THIOSTREPTON
- CAS No.
- 1393-48-2
- Chemical Name:
- THIOSTREPTON
- Synonyms
- x146;a-8506;thiactin;bryamycin;hiostrepton;THIOSTREPTON;Thiostreptin;THIOSTREPTION;antibioticx146;(-)-Nuciferine
- CBNumber:
- CB5204768
- Molecular Formula:
- C72H85N19O18S5
- Molecular Weight:
- 1664.89
- MOL File:
- 1393-48-2.mol
- Modify Date:
- 2023/8/30 13:35:17
| Melting point | 248-257°C (dec.) |
|---|---|
| alpha | D23 -98.5° (glacial acetic acid); -61° (dioxane); -20° (pyridine) |
| Density | 1.0824 (rough estimate) |
| refractive index | 1.6700 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble in DMSO or chloroform |
| form | Off-white powder |
| pka | 10.43±0.46(Predicted) |
| color | Off-white |
| Water Solubility | 0.24g/L(28 ºC) |
| Merck | 13,9440 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P271-P261-P280 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XN6300100 | |||||||||
| F | 10-21 | |||||||||
| HS Code | 29419090 | |||||||||
| Toxicity | LD50 oral in mouse: > 1gm/kg | |||||||||
| NFPA 704 |
|
THIOSTREPTON price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 598226 | Thiostrepton - CAS 1393-48-2 - Calbiochem Thiostrepton, CAS 1393-48-2, is an antibiotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit. | 1393-48-2 | 1G | ₹10670 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 598226 | Thiostrepton - CAS 1393-48-2 - Calbiochem Thiostrepton, CAS 1393-48-2, is an antibiotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit. | 1393-48-2 | 1G | ₹10670 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T8902 | Thiostrepton from Streptomyces azureus ≥90% (HPLC) | 1393-48-2 | 1G | ₹18250.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 598226 | Thiostrepton - CAS 1393-48-2 - Calbiochem Thiostrepton, CAS 1393-48-2, is an antibiotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit. | 1393-48-2 | 10G | ₹81340.01 | 2022-06-14 | Buy |
THIOSTREPTON Chemical Properties,Uses,Production
Description
The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Thiostrepton is a natural peptide thiazole antibiotic that inhibits FoxM1 in mammalian cells, preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself. Through this mechanism, thiostrepton prevents proliferation and induces apoptosis in human cancer cells. These effects correlate with the ability of thiostrepton to act as a proteasome inhibitor.
Chemical Properties
Off-White Solid
Uses
Thiostrepton is a macrocyclic antibiotic incorporating thiazoles and other atypical amino acids. Patented in 1961, thiostrepton has been used as an antibiotic and acts by binding to ribosomes to prevent the binding of the EF-G elongation factor and GTP to the 50S ribosomal subunit. Thiostrepton is an inducer of tipA, a gene that controls the bacterial transcription regulators, TipAL and TipAS, that are central regulators in multidrug resistance. Thiostrepton is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.
Definition
ChEBI: A heterodetic cyclic peptide, in which the cyclisation step involves a formal lactonisation between the carboxy group of a quinaldic acid-based residue and a secondary alcohol. An antibiotic that inhibits bacterial protein synthesis. Also acts as an antitu or agent.
General Description
A thiazole-containing peptide antibiotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit. Inhibits the function of elongation factor G (EF-G) and the dissociation of EF-G from the ribosome. The thiostrepton-resistant gene is also commonly used as a selective marker for recombinant DNA/plasmid technologies.
THIOSTREPTON Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12460 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | China | 8828 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
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