THIQ

CAS No.: 312637-48-2

Chemical Name:: THIQ

Synonyms: THIQ;THIQ, 10 mM in DMSO;(3R)-N-[(1R)-1-[(4-Chlorophenyl)methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidiny;mutant,MC Receptor,inhibit,THIQ,melanocortin,affinity,activity,erectile,selective,eliciting,Melanocortin Receptor,Inhibitor;N-[(1R)-1-[(4-Chlorophenyl)methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-trazol-1-ylmethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide;(R)-N-((R)-1-(4-((1H-1,2,4-Triazol-1-yl)methyl)-4-cyclohexylpiperidin-1-yl)-3-(4-chlorophenyl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide;(3R)-N-[(2R)-3-(4-chlorophenyl)-1-{4-cyclohexyl-4-[(1H-1,2,4-triazol-1-yl)methyl]piperidin-1-yl}-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide;(3R)-N-[(1R)-1-[(4-Chlorophenyl)Methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylMethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxaMide;3-IsoquinolinecarboxaMide, N-[(1R)-1-[(4-chlorophenyl)Methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylMethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-, (3R)-

CBNumber:: CB52459564

Molecular Formula:: C33H41ClN6O2

Molecular Weight:: 589.17

MOL File:: 312637-48-2.mol

Modify Date:: 2025/4/17 18:22:24

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THIQ Properties

Density	1.33±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 250 mg/mL (424.33 mM; Need ultrasonic)
form	Powder
pka	13.82±0.20(Predicted)
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

THIQ Chemical Properties,Uses,Production

Uses

Melanocortin 4 receptors play important roles in the regulation of energy homeostasis, eating behavior and sexual functions (1). (3R)-N-[(1R)-1-[(4-Chlorophenyl)methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide is a potent and selective melanocortin 4 receptor agonist (2,3). It inhibits parasympathetic preganglionic neurons in the brainstem and regulates sympathetic and parasympathetic preganglionic neurons.

Biological Activity

Potent and selective melanocortin 4 (MC 4 ) receptor agonist (IC 50 values are 1.2, 761 and 2067 nM for human MC 4 , MC 3 and MC 1 receptors respectively). Enhances intracavernosal pressure and stimulates erectile activity in rats ex copula following systemic administration.

THIQ Preparation Products And Raw materials

Raw materials

Preparation Products

THIQ Suppliers

Global( 56)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	32159	58	Inquiry
TargetMol Chemicals Inc.		United States	38630	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8467	58	Inquiry
Aladdin Scientific		United States	52924	58	Inquiry
Henan Alpha Chemical Co., Ltd.	0371-55013243 15324716602	China	10003	58	Inquiry
TargetMol Chemicals Inc.	4008200310	China	24642	58	Inquiry
Shanghai Jieshikai Biotechnology Co. , Ltd.	021-57520305 15801958784	China	49234	58	Inquiry
https://hanhongsci.com/	021-54306202 18917919676	China	29998	58	Inquiry
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	China	5237	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
Henan Alpha Chemical Co., Ltd.	58
TargetMol Chemicals Inc.	58
Shanghai Jieshikai Biotechnology Co. , Ltd.	58
https://hanhongsci.com/	58
Nantong QuanYi Biotechnology Co., Ltd	58

312637-48-2(THIQ)Related Search:

4-CYCLOHEXYLPIPERIDINE HYDROCHLORIDE 1,2,3,4-Tetrahydroisoquinoline-3-carboxamide 4-(1,2,4-TRIAZOLE-1-YL)-BUTYLAMINE 2-Methylamino-1-morpholin-4-yl-ethanone hydrochloride (R)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID AMIDE

THIQ

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3-IsoquinolinecarboxaMide, N-[(1R)-1-[(4-chlorophenyl)Methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylMethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-, (3R)- (3R)-N-[(1R)-1-[(4-Chlorophenyl)Methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylMethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxaMide THIQ N-[(1R)-1-[(4-Chlorophenyl)methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-trazol-1-ylmethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (R)-N-((R)-1-(4-((1H-1,2,4-Triazol-1-yl)methyl)-4-cyclohexylpiperidin-1-yl)-3-(4-chlorophenyl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (3R)-N-[(1R)-1-[(4-Chlorophenyl)methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidiny mutant,MC Receptor,inhibit,THIQ,melanocortin,affinity,activity,erectile,selective,eliciting,Melanocortin Receptor,Inhibitor (3R)-N-[(2R)-3-(4-chlorophenyl)-1-{4-cyclohexyl-4-[(1H-1,2,4-triazol-1-yl)methyl]piperidin-1-yl}-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide THIQ, 10 mM in DMSO 312637-48-2 C33H41ClN6O2