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dendrobine

dendrobine Structure
CAS No.
2115-91-5
Chemical Name:
dendrobine
Synonyms
Dendrobine 1%;(-)-Dendrobine;12-Oxodendrobane;Dendroban-12-one;Dendrobine 2115-91-5;From Dendrobium nobile;Dendrobine Dendroban-12-one;(3α,6α,7R,8S,9R,10α,11α)-Dendrobane-12-one;(3α,6α,7R,8S,9R,10α,11α)-Dendrobane-12-one;Dendrobine, 98%, from Dendrobium nobile Lindl
CBNumber:
CB51331533
Molecular Formula:
C16H25NO2
Molecular Weight:
263.38
MOL File:
2115-91-5.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:10

dendrobine Properties

Melting point 135-136℃
Boiling point 375℃
Density 1.101
Flash point 133℃
storage temp. 4°C, protect from light
solubility ≥60mg/ml in MeOH
form Powder
pka 9.49±0.60(Predicted)
color White to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
HS Code  29399990
NFPA 704
0
2 0

dendrobine Chemical Properties,Uses,Production

Description

Dendrobine is a sesquiterpenoid that has been found in D. nobile and has anticancer activity. It decreases viability of A549 cells when used at concentrations ranging from 2.5 to 15 μg/ml. It induces apoptosis in A549 cells when used at concentrations ranging from 1 to 10 μg/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin at 10 μg/ml. Dendrobine (50 mg/kg per day) reduces tumor growth in an A549 mouse xenograft model with an additive effect when used in combination with cisplatin.

Uses

Dendrobine is an alkaloid isolated from Dendrobium nobile and is an antagonist of β-alanine, taurine and of presynaptic inhibition in the frog spinal cord.

dendrobine Preparation Products And Raw materials

Raw materials

Preparation Products

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(3α,6α,7R,8S,9R,10α,11α)-Dendrobane-12-one Dendroban-12-one 12-Oxodendrobane 7,5-(EpoxyMethano)-1H-cyclopent[cd]indol-9-one,decahydro-1,7b-diMethyl-6-(1-Methylethyl)-, (2aS,4aS,5R,6S,7R,7aS,7bR)- Dendrobine Dendroban-12-one Dendrobine 1% Dendrobine, 98%, from Dendrobium nobile Lindl Dendrobine 2115-91-5 From Dendrobium nobile (3α,6α,7R,8S,9R,10α,11α)-Dendrobane-12-one (-)-Dendrobine (2aS,2a1R,4aS,5R,8R,8aS,9S)-9-isopropyl-1,2a1-dimethyloctahydro-1H-7-oxa-1-aza-5,8-methanocyclopenta[cd]azulen-6(2a1H)-one (2aS,2a1R,4aS,5R,8R,8aS,9S)-9-Isopropyl-2a1,4-dimethyldecahydro-7H-6-oxa-4-aza-5,8-methanocyclopenta[cd]azulen-7-one 2115-91-5 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract