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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >GPCR & G Protein >Cannabinoid Receptor agonists >(R,S)-AM1241

(R,S)-AM1241

(R,S)-AM1241 Structure
CAS No.
444912-48-5
Chemical Name:
(R,S)-AM1241
Synonyms
Methanone, (2-iodo-5-nitrophenyl)[1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl]-;(R,S)-AM1241;AM1241 (AM-1241;(R,S)-AM1241 USP/EP/BP;(R,S)-3-(2-Iodo-5-nitrobenzoyl)-1-(1-methyl-2-piperidinylmethyl)-1H-indole;(3-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone;(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone;(2-Iodo-5-nitrophenyl)[1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl]methanone;(2-Iodo-5-nitrophenyl)(1-((1-methylpiperidin-2-yl)methyl)-1H-Indol-3-yl)methanone
CBNumber:
CB4972473
Molecular Formula:
C22H22IN3O3
Molecular Weight:
503.33
MOL File:
444912-48-5.mol
Modify Date:
2023/6/8 9:01:57
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(R,S)-AM1241 Properties

Boiling point 630.7±55.0 °C(Predicted)
Density 1.60±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: ~18mg/mL at 60°C
pka 9.73±0.10(Predicted)
form solid
color yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08
Signal word  Danger
Hazard statements  H315-H319-H334-H335
Precautionary statements  P302+P352-P305+P351+P338
Hazard Codes  Xn
Risk Statements  36/37/38-42/43
Safety Statements  22-26-36/37-45
WGK Germany  3
NFPA 704
0
2 0

(R,S)-AM1241 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) A6478 (R,S)-AM1241 ≥98% (HPLC), solid 444912-48-5 5MG ₹24832.55 2022-06-14 Buy
Sigma-Aldrich(India) A6478 (R,S)-AM1241 ≥98% (HPLC), solid 444912-48-5 25MG ₹111703.18 2022-06-14 Buy
Product number Packaging Price Buy
A6478 5MG ₹24832.55 Buy
A6478 25MG ₹111703.18 Buy

(R,S)-AM1241 Chemical Properties,Uses,Production

Description

AM1241 is a cannabinoid (CB) receptor agonist that is selective for CB2 over CB1 with Ki values of 7.1 and 580 nM for human recombinant receptors transfected into HEK and CHO cells, respectively, in a radioligand binding assay. It is considered a protean agonist as it has neutral antagonist and partial agonist activity, depending on the assay utilized. It is also acts in a species-dependent manner in vitro, acting as an agonist at human CB2 receptors (EC50 = 190 nM) but an inverse agonist at rat and mouse CB2 receptors (EC50s = 216 and 463 nM, respectively). AM1241 produces antinociception to thermal stimuli in rat hindpaw. The antinociceptive actions of AM1241 were blocked by the CB2 receptor-selective antagonist AM630 but not by the CB1 receptor-selective antagonist AM251 . AM1241 is neuroprotective, preventing HIV-1 glycoprotein Gp120-induced apoptosis in primary human and murine neural progenitor cells and increasing cell survival and differentiation. It increases hippocampal neurogenesis and decreases astro- and gliogenesis in GFAP/Gp120 transgenic mice when administered at a dose of 10 mg/kg daily for ten days. AM1241 also delays motor impairment in a murine model of amytrophic lateral sclerosis (ALS).

Uses

(2-Iodo-5-nitrophenyl)[1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl]methanone is a compound from the aminkalkylindole family which exerts potent and selective agonist activity for the cannabinoid receptor CB2.

Biochem/physiol Actions

AM1241 acts as an antinociceptive agent in several animal pain models. It has a potential to delay disease progression in amyotrophic lateral sclerosis (ALS) mouse model. Intrathecal, intravenous or intraperitoneal administration of AM1241 reduces hyperalgesia and allodynia in neuropathic rats.

(R,S)-AM1241 Preparation Products And Raw materials

Raw materials

Preparation Products

(R,S)-AM1241 Suppliers

Global( 54)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 24664 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd. 15800340161 CHINA 6846 58 Inquiry
Wuhan Yanzhe Technology Co., Ltd 15527250409 China 4577 58 Inquiry
Supplier Advantage
CHEMSWORTH 30
ATK CHEMICAL COMPANY LIMITED 60
CONIER CHEM AND PHARMA LIMITED 58
Dideu Industries Group Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
Shanghai Hao Zhun Biological Technology Co., Ltd. 58
Wuhan Yanzhe Technology Co., Ltd 58

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(R,S)-AM1241 (R,S)-3-(2-Iodo-5-nitrobenzoyl)-1-(1-methyl-2-piperidinylmethyl)-1H-indole (3-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone (2-Iodo-5-nitrophenyl)(1-((1-methylpiperidin-2-yl)methyl)-1H-Indol-3-yl)methanone (2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone (2-Iodo-5-nitrophenyl)[1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl]methanone AM1241 (AM-1241 (R,S)-AM1241 USP/EP/BP Methanone, (2-iodo-5-nitrophenyl)[1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl]- 444912-48-5 C22H22IN3O3