β-Boswellic Acid
- CAS No.
- 631-69-6
- Chemical Name:
- β-Boswellic Acid
- Synonyms
- BRN0077366;Masticinic acid;B-BOSWELLIC ACID;Β-BOSWELLIC ACID;β-Boswellic Acid;BOSWELLIC ACID, B-;BETA-BOSWELLIC ACID;BOSWELLIC ACID, a-(P);β-Boswellic Acid USP/EP/BP;NBGQZFQREPIKMG-PONOSELZSA-N
- CBNumber:
- CB4427357
- Molecular Formula:
- C30H48O3
- Molecular Weight:
- 456.71
- MOL File:
- 631-69-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:09
| Melting point | 130-135°C |
|---|---|
| alpha | D +107° (c = 0.75 in CHCl3) |
| Boiling point | 556.0±50.0 °C(Predicted) |
| Density | 1.09±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| pka | 4.50±0.70(Predicted) |
| form | Solid |
| color | Off-White |
| Water Solubility | practically insoluble in water |
| InChIKey | NBGQZFQREPIKMG-AKOQEMLPSA-N |
| LogP | 9.105 (est) |
| CAS DataBase Reference | 631-69-6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
β-Boswellic Acid Chemical Properties,Uses,Production
Description
β-Boswellic acid is a pentacyclic triterpene originally isolated from Boswellia that has diverse bioactivities. It inhibits 5-lipoxygenase (5-LO) with an IC50 value of approximately 5 μM but is less potent than its derivative 3-acetyl-11-keto-β-boswellic acid . It inhibits cell proliferation in HL-60 cells with IC50 values of 3.7, 7.1, and 6.3 μM for DNA, RNA, and protein synthesis, respectively. In human umbilical vein endothelial cells (HUVECs) transiently deprived of oxygen and glucose, β-boswellic acid increases nitric oxide and increases phosphorylation of enzyme nitric oxide synthase (eNOS). It also increases calcium mobilization in platelets at concentrations ≥3 μM and induces platelet aggregation (EC50 = 8 μM).
Chemical Properties
BETA-BOSWELLIC ACID is Off-White Solid
Uses
The principal constitutents of frankincense (olibanum). A specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation.
Anticancer Research
It is a natural pentacyclic triterpenediol and occurs in Boswellia serrata plants as anisomeric blend of 3α, 24-dihydroxyolean-12-ene and 3α, 24-dihydroxyurs-12-ene.It induces apoptosis in various cancer cells. The events involved in this process areexcessive reactive oxygen species (ROS), nitric oxide (NO) formation, DNA ladderformation, and increased sub-G0 phase in cell cycle. This ultimately results incleavage of Bcl-2 and translocation of Bax to mitochondria, which lead to the lossof mitochondrial potential and release of cyt-c and other factors into cytosol. All these events are linked with reduced expression of survivin and inhibitor of caspase-activatedDNases (ICAD) that leads to the activation of poly(ADP-ribose) polymerase(PARP). The triterpene upregulates the expression of cell death receptor-4(DR-4) and tumor necrosis factor receptor-1 (TNF-R1), where both lead to activationof caspase-8 (Huang et al. 2000; Desai et al. 2008; Lu et al. 2008).
β-Boswellic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| VIVAN Life Sciences Pvt. Limited. | +91(22) 2544 4584 / 2544 4585 | New Delhi, India | 138 | 50 | Inquiry |
| Natural Remedies Pvt Ltd | +91 (80) 4020-9999 | New Delhi, India | 110 | 50 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | China | 12456 | 58 | Inquiry |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | China | 2989 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | CHINA | 1824 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860 +86-18080483897 | China | 3424 | 58 | Inquiry |
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