3-METHYLCHOLANTHRENE
- CAS No.
- 56-49-5
- Chemical Name:
- 3-METHYLCHOLANTHRENE
- Synonyms
- 3-MC;3-Methyl-1,2-dihydrocyclopenta[ij]tetraphene;20-MC;3-mch;3-MCA;3-meca;NSC 21970;3-Methylcholan;Methylcholanthrene;3-methylcholanthren
- CBNumber:
- CB4437350
- Molecular Formula:
- C21H16
- Molecular Weight:
- 268.35
- MOL File:
- 56-49-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/4/23 13:52:06
| Melting point | 178-180 °C (lit.) |
|---|---|
| Boiling point | 280 °C/80 mmHg (lit.) |
| Density | 1.28 g/cm3 (20℃) |
| refractive index | 1.4664 (estimate) |
| Flash point | -5 °C |
| storage temp. | room temp |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| color | Yellow to Dark Yellow |
| Water Solubility | 2.9ug/L(25 ºC) |
| Merck | 13,6072 |
| BRN | 1913890 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 56-49-5(CAS DataBase Reference) |
| EPA Substance Registry System | 3-Methylcholanthrene (56-49-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H350-H413 | |||||||||
| Precautionary statements | P201-P273-P308+P313 | |||||||||
| Hazard Codes | T,Xn,F | |||||||||
| Risk Statements | 45-36-20/21/22-11-53 | |||||||||
| Safety Statements | 53-36/37/39-45-36-26-16-36/37 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | FZ3675000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| NFPA 704 |
|
3-METHYLCHOLANTHRENE price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 46434 | 3-Methylcholanthrene solution 100?μg/mL in acetonitrile, PESTANAL?, analytical standard | 56-49-5 | 2ML | ₹3830.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 46434 | 3-Methylcholanthrene solution 100?μg/mL in acetonitrile, PESTANAL?, analytical standard | 56-49-5 | 10ML | ₹4974.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 442388 | 3-Methylcholanthrene analytical standard | 56-49-5 | 50MG | ₹7069.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 213942 | 3-Methylcholanthrene 98% | 56-49-5 | 100MG | ₹29653.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 213942 | 3-Methylcholanthrene 98% | 56-49-5 | 250MG | ₹40247.18 | 2022-06-14 | Buy |
3-METHYLCHOLANTHRENE Chemical Properties,Uses,Production
Description
3-Methylcholanthrene (3-MC) is a member of the polycyclic aromatic hydrocarbon (PAH) family and is used as an experimental cancer research chemical. As other PAHs, 3-MC might be found in trace quantities in coal tar and heavy-end petroleum hydrocarbons.
Chemical Properties
3-Methylcholanthrene is a solid that crystallizes from benzene and ether as pale yellow prisms. 3-methylcholanthrene is insoluble in water and soluble in alcohol. It is combustible, and can react with oxidizing materials.
Uses
3-Methylcholanthrene has been used to assess its tumor initiation activity by Bhas 42 cell transformation assay. It has also been used to induce the activity of cytochrome P450.
Definition
ChEBI: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
General Description
Yellow crystals or solid.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
3-METHYLCHOLANTHRENE can react with oxidizing materials. Ozone and chlorinating agents oxidize 3-METHYLCHOLANTHRENE.
Hazard
Powerful carcinogen.
Fire Hazard
Flash point data for 3-METHYLCHOLANTHRENE are not available; however, 3-METHYLCHOLANTHRENE is probably combustible.
Safety Profile
Suspected carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by intravenous and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Potential Exposure
The coke-oven plant is the principal source of coal tar. The hot gases and vapors produced during the conversion of coal to coke are collected by means of a scrubber, which condenses the effluent into ammonia, water, crude tar, and other by-products. Crude tar is separated from the remainder of the condensate for refining and may undergo further processing. Employees may be exposed to pitch and creosote in metal and foundry operations; when installing electrical equipment; in construction, railway, utility; and briquette manufacturing.
Carcinogenicity
3-Methylcholanthrene is a rapid, all-around neoplastic agent and a potent liver tumorigen.
Environmental Fate
3-MC, when released to soil, adsorbs strongly to the soil and does not leach. It does not biodegrade or hydrolyze significantly but may evaporate from dry soil. If released to water, it is expected to adsorb strongly to sediment and to bioconcentrate in aquatic organisms. If released into the atmosphere, it may be subject to direct photolysis because it absorbs strongly in the ultraviolet (UV) spectrum of light. It may also react with peroxyl radicals already present in the atmosphere. Its estimated half-life in the atmosphere is 2.8 h. Considering an octanol/ water log concentration ratio of 6.42, a bioconcentration factor of 45 000 has been estimated.
Shipping
UN1136 Coal tar distillates, flammable, Hazard Class: 3; Labels: 3-Flammable liquid
Incompatibilities
Incompatible with strong oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Phenols, such as creosote react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has pKa = 9.88). These materials are incompatible with strong reducing agents such as hydrides, nitrides, alkali metals, and sulfides. Flammable hydrogen gas is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (e.g., by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid
Waste Disposal
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
3-METHYLCHOLANTHRENE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Inventichem | +918790275459 | Telangana, India | 155 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019 +86-15383190639 | China | 1000 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32835 | 60 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34571 | 58 | Inquiry |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | China | 9640 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | China | 8672 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 50003 | 58 | Inquiry |
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