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DL-METHIONINE METHYLSULFONIUM CHLORIDE

DL-METHIONINE METHYLSULFONIUM CHLORIDE Structure
CAS No.
1115-84-0
Chemical Name:
DL-METHIONINE METHYLSULFONIUM CHLORIDE
Synonyms
MMSC;u-vit;yucron;C04078;cabagin;ardesyl;Vitas U;merastom;epadyn-u;cabaginu
CBNumber:
CB7249996
Molecular Formula:
C6H14ClNO2S
Molecular Weight:
199.7
MOL File:
1115-84-0.mol
MSDS File:
SDS
Modify Date:
2023/10/25 17:25:43

DL-METHIONINE METHYLSULFONIUM CHLORIDE Properties

Melting point 134 °C (decomp)
FEMA 3445 | DL-(3-AMINO-3-CARBOXYPROPYL)DIMETHYLSULFONIUM CHLORIDE
storage temp. Hygroscopic, Refrigerator, Under inert atmosphere
solubility Water (Soluble), Methanol (Slightly)
form Solid
color White to Off-White
Odor at 100.00 %. malty tomato potato sulfury green
Odor Type malty
JECFA Number 1427
Stability Hygroscopic
LogP 0.28
CAS DataBase Reference 1115-84-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319-H335-H315
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Toxicity LD50 oral in rat: > 6gm/kg

DL-METHIONINE METHYLSULFONIUM CHLORIDE Chemical Properties,Uses,Production

Chemical Properties

Naturally occurs as the L-form in a variety of vegetables. Although used in food as a flavoring ingredient in fish products, it has also been used therapeutically in the treatment of peptic ulcers, colitis and gastritis.

Occurrence

Reported found in asparagus, cabbage, cabbage juice, celery, sweet corn, milk, potato, tea, green tea and tomato.

Uses

A derivative of L-Methionine (M260440). Naturally occurring sulfonium compound found in a large number of plants. Identification of antiulcer vitamin in cabbage leaves. Antiulcerative.

Application

Methiosulfonium chloride is used for its protective effect on the liver and gastrointestinal mucosa, whereas the iodide finds use for rheumatic disorders.

Trade name

Chloride: Ardesyl (Beytout, France), withdrawn from the market; Cabagin (Kowa, Japan). Iodide: Lobarthrose (Opodex, France), withdrawn from the market.

Purification Methods

Likely impurities are methionine, methionine sulfoxide and methionine sulfone. Crystallise Vitamin U from water by adding a large excess of EtOH. It is hygroscopic. It should be stored in a cool, dry place and protected from light. It has also been purified on a column of Dowex 50 H+ form, washed with H2O and eluted with 6N ammonia, lyophilised, the residue is dissolved in dilute HCl, lyophilised again and then it is obtained as colourless prisms by vapour diffusion of Et2O in a 1:1 (v/v) mixture of MeOH/EtOH in which the hydrochloride is dissolved [Del Re Acta Cryst B 33 3289 1977]. The iodide salt, m ~ 150o(dec), is obtained by dissolving it in 50% aqueous EtOH and adding ~3.5 volumes of absolute EtOH. The bromide salt has m 140o(dec) [Toennies & Kolb J Amer Chem Soc 67 849 1945].

DL-METHIONINE METHYLSULFONIUM CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(3-amino-3-carboxypropyl)dimethyl-,chloride,(s)-sulfoniu (3-amino-3-carboxypropyl)dimethyl-,chloride,l-sulfoniu (3-amino-3-carboxypropyl)dimethyl-,chloride,L-Sulfonium VITAMIN U VITAMIN U CHLORIDE ardesyl cabagin cabaginu epadyn-u merastom methylmethioninesulfoniumchloride s-methymethioninechloride u-vit yucron S-methylmethioninium chloride (S)-(3-Amino-3-carboxypropyl)dimethyl sulfonium chloride L-MethionineS-methylsulfoniumchloride Methylmethionine Sulfonium, (3S)-3-amino-3-carboxypropyldimethyl-, chloride METHIOSULFONIUMCHLORIDE S-METHYLMETHIONINESULFONIUM CHLORIDE S-METHYL-DL-METHIONINE-SULFONIUMCHLORIDE (3-AMINO-3-CARBOXYPROPYL)DIMETHYLSULFONIUM CHLORIDE DL-METHIONINE METHYLSULFONIUM CHLORIDE DL-METHYLMETHIONINE SULFONIUMCHLORIDE DL-(3-AMINO-3-CARBOXYPROPYL)DIMETHYLSULFONIUM CHLORIDE METHYL-METHIONINE SULPHONIUM CHLORIDE DL-(3-AMINO-3-CARBOXYPROPYL)DIMETHYLSULPHONIUMCHLORIDE Vitamin U,chlorine type L-Methionine methylsulfonium chloride VITAMIN U (USP) (S-METHYLMETHIONINESULFONIUM CHLORIDE) [(3S)-3-AMino-3-carboxypropyl](diMethyl)sulfoniuM Chloride L-(3-AMino-3-carboxypropyl)(diMethyl)sulfoniuM Chloride MMSC S-MethylMethionine Chloride Vitas U L-Methylmethionine sulfonium chloride Methionine methylsulfonium chloride C04078 Methylmethionine sulfonium salt [(3S)-3-amino-3-carboxypropyl]-dimethylsulfanium:chloride Pardoprunox Impurity 26 1115-84-0 115-84-0 C6H14NO2SCl C6H16ClNO2S Modified Amino Acids I - Z Sulfonium Compounds Iodonium Sulfonium & Oxonium Compounds BioChemical Amino Acids and Peptides Biochemicals and Reagents Vitamins and derivatives Amino Acids & Derivatives Sulfur & Selenium Compounds