	36	58
Shanghai Affida new material science and technology center	+undefined15081010295	admin@oudaxin.com	China	114	58
Shanghai Getian Industrial Co., LTD	+86-15373193816 +86-15373193816	mike@ge-tian.com	China	274	58
Strong peptide cross-border e-commerce Co. LTD	+undefined13930052870	qt01@qiangtaipharm.com	China	81	58
CONTIDE BIOTECH CO.,LTD	+852-53358525	xena@healthtide-api.com	China	589	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12462	58

Amyloid β-Peptide (1-42) (human) 관련 검색: