Epiandrosterone
- CAS No.
- 481-29-8
- Chemical Name:
- Epiandrosterone
- Synonyms
- TRANS-ANDROSTERONE;ISOANDROSTERONE;5ALPHA-ANDROSTAN-3BETA-OL-17-ONE;EpiA;3-Hydroxyandrostan-17-one;Androstan-17-one, 3-hydroxy-, (3b,5a)-;NSC 93996;epirosterone;3b-Androsterone;3β-Androsterone
- CBNumber:
- CB4725653
- Molecular Formula:
- C19H30O2
- Molecular Weight:
- 290.45
- MOL File:
- 481-29-8.mol
- Modify Date:
- 2024/7/2 8:55:09
| Melting point | 172-174 °C |
|---|---|
| alpha | 91 º (c=1, CH3OH) |
| Boiling point | 372.52°C (rough estimate) |
| Density | 1.0320 (rough estimate) |
| refractive index | 1.4709 (estimate) |
| storage temp. | Refrigerator |
| solubility | insoluble in H2O; ≥12.35 mg/mL in EtOH; ≥28.27 mg/mL in DMSO |
| form | solid |
| pka | 15.14±0.60(Predicted) |
| color | White to off-white |
| Water Solubility | practically insoluble |
| Merck | 3609 |
| BRN | 1884007 |
| InChIKey | QGXBDMJGAMFCBF-LUJOEAJASA-N |
| LogP | 3.751 |
| CAS DataBase Reference | 481-29-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 3Beta-hydroxy-5alpha-androstan-17-one(481-29-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361fd |
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| F | 21 |
| HS Code | 29144000 |
Epiandrosterone price More Price(2)
Epiandrosterone Chemical Properties,Uses,Production
Description
Epiandrosterone is a steroid hormone with weak androgenic activity, derived from 5 α-androstane. It is a dehydroepiandrosterone metabolite and an androgen. It is a precursor of testosterone and estradiol with hypolipidemic and anabolic activities.
Chemical Properties
white to off-white crystalline powder. Musky odor when heated.
Uses
Epiandrosterone is used for weight loss, to improve athletic performance, to reduce sexual problems, and for many other uses, but there is no good scientific evidence to support its use. Epiandrosterone might also be unsafe.
Epiandrosterone is a steroid hormone that is present in normal human urine as a minor constituent , it is a less active 3β-isomer of the androgen Androsterone (A635535). Controlled Substance.
Definition
ChEBI: Epiandrosterone is a 3beta-hydroxy steroid that is (5alpha)-androstane substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It has a role as an androgen and a human metabolite. It is a 17-oxo steroid, a 3beta-hydroxy steroid and an androstanoid. It derives from a 5alpha-androstane.
Purification Methods
Purify epi-androsterone via the acetate, hydrolyse this and recrystallise it from CHCl3/hexane or aqueous EtOH. The acetate [1239-31-2] is purified by chromatography and when crystallised from pet ether has m 103-104o, []D +68.5o (c 1, CHCl3). The oxime has m 194-196o (from MeOH), []D +17.5o (c 6.2, CHCl3). The racemic ketone is sublimed at 130o/high vacuum and after two crystallisations from methylcyclohexane it gives prisms with m 161-162o (which changed crystal form at 140-145o). [Ruzicka & Wettstein Helv Chim Acta 18 1264 1935, Johnson et al. J Am Chem Soc 75 2275 1953, 78 6331 1956, Cordwell et al. J Chem. Soc 361 1953, Beilstein 8 IV 462.]
Epiandrosterone Preparation Products And Raw materials
Raw materials
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