THIOSTREPTON
THIOSTREPTON
- CAS:
- 1393-48-2
- MF:
- C72H85N19O18S5
- MW:
- 1664.89
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Properties
- Melting point:
- 248-257°C (dec.)
- alpha
- D23 -98.5° (glacial acetic acid); -61° (dioxane); -20° (pyridine)
- Density
- 1.0824 (rough estimate)
- refractive index
- 1.6700 (estimate)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO or chloroform
- form
- Off-white powder
- pka
- 10.43±0.46(Predicted)
- color
- Off-white
- Water Solubility
- 0.24g/L(28 ºC)
- Merck
- 13,9440
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302+H312+H332
- Precautionary statements
- P271-P261-P280
- Hazard Codes
- Xn
- Risk Statements
- 22
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- RTECS
- XN6300100
- F
- 10-21
- HS Code
- 29419090
- Toxicity
- LD50 oral in mouse: > 1gm/kg
Use
Thiostrepton is a macrocyclic antibiotic incorporating thiazoles and other atypical amino acids. Patented in 1961, thiostrepton has been used as an antibiotic and acts by binding to ribosomes to prevent the binding of the EF-G elongation factor and GTP to the 50S ribosomal subunit. Thiostrepton is an inducer of tipA, a gene that controls the bacterial transcription regulators, and TipAL and TipAS, that are central regulators in multidrug resistance. Thiostrepton is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.
1 India supplier list of "THIOSTREPTON"
- Product Name:Thiostrepton-CAS1393-48-2-Calbiochem
- Products Intro:Brand:sigma aldrich | Product Number:598226 | Purity:Thiostrepton,CAS1393-48-2,isanantibioticthatinhibitsproteinsynthesisbypreventing
- Company Type: Trader
- Country/Region: INDIA
- Product Name:THIOSTREPTON
- Products Intro:Purity: 99% | Package: 25KG
- Company Type: Service provider
- Country/Region: CHINA
$0.00/ 25KG
- Product Name:THIOSTREPTON
- Products Intro:Purity: 99% | Package: 1PCS;1USD
- Company Type: Trader
- Country/Region: CHINA
$1.00/ 1PCS