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Dihydrochelerythrine

Dihydrochelerythrine Structure
CAS No.
6880-91-7
Chemical Name:
Dihydrochelerythrine
Synonyms
Dihydrochelerythrine;Sibutramine Impurity 8;12,13-Dihydrochelerythrine;Dihydrochelerythrine (12,13-Dihydrochelerythrine);1,2-dimethoxy-12-methyl-13H-[1,3]benzodioxolo[5,6-c]phenanthridine;1,2-dimethoxy-12-methyl-12,13-dihydro[1,3]benzodioxolo[5,6-c]phenanthridine;12,13-Dihydro-1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridine;12,13-Dihydro-1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridine;[1,3]Benzodioxolo[5,6-c]phenanthridine, 12,13-dihydro-1,2-dimethoxy-12-methyl-
CBNumber:
CB41470176
Molecular Formula:
C21H19NO4
Molecular Weight:
349.38
MOL File:
6880-91-7.mol
Modify Date:
2024/7/2 8:55:08

Dihydrochelerythrine Properties

Melting point 164-165 °C
Boiling point 565.9±50.0 °C(Predicted)
Density 1.291±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO : 50 mg/mL (143.11 mM; Need ultrasonic and warming)
form Powder
pka 2.36±0.20(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H227
Precautionary statements  P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235

Dihydrochelerythrine Chemical Properties,Uses,Production

Description

Dihydrochelerythrine is a benzophenanthridine alkaloid that has been found in Bocconia arborea and has diverse biological activities. It is active against S. aureus, S. faecalis, and C. albicans (MIC = 1.87 μg/ml for all). Dihydrochelerythrine inhibits secretion of the hepatitis B virus (HBV) antigens HBsAg and HBeAg from HepG2 2.2.15 cells (IC50s = <0.05 μM for both). It is cytotoxic to HCT8, BGC-823, and A2780 cancer cells (IC50s = 1.4, 0.4, and 3.5 μM, respectively).

Uses

Dihydrochelerythrine is synthesized as a potential G-quadrulpex DNA stabilizing agent. It is used in phamacokinetic study of chelerythrine metabolites in agro-products.

Dihydrochelerythrine Preparation Products And Raw materials

Global( 122)Suppliers
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Chengdu Greenpure Biopharma CO.,Ltd +8618283602253 China 952 58 Inquiry
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ZHEJIANG JIUZHOU CHEM CO., LTD +86-0576225566889 +86-13454675544 China 19947 58 Inquiry
Dihydrochelerythrine 12,13-Dihydro-1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridine 12,13-Dihydro-1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridine 12,13-Dihydrochelerythrine Dihydrochelerythrine (12,13-Dihydrochelerythrine) [1,3]Benzodioxolo[5,6-c]phenanthridine, 12,13-dihydro-1,2-dimethoxy-12-methyl- 1,2-dimethoxy-12-methyl-13H-[1,3]benzodioxolo[5,6-c]phenanthridine 1,2-dimethoxy-12-methyl-12,13-dihydro[1,3]benzodioxolo[5,6-c]phenanthridine Sibutramine Impurity 8 6880-91-7