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Aprepitant

CAS No.: 170729-80-3

Chemical Name:: Aprepitant

Synonyms: 3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one;Emend;Aprepitan;5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one;CS-274;MK-0869;ONO 7436;aprepitant;Aprepirant;Fushapitan

CBNumber:: CB7500857

Molecular Formula:: C23H21F7N4O3

Molecular Weight:: 534.43

MOL File:: 170729-80-3.mol

Modify Date:: 2024/10/31 18:15:48

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Aprepitant Properties

Melting point	244-246°C
alpha	D25 +69° (c = 1.00 in methanol)
Density	1.51±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	Soluble in DMSO (>25 mg/ml)
pka	8.06±0.20(Predicted)
form	powder
color	white to beige
optical activity	[α]/D +61 to +71°, c = 1.0 in methanol
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference	170729-80-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Warning

Hazard statements

H319-H351

Precautionary statements

P501-P202-P201-P264-P280-P308+P313-P337+P313-P305+P351+P338-P405

HS Code

2934990002

NFPA 704

	0
2		0

Aprepitant price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML2215	Aprepitant ≥98% (HPLC)	170729-80-3	5MG	₹9331.15	2022-06-14	Buy
Sigma-Aldrich(India)	SML2215	Aprepitant ≥98% (HPLC)	170729-80-3	25MG	₹20112.85	2022-06-14	Buy
TCI Chemicals (India)	A3135	Aprepitant	170729-80-3	100MG	₹8000	2022-05-26	Buy
TCI Chemicals (India)	A3135	Aprepitant	170729-80-3	500MG	₹15000	2022-05-26	Buy

Product number	Packaging	Price	Buy
SML2215	5MG	₹9331.15	Buy
SML2215	25MG	₹20112.85	Buy
A3135	100MG	₹8000	Buy
A3135	500MG	₹15000	Buy

Aprepitant Chemical Properties,Uses,Production

Description

Aprepitant is an antiemetic chemical compound that belongs to “substance P” antagonists (SPA) with its effect being blocking the neurokinin 1(Nk1) receptor. It is used for the prevention of acute and delayedchemotherapy-induced nausea and vomiting(CINV) and for prevention ofpostoperative nausea and vomiting. It can also be used for the treatment of cyclic vomiting syndrome and late-stage chemotherapy induced vomiting occurring during cancer treatment. Aprepitant alleviates the case of vomiting in patients through balking the signals released by Nk1 receptors. Nk1 is a G-protein-coupled receptor with its ligand being substance P (SP). The high concentration of SP is required for the vomiting reflex. Aprepitant blocks the process of SP-NK1 signaling in activating the vomiting reflex.

Chemical Properties

Off-White to Light Yellow Cyrstalline Solid

Uses

A novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.

Definition

ChEBI: A morpholine-based antiemetic, which is or the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/ eurokinin 1 (NK1) receptors.

References

Curran, Monique P., and D. M. Robinson. "Aprepitant."Drugs69.13(2009):1853-1878.
Sant P. Chawla M.D. † ‡, et al. "Establishing the dose of the oral NK 1, antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting." Cancer 97.9(2003):2290-2300.
Warr, D. G., et al. "Efficacy and tolerability of aprepitant for the prevention of chemotherapy-induced nausea and vomiting in patients with breast cancer after moderately emetogenic chemotherapy." Journal of Clinical Oncology Official Journal of the American Society of Clinical Oncology23.12(2005):2822-30.
https://en.wikipedia.org/wiki/Aprepitant

