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ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Methionine derivatives >S-ADENOSYL-L-METHIONINE CHLORIDE SALT

S-ADENOSYL-L-METHIONINE CHLORIDE SALT

S-ADENOSYL-L-METHIONINE CHLORIDE SALT Structure
CAS No.
24346-00-7
Chemical Name:
S-ADENOSYL-L-METHIONINE CHLORIDE SALT
Synonyms
SAM-Cl;SAM CHLORIDE;Einecs 246-184-8;ACTIVE METHIONINE;SAM-E CHLORIDE SALT;ADEMETHIONINECHLORIDE;Active methionine chloride;S-ADENOSYL-L-METHIONINE CHLORIDE;ADENOSYL-L-METHIONINE CHLORIDE, S-;S-ADENOSYL METHIONINE CHLORIDE SALT
CBNumber:
CB4723189
Molecular Formula:
C15H23ClN6O5S
Molecular Weight:
434.9
MOL File:
24346-00-7.mol
MSDS File:
SDS
Modify Date:
2023/5/15 10:43:59
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S-ADENOSYL-L-METHIONINE CHLORIDE SALT Properties

storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility H2O: 100 mg/mL
form Solid
color Off-White to Dark Yellow
Stability Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn
Risk Statements  20/21/22-68/20/21/22
Safety Statements  36-45
WGK Germany  1
F  10-21

S-ADENOSYL-L-METHIONINE CHLORIDE SALT Chemical Properties,Uses,Production

Purification Methods

Purify it by ion exchange on Amberlite IRC-150 and eluting with 0.1-4M HCl. [Stolowitz & Minch J Am Chem Soc 103 6015 1981.] It has been isolated as the tri-reineckate salt by adding 2volumes of 1% solution of ammonium reineckate in 2% perchloric acid. The reineckate salt separates at once but is kept at 2o overnight. The salt is collected on a sintered glass funnel, washed with 0.5% of ammonium reineckate, dried (all operations at 2o) and stored at 2o. To obtain adenosylmethionine, the reineckate is dissolved in a small volume of methyl ethyl ketone (MEK) and centrifuged at room temperature to remove a small amount of solid. The clear dark red supernatant is extracted (in a separating funnel) with a slight excess of 0.1N H2SO4. The aqueous phase is re-extracted with fresh MEK until it is colourless. [Note that reineckates have UV absorption at 305nm ( 15,000), and the optical density at 305nm is used to detect and estimate reineckate ions.] MEK is removed from the aqueous layer containing adenosylmethionine sulfate; the pH is adjusted to 5.6-6.0 and extracted with two volumes of Et2O. The sulfate is obtained by evaporating the aqueous layer in vacuo. The hydrochloride can be obtained in the same way but using HCl instead of H2SO4. SAM-HCl has a solubility of 10% in H2O. The salts are stable in the cold at pH 4-6 but decompose in alkaline media. [Cantoni Biochemical Preparations 5 58 1957.] The purity of SAM can be determined by paper chromatography [Cantoni J Biol Chem 204 403 1953, Methods Enzymol 3 601 1957], electrophoretic methods or enzymic analysis [Cantoni & Vignos J Biol Chem 209 647 1954]. [Beilstein 26 III/IV 3676.]

S-ADENOSYL-L-METHIONINE CHLORIDE SALT Preparation Products And Raw materials

Raw materials

Preparation Products

S-ADENOSYL-L-METHIONINE CHLORIDE SALT Suppliers

Global( 58)Suppliers
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career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26216 58 Inquiry
NewCan Biotech Limited +86-0571-86912261 +8613735419629 China 9980 58 Inquiry
Nextpeptide Inc +86-0571-81612335 +8613336028439 China 19915 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
Young Lively PharminBlock Co.,Ltd +undefined18600731423 China 1944 58 Inquiry
Shanghai Haohong Pharmaceutical Co., Ltd. 4008210725 4008210725 China 55023 58 Inquiry
Sarchem Laboratories, Inc. (732) 938-3777 United States 738 58 Inquiry
Aikon International Limited 025-58859352 18068836627 China 15085 58 Inquiry
Supplier Advantage
career henan chemical co 58
Dideu Industries Group Limited 58
NewCan Biotech Limited 58
Nextpeptide Inc 58
TargetMol Chemicals Inc. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Young Lively PharminBlock Co.,Ltd 58
Shanghai Haohong Pharmaceutical Co., Ltd. 58
Sarchem Laboratories, Inc. 58
Aikon International Limited 58

24346-00-7(S-ADENOSYL-L-METHIONINE CHLORIDE SALT)Related Search:

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SAM CHLORIDE ACTIVE METHIONINE ADENOSYL-L-METHIONINE, S-CHLORIDE SALT S-ADENOSYL-L-METHIONINE CHLORIDE S-ADENOSYL-L-METHIONINE CHLORIDE SALT S-ADENOSYL METHIONINE CHLORIDE SALT S-(5'-ADENOSYL)-L-METHIONINE CHLORIDE (3S)-5'-[(3-amino-3-carboxypropyl)methylsulphonio]-5'-deoxyadenosine chloride S-Adenosyl-5'-L-MethionineChlorideEx ADEMETHIONINECHLORIDE Active methionine, AdoMet, SAM chloride Active methionine chloride S-Adenosyl-5'-L-methionine chloride Einecs 246-184-8 ADENOSYL-L-METHIONINE CHLORIDE, S-(RG) S-(5′-Adenosyl)-L-methionine chloride,Active methionine, AdoMet, SAM chloride 5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-adenosine chloride SAM-E CHLORIDE SALT (2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(methyl)sulfaniumyl)butanoate hydrochloride SAM-Cl S-ADENOSYL-L-METHIONINE CHLORIDE SALT USP/EP/BP ((S)-3-Amino-3-carboxypropyl)(((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonium chloride (2S)-2-amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonio)butanoate hydrochloride ADENOSYL-L-METHIONINE CHLORIDE, S- 24346-00-7 C15H23ClN6O5S C15H23N6O5SCl Enzyme Cofactor BioChemical Cancer Research Chemopreventive Agents Amino Acids & Derivatives Bases & Related Reagents Carbohydrates & Derivatives Nucleotides Sulfur & Selenium Compounds