CROMAKALIM

CAS No.: 94470-67-4

Chemical Name:: CROMAKALIM

Synonyms: BRL-34915;CROMAKALIM;AKOS 91890;(+/-)-CROMAKALIM;Cromakalim=([+/-]-trans-6-Cyano-3,4-dihydro-2,2-;rac-(3α*,4β*)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidine-1-yl)chroman-6-carbonitrile;(-trans-6-Cyano-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-3,4-dihydro-2H-benzo[b]pyran-3-ol;(3S)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile;[+/-]-TRANS-6-CYANO-3,4-DIHYDRO-2,2-DIMETHYL-4-[2-OXOPYRROLIDIN-1-YL]-2H-1-BENZOPYRAN-3-OL;(+/-)-TRANS-6-CYANO-3,4-DIHYDRO-2,2-DIMETHYL-4-(2-OXOPYRROLIDIN-1-YL)-2H-1-BENZOPYRAN-3-OL

CBNumber:: CB7771686

Molecular Formula:: C16H18N2O3

Molecular Weight:: 286.33

MOL File:: 94470-67-4.mol

Modify Date:: 2023/5/18 11:31:08

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CROMAKALIM Properties

Melting point	242-244°C
storage temp.	2-8°C
solubility	Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).
form	solid
color	Off-white
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3

CROMAKALIM price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	C1055	Cromakalim	94470-67-4	10MG	₹18824.68	2022-06-14	Buy
Sigma-Aldrich(India)	C1055	Cromakalim	94470-67-4	50MG	₹75179.63	2022-06-14	Buy

Product number	Packaging	Price	Buy
C1055	10MG	₹18824.68	Buy
C1055	50MG	₹75179.63	Buy

CROMAKALIM Chemical Properties,Uses,Production

Description

(±)-Cromakalim is a prototypical activator of the ATP-sensitive potassium channel, SUR2-K_ir6, that displays anti-ischemic (EC₂₅ = 8.9 μM) and cardioprotective (IC₅₀ = 0.03 μM) effects in rat hearts. (±)-Cromakalim has also been shown to relax bladder smooth muscle in vitro. It has been used to investigate potassium channel biology and as a scaffold to develop increasingly selective K⁺ channel openers with clinical relevance.

Chemical Properties

White Crystalline Solid

Uses

Cromakalim causes vasodilation by activation of potassim channels

Biological Activity

Prototypical K ATP channel opener. Relaxes rabbit isolated portal vein with an IC 50 value of 21 nM . Potent, orally active and hypotensive in vivo .

CROMAKALIM Preparation Products And Raw materials

Raw materials

Preparation Products

CROMAKALIM Suppliers

Global( 36)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
RD International Technology Co., Limited	18024082417	China	9268	58	Inquiry
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	China	9806	58	Inquiry
TargetMol Chemicals Inc.	4008200310	China	24648	58	Inquiry
Suzhou Zhixin Biotechnology Co., Ltd.	0512-65118909 15162312715	China	2993	58	Inquiry
Cayman Chemical Company	(800) 364-9897	United States	6618	81	Inquiry
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	China	4738	58	Inquiry
Focus Biomolecules	855-362-8721	United States	1284	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
RD International Technology Co., Limited	58
Shanghai EFE Biological Technology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Suzhou Zhixin Biotechnology Co., Ltd.	58
Cayman Chemical Company	81
Nantong QuanYi Biotechnology Co., Ltd	58
Focus Biomolecules	58

94470-67-4(CROMAKALIM)Related Search:

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4-TERT-BUTOXYBENZONITRILE (R)-3-(1-aminoethyl)benzonitrile (S)-3-Amino-3-phenylpropan-1-ol LEVCROMAKALIM (S)-1-(2-Methoxyphenyl)ethylamine

3-CYANOBENZYLAMINE CROMAKALIM CHROMAN-4-YLAMINE (S)-3-Dimethylamino-3-phenylpropanol 3-(Diethylamino)-1,2-propanediol

N-(2-Hydroxyethyl)-2-pyrrolidone 1-(3-HYDROXYPROPYL)-2-PYRROLIDONE 4-isopropoxybenzonitrile

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Cromakalim=([+/-]-trans-6-Cyano-3,4-dihydro-2,2- (+/-)-CROMAKALIM CROMAKALIM TRANS-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-4-(2-OXO-1-PYRROLIDINYL)-2H-1-BENZOPYRAN-6-CARBONITRILE (+/-)-TRANS-6-CYANO-3,4-DIHYDRO-2,2-DIMETHYL-4-(2-OXOPYRROLIDIN-1-YL)-2H-1-BENZOPYRAN-3-OL [+/-]-TRANS-6-CYANO-3,4-DIHYDRO-2,2-DIMETHYL-4-[2-OXOPYRROLIDIN-1-YL]-2H-1-BENZOPYRAN-3-OL BRL-34915 rac-(3α*,4β*)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidine-1-yl)-2H-1-benzopyran-6-carbonitrile rac-(3α*,4β*)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidine-1-yl)chroman-6-carbonitrile rac-3,4-Dihydro-3α*-hydroxy-2,2-dimethyl-4β*-(2-oxopyrrolidine-1-yl)-2H-1-benzopyran-6-carbonitrile (3R,4S)-rel-3,4-Dihydro-3-hydroxy-2,2-diMethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile (-trans-6-Cyano-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-3,4-dihydro-2H-benzo[b]pyran-3-ol AKOS 91890 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3R,4S)-rel- (3S)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile 94470-67-4 Monovalent Ion Channels Ion Channels Voltage-gated Ion Channels Potassium Channel Modulators BioChemical Cell Biology Cell Signaling and Neuroscience All Inhibitors Inhibitors