3-[4-(2-Methoxyethyl)phenoxy]-

3-[4-(2-Methoxyethyl)phenoxy]- Structure
CAS No.
62572-90-1
Chemical Name:
3-[4-(2-Methoxyethyl)phenoxy]-
Synonyms
Metoprolol-4;Metoprolol Diol;Metoprolol EP Impurity 4;Desloratadine EP Impurity;3-[4-(2-Methoxyethyl)phenoxy]-;Metoprolol tartrate impurity D;Metoprolol Impurity-D(70% pure);Metoprolol Succinate Impurity D;Metoprolol EP Tartrate IMpurity-D;Metoprolol tartrate EP impurity D
CBNumber:
CB52510735
Molecular Formula:
C12H18O4
Molecular Weight:
226.27
MOL File:
62572-90-1.mol
MSDS File:
SDS
Modify Date:
2023/4/23 13:52:06

3-[4-(2-Methoxyethyl)phenoxy]- Properties

Boiling point 382.7±32.0 °C(Predicted)
Density 1.145±0.06 g/cm3(Predicted)
storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form Solid
pka 13.53±0.20(Predicted)
color White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335-H303
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501

3-[4-(2-Methoxyethyl)phenoxy]- Chemical Properties,Uses,Production

Chemical Properties

White Low Melting Solid

Uses

3-[4-(2-Methoxyethyl)phenoxy]-1,2-propanediol (Metoprolol EP Impurity D) is a new byproduct detected in Metoprolol tartrate. Metoprolol (M338790) impurity.

Synthesis Reference(s)

Synthetic Communications, 20, p. 3489, 1990 DOI: 10.1080/00397919008051592

3-[4-(2-Methoxyethyl)phenoxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[4-(2-Methoxyethyl)phenoxy]- 3-[4-(2-Methoxyethyl)phenoxy]-1,2-propanediol Metoprolol EP Tartrate IMpurity-D Metoprolol Impurity-D(70% pure) Metoprolol tartrate impurity D Metoprolol tartrate EP impurity D Desloratadine EP Impurity 1,2-Propanediol, 3-[4-(2-methoxyethyl)phenoxy]- (2RS)-3-[4-(2-Methoxyethyl)phenoxy] Imp. D (EP):(2RS)-3-[4-(2-Methoxyethyl)phenoxy]propane-1,2-diol Metoprolol Impurity 4(Metoprolol EP Impurity D) (2RS)-3-[4-(2-Methoxyethyl)phenoxy]propane-1,2-diol Metoprolol impurity 3/Metoprolol EP Impurity D/3-[4-(2-Methoxyethyl)phenoxy]-1,2-propanediol Metoprolol-4 Metoprolol Succinate EP Impurity D Metoprolol Succinate Impurity D Metoprolol Diol Metoprolol EP Impurity 4 Metoprolol EP Impurity D (2RS)-3-[4-(2-Methoxyethyl)phenoxy]propane-1,2-diol 62572-90-1 C12H13D5O4 Impurities Isotope Labelled Compounds Metabolites & Impurities Aromatics