5-Benzylidenehydantoin
![5-Benzylidenehydantoin Structure](CAS/GIF/3775-01-7.gif)
- CAS No.
- 3775-01-7
- Chemical Name:
- 5-Benzylidenehydantoin
- Synonyms
- RARECHEM AP KH 0029;TIMTEC-BB SBB007867;Benzylidene hydantoin;5-Benzylidendhydantoin;5-BENZYLIDENEHYDANTOIN;5-phenylmethylenehydantoin;5-Benzylideneimidazolidine-2,4-dione;5-Benzylidene-2,4-imidazolidinedione;(5E)-5-Benzylidene-2,4-imidazolidinedione;2,4-Imidazolidinedione, 5-(phenylmethylene)-
- CBNumber:
- CB5179770
- Molecular Formula:
- C10H8N2O2
- Molecular Weight:
- 188.18
- MOL File:
- 3775-01-7.mol
- Modify Date:
- 2024/7/14 20:44:35
5-Benzylidenehydantoin Chemical Properties,Uses,Production
Description
Derivatives of 5-Benzylidenehydantoin are well known of their various attractive bioactivities such as anticancer, antimicrobial, antidiabetic and tyrosinase inhibitor. UPR1024 belongs to a new class of EGFR inhibitors characterized by a hydantoin nucleus and a 5-benzylidene substituent having a double bond conjugated with a carbonyl group on the hydantoin ring. The compound had antiproliferative and proapoptotic effects when tested on the non-small cell lung cancer cell line A549[1-2].
Biological Activity
5-Benzylidenehydantoins inhibited the EGFR kinase and exhibited an antiproliferative action on A431 human epidermoid carcinoma cells. The conjugated exo-cyclic double bond at the C5 position appeared essential for both EGFR and cell growth inhibition, indicating that the 5-benzylidene hydantoin core would be a suitable scaffold for generating new antiproliferative compounds[3].
References
[1] Haq, K. U. et al. “Synthesis of 5-benzylidene-hydantoin and 5-benzylidene-creatinine derivatives under mixed catalyst systems of urea-p-toluenesulfonic acid (Urea-PTSA) and guanidine hydrochloride-triethylamine (GnHCl-TEA).”(2020).
[2] Andrea Cavazzoni. “Dual mechanisms of action of the 5-benzylidene-hydantoin UPR1024 on lung cancer cell lines.” Molecular Cancer Therapeutics 7 2 (2008): 361–70.
5-Benzylidenehydantoin Preparation Products And Raw materials
Raw materials
Preparation Products
5-Benzylidenehydantoin Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Shijiazhuang Donghua Jinlong Chemical Co., LTD | +86-031166619888 +86-19333738986 | China | 25 | 58 | Inquiry |
Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | China | 3957 | 58 | Inquiry |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9338 | 55 | Inquiry |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | China | 3878 | 58 | Inquiry |
Kindchem(Nanjing)Co.,Ltd | +86-025-025-85281586 +8618651653755 | China | 1227 | 58 | Inquiry |
Shaanxi Xihua Chemical Industry Co., Ltd | 17691182729 15529505138 | China | 9961 | 58 | Inquiry |
Shandong WorldSun Biological Technology Co., Ltd. | 0531-88723173 18596073690 | China | 4032 | 58 | Inquiry |
shanghai yayu biomedical co.,ltd | 021-54370211 18051886391 | China | 2991 | 58 | Inquiry |
Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd. | 027-83850122 13343472658 | China | 1853 | 58 | Inquiry |
Wuhan Fortuna Chemical Co., Ltd | 027-59207852 13308628970 | China | 2702 | 58 | Inquiry |
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