LEVCROMAKALIM

CAS No.: 94535-50-9

Chemical Name:: LEVCROMAKALIM

Synonyms: brl38227;lemakalim;Brn 3622889;levcromakelim;LEVCROMAKALIM;LevkroMakaliM;(3s-trans)-yrrolidinyl);Potassium Channel,KcsA,Inhibitor,inhibit,BRL38227,BRL-38227,Levcromakalim;(3β,4α)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile;(3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile

CBNumber:: CB5104507

Molecular Formula:: C16H18N2O3

Molecular Weight:: 286.33

MOL File:: 94535-50-9.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:09

Request For Quotation

LEVCROMAKALIM Properties

Melting point	242-244°
alpha	D26 -52.2° (c = 1 in chloroform)
Boiling point	482.3±45.0 °C(Predicted)
Density	1.31±0.1 g/cm3(Predicted)
storage temp.	Store at RT
solubility	DMSO: ≤10 mM, soluble
pka	13.18±0.60(Predicted)
form	solid
color	White to off-white

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3
RTECS	DJ2177500

LEVCROMAKALIM Chemical Properties,Uses,Production

Uses

Levcromakalim is a potassium channel activator and vasorelaxant used in the management of hypertension in diabetes mellitus.

Biological Activity

Active enantiomer of the prototypical K ATP channel opener cromakalim (trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile ). Hypotensive and airways relaxant. IC 50 = 490 nM in guinea pig trachea.

LEVCROMAKALIM Preparation Products And Raw materials

Raw materials

Preparation Products

LEVCROMAKALIM Suppliers

Global( 52)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9338	55	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	China	49739	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
RD International Technology Co., Limited	18024082417	China	9155	58	Inquiry
Suzhou Zhixin Biotechnology Co., Ltd.	0512-65118909 15162312715	China	2992	58	Inquiry
Changzhou PBpharmaceutical R&D Co.,Ltd	0519-83990708	China	480	55	Inquiry
Aikon International Limited	025-66113011 18112977050	China	15495	58	Inquiry
cjbscvictory	13348960310 13348960310	China	10011	58	Inquiry
TargetMol Chemicals Inc.	4008200310	China	24017	58	Inquiry

Supplier	Advantage
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Aladdin Scientific	58
RD International Technology Co., Limited	58
Suzhou Zhixin Biotechnology Co., Ltd.	58
Changzhou PBpharmaceutical R&D Co.,Ltd	55
Aikon International Limited	58
cjbscvictory	58
TargetMol Chemicals Inc.	58

LEVCROMAKALIM Spectrum

LEVCROMAKALIM(94535-50-9)¹HNMR

94535-50-9(LEVCROMAKALIM)Related Search:

4-TERT-BUTOXYBENZONITRILE 3-(methylaminomethyl)benzonitrile LEVCROMAKALIM 3-M-TOLYL-DL-BETA-ALANINOL 3-CYANOBENZYLAMINE

(S)-3-Dimethylamino-3-phenylpropanol 1-Benzyl-2-pyrrolidinone CROMAKALIM (S)-3-(1-Aminoethyl)benzonitrile 4-(2-hydroxyethoxy)benzonitrile

2-(3-CYANO-PHENYL)ETHANOL (2S)-(-)-1-AMINO-3-PHENOXY-2-PROPANOL 4-isopropoxybenzonitrile 1-(3-HYDROXYPROPYL)-2-PYRROLIDONE 3-PYRROLIDINO-1,2-PROPANEDIOL

1-(3-METHOXYPROPYL)-2-PYRROLIDINONE 6-METHYL-CHROMAN-4-YLAMINE HYDROCHLORIDE 4-[3-(Dimethylamino)propoxy]benzonitrile

chevron_left

1of4

chevron_right

(3S,4R)-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-4-(2-OXO-1-PYRROLIDINYL)-2H-1-BENZOPYRAN-6-CARBONITRILE (3s-trans)-yrrolidinyl) LEVCROMAKALIM 2h-1-benzopyran-6-carbonitrile,3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-p brl38227 lemakalim levcromakelim (3S,4R)-3β-Hydroxy-4-(2-oxopyrrolizino)-2,2-dimethyl-3,4-dihydro-6-cyano-2H-1-benzopyran (3β,4α)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-6-carbonitrile (3β,4α)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3S,trans)- Brn 3622889 LevkroMakaliM (3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3S,4R)- Potassium Channel,KcsA,Inhibitor,inhibit,BRL38227,BRL-38227,Levcromakalim 94535-50-9 Ion Channels Monovalent Ion Channels Potassium Channel Modulators Voltage-gated Ion Channels Cell Signaling and Neuroscience Cell Biology BioChemical