Oxytocin
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Oxytocin 속성
- 녹는점
- 192-194°C
- 알파
- D22 -26.2° (c = 0.53)
- 끓는 점
- 1533.3±65.0 °C(Predicted)
- 밀도
- 1.1086 (rough estimate)
- 굴절률
- 1.6700 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 물에 매우 잘 녹습니다. 아세트산과 에탄올의 묽은 용액(96%)에 용해됩니다.
- 물리적 상태
- 동결건조된 분말
- 산도 계수 (pKa)
- pKa ~6.1(free amino group on Cys) (Occasionally);~10(free phenol on Tyr) (Occasionally)
- 색상
- 하얀색
- 수용성
- 물에 용해됩니다.
- Merck
- 13,7049
- BRN
- 3586108
- InChIKey
- DSZOEVVLZMNAEH-BXUJZNQYSA-N
- CAS 데이터베이스
- 50-56-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
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위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36 | ||
유엔번호(UN No.) | 3249 | ||
WGK 독일 | 3 | ||
RTECS 번호 | RS7534000 | ||
F 고인화성물질 | 3-8-10-23 | ||
위험 등급 | 6.1(a) | ||
포장분류 | II | ||
HS 번호 | 2937190000 | ||
유해 물질 데이터 | 50-56-6(Hazardous Substances Data) | ||
독성 | LD50 oral in rat: > 20520ug/kg |
그림문자(GHS): | ||||||||||||||||||||||
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신호 어: | Warning | |||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Oxytocin C화학적 특성, 용도, 생산
개요
Oxytocin is a peptide hormone containing nine amino acids secreted and synthesized by the paraventricular and supraoptic nuclei of the hypothalamus and stored and released by the neurohypophysis. It acts in females by inducing uterine contractions during parturition and stimulating milk ejection by the mammary glands. No actions in males are known. Synthetic derivatives of oxytocin are used to induce labor and for therapeutic abortions. In recent years the safety of oxytocin has been greatly enhanced by the use of continuous maternal and fetal monitoring and by the use of controlled intravenous infusion of the drug.화학적 성질
Oxytocin is a white to yellowish brown powder, hygroscopic, easily soluble in water. It is a synthetic cyclic nonapeptide having the structure of the hormone produced by the posterior lobe of the pituitary gland that stimulates contraction of the uterus and milk ejection in receptive mammals.정의
ChEBI: Oxytocin is a cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain; the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary. Together with the neuropeptide vasopressin, it is believed to influence social cognition and behaviour. It has a role as an oxytocic and a vasodilator agent. It is a peptide hormone and a heterodetic cyclic peptide.Biosynthesis
Oxytocin is a cyclic nonapeptide that differs from vasopressin by only 2 amino acids. It is synthesized as a larger precursor molecule in cell bodies of the paraventricular nucleus, and to a lesser extent, the supraoptic nucleus in the hypothalamus. The precursor is rapidly converted by proteolysis to the active hormone and its neurophysin, packaged into secretory granules as an oxytocin-neurophysin complex, and secreted from nerve endings that terminate primarily in the posterior pituitary gland. In addition, oxytocinergic neurons that regulate the autonomic nervous system project to regions of the hypothalamus, brainstem, and spinal cord. Other sites of oxytocin synthesis include the luteal cells of the ovary, the endometrium, and the placenta.일반 설명
Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns, where first exon codes for hormone OXT while other exon codes for neurophysin I.건강위험
Uterine contraction, milk ejection, facilitates sperm ascent in female tractDecreases membrane potential of myometrium, basic metabolic rate, and liver glycogen
Stimulates oviposition in hen, releases luteinizing hormone (LH)
Increases blood sugar and urinary sodium and potassium
Safety Profile
Poison by intravenous route. Experimental reproductive effects. Oxytocin is a pituitary hormone which stimulates uterine contraction and milk production. The principal uterus-contracting and lactation-stimulating hormone of the posterior pituitary gland.Purification Methods
It is a cyclic nonapeptide which is purified by countercurrent distribution between solvent and buffer. It is soluble in H2O, n-BuOH and isoBuOH. [Bodanszky & du Vigneaud J Am Chem Soc 81 2504 1959, Cash et al. J Med Pharm Chem 5 413 1962, Sakakibara et al. Bull Chem Soc Jpn 38 120 1965; solid phase synthesis: Bayer & Hagenmyer Tetrahedron Lett 2037 1968.] It was also synthesised on a solid phase matrix and finally purified as follows: A Sephadex G-25 column is equilibrated with the aqueous phase of a mixture of 3.5% AcOH (containing 1.5% of pyridine)/n-BuOH/*C6H6 (2:1:1) and then the organic phase of this mixture is run through. A solution of oxytocin (100mg) in H2O (2mL) is applied to the column which is then eluted with the organic layer of the above mixture. The fractions containing the major peak [as determined by the Folin-Lowry protein assay: Fryer et al. Anal Biochem 153 262 1986] are pooled, diluted with twice their volume of H2O, evaporated to a small volume and lyophilised to give oxytocin as a pure white powder (20mg, 508 U/mg). [Ives Can J Chem 46 2318 1968, Beilstein 22 III/IV 82.]Oxytocin 준비 용품 및 원자재
원자재
Vasopressin
퍼콜
벤토나이트
5-설포살리실산 이수화물
제오라이트
산화규소
암모니아(가스)
수소
염산
Glycinamide, L-cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucyl-
Fmoc-Asn(Trt)-OH
Fmoc-Tyr(tBu)-OH
Fmoc-Pro-OH
Fmoc-Leu-OH
Fmoc-Ile-OH
Fmoc-Gly-OH
준비 용품
Oxytocin 공급 업체
글로벌( 506)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 |
admin@guyunchem.com | China | 616 | 58 |
Cellmano Biotech Limited | 0551-65326643 18156095617 |
info@cellmano.com | China | 999 | 58 |
Zhuzhou New Peptides Tech Co.,Ltd. | +86-18073326374 +86-18073326374 |
sales@goodpeptides.com | China | 145 | 58 |
Apextide Co Ltd | +86-15300650552 +86-15300650552 |
info@apextide.com | China | 71 | 58 |
Hebei Xunou new energy Technology Co., LTD | +undefined17531957005 |
xunou8@hbxunou.com | China | 36 | 58 |
Hebei Weimiao Import and Export Trade Co., Ltd. | +undefined19948166995 |
sale01@hbweimiao.com | China | 73 | 58 |
Shanghai Affida new material science and technology center | +undefined15081010295 |
admin@oudaxin.com | China | 114 | 58 |
Shanghai Likang New Materials Co., Limited | +86-16631818819 +86-17736933208 |
3684455296@qq.com | China | 9311 | 58 |
Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 |
info@hyper-chem.com | China | 265 | 58 |
Shanghai Yunao International Trade Co., Ltd | +8617621705551 |
asdf@shanghaihg.cn | China | 265 | 58 |
Oxytocin 관련 검색:
트리스(하이드록시메틸)아미노메탄 6-아미노 카프로산 3-아미노페놀 글리신
Bivalirudin
Teriparatide acetate
Amyloid β-Peptide (1-42) (human)
ALTRENOGEST
ISOTOCIN
Oxytocin Impurtiy
Oxytocin free acid
(PHE2,ORN8)-OXYTOCIN
CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2
Oxytocin acetate
(+-) 1-BROMO-2-METHYLBUTANE 95
Carbetocin
CYS-TYR-ILE-GLN-ASN-CYS-PRO-ARG-GLY-NH2
Cargutocin