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Cephaloridine

Cephaloridine Structure
CAS No.
50-59-9
Chemical Name:
Cephaloridine
Synonyms
Sefacin;Ceporin;Ceporan;Ceflorin;Keflodin;Keflordin;Sch 11527;Cephaloridine;Cephaloridine II;Cephaloridine USP/EP/BP
CBNumber:
CB4875354
Molecular Formula:
C19H17N3O4S2
Molecular Weight:
415.48
MOL File:
50-59-9.mol
MSDS File:
SDS
Modify Date:
2024/8/28 13:53:23
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Cephaloridine Properties

Melting point 184°C
alpha D +47.7° (c = 1.25 in water)
Density 1.3230 (rough estimate)
refractive index 1.6390 (estimate)
storage temp. 2-8°C
pka 3.2(at 25℃)
optical activity +47.720 (c 1.25, H2O)
Water Solubility >20g/L(21 ºC)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H317
Precautionary statements  P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
Hazard Codes  Xn
Risk Statements  42/43
Safety Statements  22-36/37-45
Hazardous Substances Data 50-59-9(Hazardous Substances Data)
Toxicity LD50 mice, rats (g/kg): >15, 2.5-4 orally; in monkeys (g/kg): >0.2 i.m. (Atkinson)

Cephaloridine Chemical Properties,Uses,Production

Uses

Antibacterial agent.

Definition

ChEBI: A cephalosporin compound having pyridinium-1-ylmethyl and 2-thienylacetamido side-groups. A first-generation semisynthetic derivative of cephalosporin C.

World Health Organization (WHO)

Cefaloridine, a semi-synthetic cephalosporin antibiotic, was introduced into medicine in 1964 for the treatment of bacterial infections. It is considered to be the most toxic of the cephalosporins, and for this reason is now seldom used. Nevertheless, it still remains available in certain countries and the World Health Organization is not aware of restrictive actions taken elsewhere.

General Description

Cephaloridine, along with cephalothin, was the first member of the synthetic cephalosporin C class of antibiotic, to be introduced clinically. It was synthesized, starting with 7-aminocephalosporanic acid, by Glaxo Research Laboratories in 1962. This drug shows strong activity against gram-positive and gramnegative bacteria and Leptospira, including benzylpenicillin-resistant strains. It has been given widely by intravenous, intramuscular, and intraspinal injection to treat a variety of infections caused by Staphylococcus, Streptococcus, Neisseria, Klebsiella, Escherichia coli, and other pathogens. Because of its renal toxicity and the development of newer and more active synthetic cephalosporins, its use is declining.

Hazard

Moderately to very toxic.

Cephaloridine Preparation Products And Raw materials

Raw materials

Pyridine 7-Aminocephalosporanic acid 2-Thiopheneacetyl chloride 2-Thiopheneacetic acid

Preparation Products

4-Epoxypropanoxycarbazole Propylamine

Cephaloridine Suppliers

Global( 24)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6739 58 Inquiry
Central Drug House(P) Ltd. 91-11-49404040 New Delhi, India 6157 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6754 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32161 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. +86-0551-65418671 +8618949823763 China 34563 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22787 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15352 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. 571-88938639 +8617705817739 China 52849 58 Inquiry
GIHI CHEMICALS CO.,LIMITED +8618058761490 China 49977 58 Inquiry
Zhejiang Huida Biotech Co., LTD 0571-0571-89903882 15990081639 China 3705 58 Inquiry
Supplier Advantage
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Central Drug House(P) Ltd. 58
Pharma Affiliates 58
TargetMol Chemicals Inc. 58
Hefei TNJ Chemical Industry Co.,Ltd. 58
Dideu Industries Group Limited 58
AFINE CHEMICALS LIMITED 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
GIHI CHEMICALS CO.,LIMITED 58
Zhejiang Huida Biotech Co., LTD 58

Cephaloridine Spectrum

Cephaloridine(50-59-9)MSCephaloridine(50-59-9)1HNMRCephaloridine(50-59-9)13CNMRCephaloridine(50-59-9)IR1Cephaloridine(50-59-9)IR2

50-59-9(Cephaloridine)Related Search:

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Cephaloridine Ceflorin Ceporan N-[7-[2'-Thienyl-acetamidoceph-3-ylmethyl]] pyridinium-4-carboxylate pyridinium, 1-((2-carboxy-8-oxo-7-(2-(2-thienyl)acetamido)-5-thia-1-azabicyclo( 4.2.0)o ct- 2-en-3-yl)methyl)-, hydroxide, inner salt 1-[(7'-beta-[2-(2-thienyl)acetamido]-8'-oxo-1'-aza-5'-t hiabicyclo[4.2.0]-oct-2 '-en-3'-yl)methyl]pyridinium-2'-carboxylate 40602 7-((2-thienyl)acetamido)-3-(1-pyridylmethyl)cephalosporanic acid 7-(alpha-(2-thienyl)acetamido)-3-(1-pyridylmethyl)-3-cephem-4-carboxylic acid 7-(alpha-(2-thienyl)acetamido)-3-(1-pyridylmethyl)-3-cephem-4-carboxylic acid b etaine (6R,7R)-8-oxo-3-(pyridin-1-ylmethyl)-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Ceporin Keflodin Keflordin Sefacin (6R,7R)-8-Oxo-3-(1-pyridiniumylmethyl)-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate PyridiniuM,1-[[(6R,7R)-2-carboxy-8-oxo-7-[[2-(2-thienyl)acetyl]aMino]-5-thia-1-azabicyclo[4.2.0]oct- N-(7-[2′-Thienylacetamidoceph-3-ylmethyl])pyridinium 2-carboxylate (6R,7R)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Cephaloridine II CEFALORIDINE (ALPHA FORM) USP/EP/BP Cephaloridine USP/EP/BP Sch 11527 Enavogliflozin Impurity 32 50-59-9 C19H17N3O4S4 C19H17N3O4S2 C19H18N3O4S2