Azamulin
- CAS No.
- 76530-44-4
- Chemical Name:
- Azamulin
- Synonyms
- Azamulin; SA 85530b;TMD 85-530, SA 85530b;Antibiotic TDM 85-530;14-O-(5-(2-Amino1,3,4-triazolyl)thioacetyl)dihydromutilin;[(5-Amino-1H-1,2,4-triazol-3-yl)thio]acetic acid (3aS,4R,5S,6R,8R,9R,9aR,10R)-6-ethyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester;Acetic acid, 2-[(3-amino-1H-1,2,4-triazol-5-yl)thio]-, (3aS,4R,5S,6R,8R,9R,9aR,10R)-6-ethyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
- CBNumber:
- CB51176138
- Molecular Formula:
- C24H38N4O4S
- Molecular Weight:
- 478.65
- MOL File:
- 76530-44-4.mol
- Modify Date:
- 2023/6/8 9:02:31
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
Azamulin price More Price(2)
Azamulin Chemical Properties,Uses,Production
Description
Azamulin is a selective, irreversible inhibitor of cytochrome P450 (CYP) 3A isoforms (IC50 values range from 26 to 240 nM for CYP3A4 and CYP3A4/5 from different sources). It is at least 50-fold less potent against CYP2J2 and 100-fold less effective against all other CYP isoforms. Azamulin potently blocks the hydroxylation of testosterone and midazolam by CYP3A4.
Chemical Properties
White Solid
Uses
Azamulin is a semi-synthetic pleuromutilin prepared by sequential reaction of dihydropleuromutilin tosylate with 2-amino-1,2,4-triazole-5-thiol. While azamulin is a broad spectrum antibiotic in the pleuromutilin class, this aspect of its bioprofile has received little attention. In fact, the triazole substituent added to nominally improve the drugs bioavailability, imparted an unusual selectivity for the inhibition of specific cytochrome P450 mixed function oxidase sub-types, important for understanding the manner in which the body metabolises drugs or xenobiotics.
General Description
Azamulin isolated from fungus Pleurotus mutilis is a diterpene antibiotic. It is related to pleuromutilin being its synthetic azole derivative.
Azamulin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6754 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29810 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19741 | 58 | Inquiry |
| Shanghai Saikerui Biotechnology Co. , Ltd. | 021-58000709 15900491054 | China | 10329 | 58 | Inquiry |
| TLC Pharmaceutical Standards Ltd. | 18012923235 | China | 4921 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6213 | 81 | Inquiry |
| Beijing Lebo Biotechnology Co., Ltd. | 010-50934026 | CHINA | 6057 | 58 | Inquiry |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | China | 8140 | 58 | Inquiry |
| Lanospharma Laboratories Co.,Ltd | 13440048448 | China | 6329 | 56 | Inquiry |