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PROADIFEN HYDROCHLORIDE

PROADIFEN HYDROCHLORIDE Structure
CAS No.
62-68-0
Chemical Name:
PROADIFEN HYDROCHLORIDE
Synonyms
skf525a;PROADIFEN;SKF-525A, HYDROCHLORIDE;5171rp;U 5446;SKF 525;SU-5446;nsc39690;SKF-525A HCL;PROADIFEN, HCL
CBNumber:
CB5120727
Molecular Formula:
C23H32ClNO2
Molecular Weight:
389.96
MOL File:
62-68-0.mol
Modify Date:
2025/1/27 9:38:02

PROADIFEN HYDROCHLORIDE Properties

Melting point 122-123°C
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Soluble in DMSO (up to 20 mg/ml)
form White solid
color Lustrous crystals from Me2CO/pet ether
Water Solubility Soluble in methanol or water
Stability Store in Freezer
EPA Substance Registry System Proadifen hydrochloride (62-68-0)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312a-P330-P501a
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36-24/25
WGK Germany  3
RTECS  YV7175000
HS Code  29221990
Toxicity LD50 oral in rat: 2140mg/kg
NFPA 704
0
2 0

PROADIFEN HYDROCHLORIDE price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) P1061 Proadifen hydrochloride analytical standard, ≥95% 62-68-0 100MG ₹13087.43 2022-06-14 Buy
Sigma-Aldrich(India) P1061 Proadifen hydrochloride analytical standard, ≥95% 62-68-0 500MG ₹36826.65 2022-06-14 Buy
Sigma-Aldrich(India) 567300 SKF-525A, Hydrochloride - CAS 62-68-0 - Calbiochem Cell permeable. Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase. Also inhibits hepatic drug metabolism by inhibiti 62-68-0 1G ₹34619.99 2022-06-14 Buy
Product number Packaging Price Buy
P1061 100MG ₹13087.43 Buy
P1061 500MG ₹36826.65 Buy
567300 1G ₹34619.99 Buy

PROADIFEN HYDROCHLORIDE Chemical Properties,Uses,Production

Description

SKF 525A is a widely used, nonspecific cytochrome P (CYP)450 inhibitor that demonstrates 100% inhibition of the various CYP450 isoforms at 1-100 μM. It therefore potentiates the effects of many different drugs by inhibiting their metabolism (IC50 values in the μM range when tested using human liver microsomes). SKF 525A inhibits CYP450-dependent arachidonic acid conversion to active EET metabolites, antagonizing the recovery of functional calcium pools. It also acts as a noncompetitive inhibitor of acetylcholine nicotinic receptors (IC50 = 19 μM in mouse skeletal muscle).

Chemical Properties

Off-White Crystalline Solid

Uses

Proadifen hydrochloride is an inhibitor of NOS1, AChR, cytochrome P-450, and KIR6. Proadifen hydrochloride bind to the protein moiety of P-450, also reduced the hypoxic response. of Proadifen hydrochloride have good antiarrhythmic effects. SKF-525A substantially reduced the depletion of cardiac norepinephrine.

Safety Profile

Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and HCl.

PROADIFEN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 127)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30231 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. +86-0551-65418671 +8618949823763 China 34563 58 Inquiry
Aromsyn Co., Ltd. +86-0571-85585865 +8613336024896 China 19183 58 Inquiry
Aceschem Inc. +1-817863-6948 +1-(817)863-6948 United States 19632 58 Inquiry
Aladdin Scientific United States 57505 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131957 58 Inquiry

PROADIFEN HYDROCHLORIDE Spectrum

SKF-525A HYDROCHLORIDE >98% (PROADIFEN) ALPHA-PHENYL-ALPHA-PROPYLBENZENEACETIC ACID 2-[DIETHYLAMINO]ETHYL ESTER, HCL ALPHA-PHENYL-ALPHA-PROPYLBENZENEACETIC ACID 2-[DIETHYLAMINO]ETHYL ESTER HYDROCHLORIDE SK AND F 525A HYDROCHLORIDE SKF-525A HCL 2’-diethylaminoethyl2,2-diphenylpentanoatehydrochloride 2-diethylaminoethyl2,2-diphenylvaleratehydrochloride 2-diethylaminoethylalpha,alpha-diphenylvaleratehydrochloride 5171rp alpha-phenyl-alpha-propyl-benzeneaceticaci2-(diethylamino)ethylesterh beta-diethylaminoethyldiphenylpropylacetatehydrochloride α-phenyl-α-propylbenzeneacetic acid 2-(diethylamino)ethyl ester Proadifen, HCl, α-Phenyl-α-propylbenzeneacetic Acid 2-[Diethylamino]ethyl Ester, HCl N,N-Diethylaminoethyl 2,2-diphenylvalerate, SKF-525A, α-Phenyl-α-propylbenzeneacetic acid 2-(diethylamino)ethyl ester N,N-Diethylaminoethyl 2,2-diphenylvalerate SKF 525 U 5446 2-(diethylamino)ethyl ester ACETICACID,PROPYLDIPHENYL-,2-(DIETHYLAMINO)ETHYLESTER PROADIFEN HYDROCHLORIDE PROADIFEN, HCL Benzeneacetic acid, .alpha.-phenyl-.alpha.-propyl-, 2-(diethylamino)ethyl ester, hydrochloride Proadifen, HCl, a-Phenyl-a-propylbenzeneacetic Acid 2-[Diethylamino]ethyl Ester, HCl valericacid,2,2-diphenyl-,2-(diethylamino)ethylester,hydrochloride propyladiphenin pentanoicacid,2,2-diphenyl-,2-(n,n-diethylamino)ethylester,hydrochloride nsc39690 diethylaminoethanolesterofdiphenylpropylaceticacidhydrochloride SKF-525A, Hydrochloride - CAS 62-68-0 - Calbiochem SU-5446 SKF-525A, HYDROCHLORIDE PROADIFEN skf525a Proadifen hydrochloride (SKF-525A), Cytochrome P450 inhibitor 62-68-0 1302-33-0 C23H32ClNO2 C32H31NO2HCl C23H31NO2HCl Biochemicals and Reagents BioChemical L to O Enzymes, Inhibitors, and Substrates Enzyme Inhibitors Enzyme Inhibitors by Enzyme Nitric Oxide Synthase neuronal Inhibitors All Inhibitors Amines Aromatics CLORINE