ChemicalBook > Product Catalog >Inorganic chemistry >Inorganic salts >Metal halide and Halogen salt >Metal chlorides and salt >CHELERYTHRINE CHLORIDE

CHELERYTHRINE CHLORIDE

CHELERYTHRINE CHLORIDE Structure
CAS No.
3895-92-9
Chemical Name:
CHELERYTHRINE CHLORIDE
Synonyms
1,2-diMethoxy-12-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-iuM chloride;TODDALIN;CHELERYTHRIN CL;Chelerythrine Cl;TODDALIN CHLORIDE;CHELERYTHRIN CHLORIDE;Chelerythrine cloride;Chelerythrine chloride;CHELERYTHRINE CHLORIDE(P);CHELERYTHRINE CHLORIDE(RG)
CBNumber:
CB3760820
Molecular Formula:
C21H18ClNO4
Molecular Weight:
383.82
MOL File:
3895-92-9.mol
MSDS File:
SDS
Modify Date:
2023/9/20 16:43:00

CHELERYTHRINE CHLORIDE Properties

Melting point 195-205 °C
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility DMSO: ≥10 mg/mL
form powder
color yellow to orange
Stability Hygroscopic
InChIKey WEEFNMFMNMASJY-UHFFFAOYSA-M

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38-36/37
Safety Statements  26-36-36/37
RIDADR  UN 1544PSN1 6.1 / PGII
WGK Germany  3
RTECS  FL9200000
HS Code  29349990
Toxicity mouse,LD50,intravenous,18500ug/kg (18.5mg/kg),Planta Medica. Vol. 43, Pg. 161, 1981.
NFPA 704
0
3 0

CHELERYTHRINE CHLORIDE price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) C2932 Chelerythrine chloride ≥95% (TLC), powder 3895-92-9 1MG ₹6267.68 2022-06-14 Buy
Sigma-Aldrich(India) C2932 Chelerythrine chloride ≥95% (TLC), powder 3895-92-9 5MG ₹20372.65 2022-06-14 Buy
Sigma-Aldrich(India) 220285 Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem Naturally-occurring alkaloid. 3895-92-9 5MG ₹15469.99 2022-06-14 Buy
ALFA India ALF-J62906-MB Chelerythrine chloride, 99+% 3895-92-9 25mg ₹60836 2022-05-26 Buy
ALFA India ALF-J62906-MA Chelerythrine chloride, 99+% 3895-92-9 10mg ₹31467 2022-05-26 Buy
Product number Packaging Price Buy
C2932 1MG ₹6267.68 Buy
C2932 5MG ₹20372.65 Buy
220285 5MG ₹15469.99 Buy
ALF-J62906-MB 25mg ₹60836 Buy
ALF-J62906-MA 10mg ₹31467 Buy

CHELERYTHRINE CHLORIDE Chemical Properties,Uses,Production

Description

Chelerythrine is a potent, cell permeable inhibitor of protein kinase C (IC50 = 660 nM) that does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase, or calcium/calmodulin-dependent protein kinase. Chelerythrine also inhibits Bcl-xL function (IC50 = 1.5 μM) by displacing Bax binding, inducing apoptosis in several cancer cell lines. Chelerythrine can also have PKC-independent effects, activate p38 MAP kinase and JUNK signaling pathways, and induce apoptosis in cancer cells both in vitro and in vivo.

Chemical Properties

yellow to orange solid

Uses

Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.

General Description

Naturally occurring alkaloid. Cell-permeable, selective inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain irrespective of the attachment of the regulatory domain. Material is a competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.

CHELERYTHRINE CHLORIDE Preparation Products And Raw materials

Global( 230)Suppliers
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CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Alfa Aesar 1 800 209 7001 Maharashtra, India 6913 58 Inquiry
Otto Chemie Pvt. Ltd. +91 9820041841 Mumbai, India 5873 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
Chengdu GLP biotechnology Co Ltd 028-87075086 13350802083 CHINA 1824 58 Inquiry
Chengdu Biopurify Phytochemicals Ltd. +8618080483897 China 3424 58 Inquiry
Xi'an Kono chem co., Ltd., 029-86107037 13289246953 China 2995 58 Inquiry
TODDALIN TODDALIN CHLORIDE 3)benzodioxolo(5,6-c)phenanthridinium,1,2-dimethoxy-12-methyl-(chloride chelerythrinehydrochloride 1,2-DIMETHOXY-12,[1,3]-BENZODIOXOLO[5,6-C]PHENANTHRIDINIUM CHLORIDE 1,2-DIMETHOXY-12-METHYL[1,3]BENZODIOXOLO[5,6-C]PHENANTHRIDINIUM CHLORIDE CHELERYTHRIN CHLORIDE CHELERYTHRIN CL Chelerythrine cloride [1,3]Benzodioxolo[5,6-c]phenanthridinium, 1,2-dimethoxy-12-methyl-, chloride (1:1) CHELERYTHRINE CHLORIDE(RG) Chelerythrine chloride,98% Chelerythrine chloride1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride Chelerythrine chloride 1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride [1,3]Benzodioxolo[5,6-c]phenanthridiniuM, 1,2-diMethoxy-12-Methyl-, chloride CHELERYTHRINE CHLORIDE(P) Chelerythrine Cl Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem 17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyclo[11.8.0.02,1.0,.01,1]henicosa-1(13),2,4(8),9,11,14,16,18,20-nonaen-21-ium chloride 1,2-diMethoxy-12-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-iuM chloride 1,2-Dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium chloride 3895-92-9 16732-75-2 C21H18ClNO4 C12H18NO4 C21H18NO4Cl BioChemical Cell Biology Cell Signaling and Neuroscience Kinase/Phosphatase Biology Protein Kinase C (PKC) Serine/Threonine Kinase Inhibitors antibiotic Herb extract Alkaloids Protein Kinase