Aprepitant Preparation Products And Raw materials

Raw materials

Aprepitant Impurity 9

Preparation Products

Aprepitant Suppliers

Global( 616)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
ANWITA APIS	+919000311012	Hyderabad, India	195	58	Inquiry
Varanous Labs Pvt Ltd	+91-7036248882 +91-7036248882	Hyderabad, India	1537	58	Inquiry
USV Pvt Ltd	+91-2267861111 +91-2225564048	Maharashtra, India	36	58	Inquiry
Piramal Pharma Solutions	+919892735994	Maharashtra, India	48	58	Inquiry
Glenmark Pharmaceuticals Limited	+912240189999	Maharashtra, India	93	58	Inquiry
Hetero Drugs Limited	+91-4023704923 +91-4023704923	Telangana, India	296	58	Inquiry
Everest Organics Limited	+91-4040028838 +91-9440409996	Hyderabad, India	61	58	Inquiry
Nosch Labs Pvt Ltd	+91-4048557474 +91-9948222287	Hyderabad, India	58	58	Inquiry
Mehta API Pvt. Ltd.	+91-9920552082 +91-9920552082	Maharashtra, India	33	58	Inquiry
Solara Active Pharma Sciences Ltd	+91-8046632100 +91-7075706520	Bangalore, India	65	58	Inquiry

Supplier	Advantage
ANWITA APIS	58
Varanous Labs Pvt Ltd	58
USV Pvt Ltd	58
Piramal Pharma Solutions	58
Glenmark Pharmaceuticals Limited	58
Hetero Drugs Limited	58
Everest Organics Limited	58
Nosch Labs Pvt Ltd	58
Mehta API Pvt. Ltd.	58
Solara Active Pharma Sciences Ltd	58

Aprepitant Spectrum

Aprepitant(170729-80-3)¹HNMR

170729-80-3(Aprepitant)Related Search:

Methyltriphenylphosphonium bromide Dichloromethylphenylsilane Dimethomorph Ethoxymethylenemalononitrile PHENYL VALERATE

Moroxydine Diphenyl ether Moroxydine hydrochloride Aprepitant iMpurity A PHENYL RESIN

Phenylacetic acid Aprepitant-d4 (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol (S)-3-phenylmorpholine 2-(R)-[1-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(S)-fluorophenylmorpholine[Aprepitant-M2]

1,2-Dihydro-3H-1,2,4-triazol-3-one (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine hydrochloride Aprepitant 13C2, D2 (Major)

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MK-0869 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1, 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one, Emend Aprepitant(MK-0869) ONO 7436 5-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholino)Methyl)-1H-1,2,4-triazol-3(2H)-one Aprepirant aprepitant 5-[2(R)-[1(R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-ylmethyl]-3,4-dihydro-2H-1,2,4-triazol-3-one MK0869 Aprepitant mk 0869 Aprepitant Aprepitant, >=99% 3-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)meth 3-(((2R,3S)-2-((R)-1 -(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl)morpholino)methyl)- 1H-1,2,4-triazol-5(4H)-one (Aprepitant) 5-[2(r)-[1(r)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(s)-(4-fluorophenyl)morpholin-4-ylmethyl]-3,4-dihydro-2h-1,2,4-triazol-3-one CS-274 Aprepitant (MK-0869, L-754030) Fosaprepitant Impurity 8(Aprepitant) Fushapitan Aprepitant CRS (1R,2R,3S)-Aprepitant Aprepitant USP/EP/BP 5-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one Aprepitant (Y0001825) AprepitantQ: What is Aprepitant Q: What is the CAS Number of Aprepitant Q: What is the storage condition of Aprepitant Q: What are the applications of Aprepitant Aprepitant (1041904) tetrapotassium salt 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one Emend 3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one Aprepitan His minions pyrazole temple c . (6a R)-9-[7,8-d i d e h yd ro-4,5α-e poxy-3-h yd roxy-17-me th ylmorph i na n-6α-yl]-6-me th yl-5,6,6a ,7-te tra h yd ro-4h -d i b e nzo[d e ,g ]qui noli ne -10,11-d i ol (morph i ne -a pomorph i ne d i me r). 5-[2(R)-[1(R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-ylmethyl]-3,4-dihydro-2H-1,2,4-triazol-3-one 5-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-2,3-dihydro-1H-1,2,4-triazol-3-one 170729-80-3 C23H21F7N4O3 Inhibitors Aprepitant Pharmaceutical intermediate Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals API 170729-80-3